Desempenho do Concreto Compactado com Rolo com adição de cinza de madeira moída

TCC (graduação) - Universidade Federal de Santa Catarina. Campus Joinville. Engenharia de Infraestrutura.O modal rodoviário corresponde a maior parcela do transporte brasileiro, porém 57% dos pavimentos apresenta algum tipo de deficiência. Dado este cenário, faz-se necessário o desenvolvimento de novos materiais e processos que melhorem a situação. Aliado a isso, a elevada quantidade de resíduos industriais que geram impactos negativos no meio ambiente, tem resultado em estudos de novos materiais para aplicações na construção civil que busquem a sustentabilidade no aproveitamento dos mesmos. Considerando este contexto, o uso de adições minerais em pavimentos apresenta grande potencial. Assim, o presente trabalho teve como objetivo a análise do comportamento do Concreto Compactado com Rolo com substituição do agregado miúdo pela adição de cinza de madeira moída nas proporções de 0% (referência), 7,5% e 15%. Para tal, primeiramente foi realizada a caracterização dos agregados e do resíduo através dos ensaios de massa específica, granulometria e absorção de água. Definida a dosagem, realizou-se a produção do CCR e, após 28 dias, os ensaios de resistência à compressão e algumas propriedades físicas. Os resultados obtidos indicaram aumento na resistência à compressão do CCR, apontando viabilidade técnica do uso do resíduo no CCR

Encoding NF-κB temporal control in response to TNF: distinct roles for the negative regulators IκBα and A20

TNF-induced NF-κB activity shows complex temporal regulation whose different phases lead to distinct gene expression programs. Combining experimental studies and mathematical modeling, we identify two temporal amplification steps—one determined by the obligate negative feedback regulator IκBα—that define the duration of the first phase of NF-κB activity. The second phase is defined by A20, whose inducible expression provides for a rheostat function by which other inflammatory stimuli can regulate TNF responses. Our results delineate the nonredundant functions implied by the knockout phenotypes of iκbα and a20, and identify the latter as a signaling cross-talk mediator controlling inflammatory and developmental responses

Fibrinogen Excretion in the Urine and Immunoreactivity in the Kidney Serves as a Translational Biomarker for Acute Kidney Injury

Fibrinogen (Fg) is significantly up-regulated in the kidney after acute kidney injury (AKI). We evaluated the performance of Fg as a biomarker for early detection of AKI. In rats and mice with kidney tubular damage induced by ischemia/reperfusion (I/R) or cisplatin administration, respectively; kidney tissue and urinary Fg increased significantly and correlated with histopathological injury, urinary kidney injury molecule-1 (KIM-1) and N-acetyl glucosaminidase (NAG) corresponding to the progression and regression of injury temporally. In a longitudinal follow-up of 31 patients who underwent surgical repair of abdominal aortic aneurysm, urinary Fg increased earlier than SCr in patients who developed postoperative AKI (AUC-ROC = 0.72). Furthermore, in a cohort of patients with biopsy-proven AKI (n = 53), Fg immunoreactivity in the tubules and interstitium increased remarkably and was able to distinguish patients with AKI from those without AKI (n = 59). These results suggest that immunoreactivity of Fg in the kidney, as well as urinary excretion of Fg, serves as a sensitive and early diagnostic translational biomarker for detection of AKI

Factors influencing the success and complications of intraosseous access in pediatric patients—a prospective nationwide surveillance study in Germany

BackgroundVascular access is essential for the efficient treatment of critically ill children, but it can be difficult to obtain. Our study was conducted to analyze the feasibility and short-term safety of intraosseous access (IO) use as well as factors influencing its success and the incidence of complications in pediatric emergencies and resuscitation. This dataset of systematically documented intraosseous access attempts constitutes one of the largest published in the literature.MethodsTwo-year nationwide prospective surveillance study in Germany from July 2017 to June 2019. Pediatric hospitals anonymously reported the case data of all children aged 28 days to 18 years who arrived with or were treated with an intraosseous access to the German Pediatric Surveillance Unit (GPSU). The main outcomes were the occurrence of complications, overall success and success at the first attempt. The influence of individual factors on outcomes was evaluated using multivariate regression models.ResultsA total of 417 patients underwent 549 intraosseous access attempts. The overall rates of success and success at the first attempt were 98.3% and 81.9%, respectively. Approximately 63.6% of patients were successfully punctured within 3 min from the time of indication. Approximately 47.7% of IO access attempts required patient resuscitation. Dislocation [OR 17.74 (5.32, 59.15)] and other complications [OR 9.29 (2.65, 32.55)] occurred more frequently in the prehospital environment. A total of 22.7% of patients experienced minor complications, while 2.5% of patients experienced potentially severe complications.ConclusionWe conclude that intraosseous access is a commonly used method for establishing emergency vascular access in children, being associated with a low (age-dependent) rate of severe complications and providing mostly reliable vascular access despite a relatively high rate of dislocation

