Vergleich verschiedener Verhaltenstherapieformen bei aggressiven Hunden

Ziel der Studie war es, drei verschiedene Verhaltenstherapieformen bei aggressiven Hunden auf ihren Behandlungserfolg hin zu vergleichen

An Architecture for Peer-to-Peer Integration of Interorganizational Information Systems

On the business case of independent sales agencies we discuss the requirements of tiny sized enterprises for data integration. If a multitude of independent enterprises need to be integrated, we argue that those are best represented by equal peers and describe the Architecture of VIANA: a Peer-to-Peer architecture for materialized integration of information systems, both in the interas well as the intraorganizational domain. VIANA propagates updates on data between peers and continuously monitors data quality. We argue that this type of integration can be accomplished with ideally no alteration of the participating information systems and that the integration may benefit substantially from existing data exchange formats. To this end we formulate the architecture in a way that existing XML technologies and standards may be utilized without the need for alterations

Tangle analysis of difference topology experiments: applications to a Mu protein-DNA complex

We develop topological methods for analyzing difference topology experiments involving 3-string tangles. Difference topology is a novel technique used to unveil the structure of stable protein-DNA complexes involving two or more DNA segments. We analyze such experiments for the Mu protein-DNA complex. We characterize the solutions to the corresponding tangle equations by certain knotted graphs. By investigating planarity conditions on these graphs we show that there is a unique biologically relevant solution. That is, we show there is a unique rational tangle solution, which is also the unique solution with small crossing number.Comment: 60 pages, 74 figure

With or Without Blockchain? Towards a Decentralized, SSI-based eRoaming Architecture

Fragmentation and limited accessibility of charging infrastructure impede the adoption of electric vehicles. To improve the availability of charging infrastructure independent of providers, eRoaming offers a promising solution. Yet, current eRoaming systems are typically centralized, which raises concerns of market power concentration. While the use of blockchain technology can obviate such concerns, it comes with significant privacy challenges. To address these challenges, we explore a combination of blockchain with self-sovereign identity. Specifically, we apply a design science research approach, which helps us to identify requirements, derive a conceptual architecture, and deduce design principles for decentralized eRoaming and beyond. We find that blockchain may best leverage its benefits when it takes a backseat as a public registry for legal entities. Moreover, we find that the use of self-sovereign identities could improve compliance with privacy regulations, but they should not be overused

MINFLUX nanoscopy delivers 3D multicolor nanometer resolution in cells.

The ultimate goal of biological super-resolution fluorescence microscopy is to provide three-dimensional resolution at the size scale of a fluorescent marker. Here we show that by localizing individual switchable fluorophores with a probing donut-shaped excitation beam, MINFLUX nanoscopy can provide resolutions in the range of 1 to 3 nm for structures in fixed and living cells. This progress has been facilitated by approaching each fluorophore iteratively with the probing-donut minimum, making the resolution essentially uniform and isotropic over scalable fields of view. MINFLUX imaging of nuclear pore complexes of a mammalian cell shows that this true nanometer-scale resolution is obtained in three dimensions and in two color channels. Relying on fewer detected photons than standard camera-based localization, MINFLUX nanoscopy is poised to open a new chapter in the imaging of protein complexes and distributions in fixed and living cells