Analytical and finite element modelling of long plate mode jumping behaviour

Trapezoidal sheeting of thin-walled steel is applied frequently for roofing and cladding. As such, it is loaded by a concentrated load (at the support) and a bending moment. A recently developed model to predict the sheeting's failure behaviour leaves the question open whether mode jumping (the phenomenon that a plate dynamically changes its buckling mode during an increasing load) should be taken into account in the model. This article presents the analytical and finite element modelling of square and long plates, which, depending on the boundary conditions, may represent the compressed flange of trapezoidal sheeting. The analytical modelling is based on the combination of several displacement functions and using the principle of minimal potential energy. Hereafter the stability of each part of the resulting equilibrium curves is determined. A spin-off of the analytical model is an analytical expression for a current curve-fitted based prediction formula for the post/pre buckling stiffness ratio by Rhodes. Furthermore, the accuracy range of a solution by Williams and Walker for the far-post buckling behaviour can be confirmed. The finite element modelling has been carried out by implicit dynamic, and explicit (dynamic) simulations. Both for the load levels and the buckling mode sequences, the analytical and finite element models give equivalent results. It is concluded that for the specific boundary conditions that represent the situation of a compressed flange for trapezoidal sheeting, it is very likely that mode jumping will not occur

Analytical and finite element modelling of long plate mode jumping behaviour

Trapezoidal sheeting of thin-walled steel is applied frequently for roofing and cladding. As such, it is loaded by a concentrated load (at the support) and a bending moment. A recently developed model to predict the sheeting's failure behaviour leaves the question open whether mode jumping (the phenomenon that a plate dynamically changes its buckling mode during an increasing load) should be taken into account in the model. This article presents the analytical and finite element modelling of square and long plates, which, depending on the boundary conditions, may represent the compressed flange of trapezoidal sheeting. The analytical modelling is based on the combination of several displacement functions and using the principle of minimal potential energy. Hereafter the stability of each part of the resulting equilibrium curves is determined. A spin-off of the analytical model is an analytical expression for a current curve-fitted based prediction formula for the post/pre buckling stiffness ratio by Rhodes. Furthermore, the accuracy range of a solution by Williams and Walker for the far-post buckling behaviour can be confirmed. The finite element modelling has been carried out by implicit dynamic, and explicit (dynamic) simulations. Both for the load levels and the buckling mode sequences, the analytical and finite element models give equivalent results. It is concluded that for the specific boundary conditions that represent the situation of a compressed flange for trapezoidal sheeting, it is very likely that mode jumping will not occur

Fire safe buildings with thin-walled steel + insulation systems

BackgroundIt is important that buildings should be able to withstand a fire during evacuation and extinguishment. To determine a building’s fire resistance ability, full scale experiments would be ideal, but these are very expensive. Therefore an existing simulation approach will be extended, whichenables theoretical models and design rules to be developed to predict system failure as a function of component failure

Experimental Research on the Behaviour of Combined Web Crippling and Bending of Steel Deck Sections

At an interior support, sections of cold-formed steel are subjected to a concentrated load and a bending moment Existing design rules describing the section failure at an interior support are subject to improvement and are not based on the section\u27s physical failure behaviour. In the last decade, several analytical models have been developed that predict the section ultimate concentrated load and directly include the influence of the bending moment, so that an empirical interaction method is not needed. However, the authors believe that these models are correct only for a concentrated load and a small bending moment In practice large bending moments occur. Therefore, the aim of the current research project is to develop an analytical model for trapezoidal hat sections subjected to a concentrated load and a bending moment as occurring in practice. The development of this model will be based on both experimental and numerical research will be carried out. In this article, a part of the experimental research will be presented

Experimental Research on the Behaviour of Combined Web Crippling and Bending of Steel Deck Sections

At an interior support, sections of cold-formed steel are subjected to a concentrated load and a bending moment Existing design rules describing the section failure at an interior support are subject to improvement and are not based on the section\u27s physical failure behaviour. In the last decade, several analytical models have been developed that predict the section ultimate concentrated load and directly include the influence of the bending moment, so that an empirical interaction method is not needed. However, the authors believe that these models are correct only for a concentrated load and a small bending moment In practice large bending moments occur. Therefore, the aim of the current research project is to develop an analytical model for trapezoidal hat sections subjected to a concentrated load and a bending moment as occurring in practice. The development of this model will be based on both experimental and numerical research will be carried out. In this article, a part of the experimental research will be presented

Toolbox for super-structured and super-structure free multi-disciplinary building spatial design optimisation

Multi-disciplinary optimisation of building spatial designs is characterised by large solution spaces. Here two approaches are introduced, one being super-structured and the other super-structure free. Both are different in nature and perform differently for large solution spaces and each requires its own representation of a building spatial design, which are also presented here. A method to combine the two approaches is proposed, because the two are prospected to supplement each other. Accordingly a toolbox is presented, which can evaluate the structural and thermal performances of a building spatial design to provide a user with the means to define optimisation procedures. A demonstration of the toolbox is given where the toolbox has been used for an elementary implementation of a simulation of co-evolutionary design processes. The optimisation approaches and the toolbox that are presented in this paper will be used in future efforts for research into- and development of optimisation methods for multi-disciplinary building spatial design optimisation

Statistical evaluation of a new resistance model for cold-formed stainless steel cross-sections subjected to web crippling