Miradas y perspectivas : El presente del regionalismo latinoamericano y europeo

En la presente edición se convocó a los participantes de la Segunda Escuela Doctoral de Regionalismo Latinoamericano, Europeo y Comparado, que fuera organizada por el Centro Andino de Estudios Internacionales (CAEI) de la Universidad Andina Simón Bolívar, conjuntamente con el Centro de Estudios sobre la Integración Regional Comparada de la Universidad de las Naciones Unidas, UNU-CRIS. A la organización de esta actividad se sumaron otras instituciones en calidad de colaboradoras como GIGA Hamburgo, Universidad de Barcelona, Universidad de Puerto Rico, Universidad de los Andes, Latin, BID, Fundación Getulio Vargas (Río de Janeiro), FES y FLACSO. Dicha propuesta tuvo lugar en el mes de julio de 2013 en la ciudad de Quito, Ecuador, ocasión en la que asistieron 23 alumnos provenientes de cuatro continentes: América, Europa, Asia y África, de los cuales diez eran becarios de la UASB. (Párrafo extraído del texto a modo de resumen)Instituto de Relaciones Internacionale

Demokratie und Partizipation in der Begegnung mit Kinderliteratur an der Freien Universität Bozen

Literatur bietet sich wie kaum ein anderes Medium an, bereits im (früh-)pädagogischen Kontext des Kindergartens und der Grundschule mit Kindern demokratische Formen des Miteinanders nicht nur zum Gesprächsthema zu machen, sondern in der Gesprächsgestaltung auch partizipativ umzusetzen. Für die Eröffnung literarischer Partizipationsspielräume braucht es in der Professionalisierung von Kindheitspädagog:innen und Lehrer:innen literarische Orte wie etwa Hochschullernwerkstätten an der Universität, ausgestattet mit vielfältigen Medien (multimodal, mehrsprachig, intermedial) für vielfältige Rezeptionsformen. Dieser Beitrag gibt einen exemplarischen Einblick in einen solchen Ort, die KinderLiteraturWerkstatt an der Freien Universität Bozen, und eine Auswahl an literarästhetisch anregender, aktueller Kinderliteratur zum Thema Demokratie und Partizipation aus verschiedenen sprachlich-kulturellen Kontexten. (DIPF/Orig.

Selenium and Selenoprotein Deficiencies Induce Widespread Pyogranuloma Formation in Mice, while High Levels of Dietary Selenium Decrease Liver Tumor Size Driven by TGFα

Changes in dietary selenium and selenoprotein status may influence both anti- and pro-cancer pathways, making the outcome of interventions different from one study to another. To characterize such outcomes in a defined setting, we undertook a controlled hepatocarcinogenesis study involving varying levels of dietary selenium and altered selenoprotein status using mice carrying a mutant (A37G) selenocysteine tRNA transgene ($Trsp^{tG37}$) and/or a cancer driver TGFα transgene. The use of $Trsp^{tG37}$ altered selenoprotein expression in a selenoprotein and tissue specific manner and, at sufficient dietary selenium levels, separate the effect of diet and selenoprotein status. Mice were maintained on diets deficient in selenium (0.02 ppm selenium) or supplemented with 0.1, 0.4 or 2.25 ppm selenium or 30 ppm triphenylselenonium chloride (TPSC), a non-metabolized selenium compound. $Trsp^{tG37}$ transgenic and TGFα/$Trsp^{tG37}$ bi-transgenic mice subjected to selenium-deficient or TPSC diets developed a neurological phenotype associated with early morbidity and mortality prior to hepatocarcinoma development. Pathology analyses revealed widespread disseminated pyogranulomatous inflammation. Pyogranulomas occurred in liver, lungs, heart, spleen, small and large intestine, and mesenteric lymph nodes in these transgenic and bi-transgenic mice. The incidence of liver tumors was significantly increased in mice carrying the TGFα transgene, while dietary selenium and selenoprotein status did not affect tumor number and multiplicity. However, adenoma and carcinoma size and area were smaller in TGFα transgenic mice that were fed 0.4 and 2.25 versus 0.1 ppm of selenium. Thus, selenium and selenoprotein deficiencies led to widespread pyogranuloma formation, while high selenium levels inhibited the size of TGFα–induced liver tumors

Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells

The thymic function to produce self-protective and self-tolerant T cells is chiefly mediated by cortical thymic epithelial cells (cTECs) and medullary TECs (mTECs). Recent studies including single-cell transcriptomic analyses have highlighted a rich diversity in functional mTEC subpopulations. Because of their limited cellularity, however, the biochemical characterization of TECs, including the proteomic profiling of cTECs and mTECs, has remained unestablished. Utilizing genetically modified mice that carry enlarged but functional thymuses, here we show a combination of proteomic and transcriptomic profiles for cTECs and mTECs, which identified signature molecules that characterize a developmental and functional contrast between cTECs and mTECs. Our results reveal a highly specific impact of the thymoproteasome on proteasome subunit composition in cTECs and provide an integrated trans-omics platform for further exploration of thymus biology