This paper presents a statistical evaluation according to Annex D of EN 1990 (2002) of a new resistance function for web crippling design of cold-formed stainless steel cross-sections. This resistance function was derived by Bock et al. (2013) through the use of carefully validated numerical models with the aim to propose a design expression for stainless steel sections, which are currently designed following the provisions for cold-formed carbon steel sections given in EN 1993-1-3 (2006). Although it was shown that the proposed design equation is appropriate for application to various stainless steels, the statistical uncertainties in material properties that the different types of stainless steels exhibit require an assessment of various partial safety factors. The statistical assessment showed that the proposed resistance function by Bock et al. (2013) requires adjustment to satisfy the safety level set out in EN 1993-1-4 (2006); A recalibration is performed herein. The web crippling design provisions given in EN 1993-1-3 (2006) and SEI/ASCE 8-02 (2002) American standard for application to stainless steel are also statistically evaluated herein. Comparison with test and numerical data showed that the predictions of the recalibrated resistance function are better suited and consistent than existing design provisionsResearch Fund for Coal and Stee

bantam Is Required for Optic Lobe Development and Glial Cell Proliferation

microRNAs (miRNAs) are small, conserved, non-coding RNAs that contribute to the control of many different cellular processes, including cell fate specification and growth control. Drosophila bantam, a conserved miRNA, is involved in several functions, such as stimulating proliferation and inhibiting apoptosis in the wing disc. Here, we reported the detailed expression pattern of bantam in the developing optic lobe, and demonstrated a new, essential role in promoting proliferation of mitotic cells in the optic lobe, including stem cells and differentiated glial cells. Changes in bantam levels autonomously affected glial cell number and distribution, and non-autonomously affected photoreceptor neuron axon projection patterns. Furthermore, we showed that bantam promotes the proliferation of mitotically active glial cells and affects their distribution, largely through down regulation of the T-box transcription factor, optomotor-blind (omb, Flybase, bifid). Expression of omb can rescue the bantam phenotype, and restore the normal glial cell number and proper glial cell positioning in most Drosophila brains. These results suggest that bantam is critical for maintaining the stem cell pools in the outer proliferation center and glial precursor cell regions of the optic lobe, and that its expression in glial cells is crucial for their proliferation and distribution

A protocol for a systematic review of knowledge translation strategies in the allied health professions

<p>Abstract</p> <p>Background</p> <p>Knowledge translation (KT) aims to close the gap between knowledge and practice in order to realize the benefits of research through (a) improved health outcomes, (b) more effective health services and products, and (c) strengthened healthcare systems. While there is some understanding of strategies to put research findings into practice within nursing and medicine, we have limited knowledge of KT strategies in allied health professions. Given the interprofessional nature of healthcare, a lack of guidance for supporting KT strategies in the allied health professions is concerning. Our objective in this study is to systematically review published research on KT strategies in five allied health disciplines.</p> <p>Methods</p> <p>A medical research librarian will develop and implement search strategies designed to identify evidence that is relevant to each question of the review. Two reviewers will perform study selection and quality assessment using standard forms. For study selection, data will be extracted by two reviewers. For quality assessment, data will be extracted by one reviewer and verified by a second. Disagreements will be resolved through discussion or third party adjudication. Within each profession, data will be grouped and analyzed by research design and KT strategies using the Effective Practice and Organisation of Care Review Group classification scheme. An overall synthesis across professions will be conducted.</p> <p>Significance</p> <p>A uniprofessional approach to KT does not represent the interprofessional context it targets. Our findings will provide the first systematic overview of KT strategies used in allied health professionals' clinical practice, as well as a foundation to inform future KT interventions in allied healthcare settings.</p

Study protocol: a double blind placebo controlled trial examining the effect of domperidone on the composition of breast milk [NCT00308334]

BACKGROUND: Domperidone, a drug that enhances upper gastric motility, is an anti-dopaminergic medication that also elevates prolactin levels. It has been shown to safely increase the milk supply of lactating women. To date, researchers have analyzed the effects of domperidone on lactating woman with respect to the quantity of their milk production, adverse effects, and drug levels in the breast milk. However, the effect of domperidone on the macronutrient composition of breast milk has not been studied and current guidelines for fortification of human milk for premature infants do not distinguish between those women using or those not using domperidone. The purpose of this study is to evaluate the effect of domperidone (given to lactating mothers of very preterm infants) on the macronutrient composition of breast milk. METHODS/DESIGN: Mothers of infants delivered at less than 31 weeks gestation, who are at least 3 weeks postpartum, and experiencing lactational failure despite non-pharmacological interventions, will be randomized to receive domperidone (10 mg three times daily) or placebo for a 14-day period. Breast milk samples will be obtained the day prior to beginning treatment and on days 4, 7 and 14. The macronutrient (protein, fat, carbohydrate and energy) and macromineral content (calcium, phosphorus and sodium) will be analyzed and compared between the two groups. Additional outcome measures will include milk volumes, serum prolactin levels (measured on days 0, 4, and 10), daily infant weights and breastfeeding rates at 2 weeks post study completion and at discharge. Forty-four participants will be recruited into the study. Analysis will be carried out using the intention to treat approach. DISCUSSION: If domperidone causes significant changes to the nutrient content of breast milk, an alteration in feeding practices for preterm infants may need to be made in order to optimize growth, nutrition and neurodevelopment outcomes