KCNQ channels regulate age-related memory impairment:KCNQ regulates age-related memory

In humans KCNQ2/3 heteromeric channels form an M-current that acts as a brake on neuronal excitability, with mutations causing a form of epilepsy. The M-current has been shown to be a key regulator of neuronal plasticity underlying associative memory and ethanol response in mammals. Previous work has shown that many of the molecules and plasticity mechanisms underlying changes in alcohol behaviour and addiction are shared with those of memory. We show that the single KCNQ channel in Drosophila (dKCNQ) when mutated show decrements in associative short- and long-term memory, with KCNQ function in the mushroom body α/βneurons being required for short-term memory. Ethanol disrupts memory in wildtype flies, but not in a KCNQ null mutant background suggesting KCNQ maybe a direct target of ethanol, the blockade of which interferes with the plasticity machinery required for memory formation. We show that as in humans, Drosophila display age-related memory impairment with the KCNQ mutant memory defect mimicking the effect of age on memory. Expression of KCNQ normally decreases in aging brains and KCNQ overexpression in the mushroom body neurons of KCNQ mutants restores age-related memory impairment. Therefore KCNQ is a central plasticity molecule that regulates age dependent memory impairment

The 1982 ASEE-NASA Faculty Fellowship program (Aeronautics and Research)

The NASA/ASEE Summer Faculty Fellowship Program (Aeronautics and Research) conducted at the NASA Goddard Space Flight Center during the summer of 1982 is described. Abstracts of the Final Reports submitted by the Fellows detailing the results of their research are also presented

The 1984 ASEE-NASA summer faculty fellowship program (aeronautics and research)

The 1984 NASA-ASEE Faculty Fellowship Program (SFFP) is reported. The report includes: (1) a list of participants; (2) abstracts of research projects; (3) seminar schedule; (4) evaluation questionnaire; and (5) agenda of visitation by faculty programs committee. Topics discussed include: effects of multiple scattering on laser beam propagation; information management; computer techniques; guidelines for writing user documentation; 30 graphics software; high energy electron and antiproton cosmic rays; high resolution Fourier transform infrared spectrum; average monthly annual zonal and global albedos; laser backscattering from ocean surface; image processing systems; geomorphological mapping; low redshift quasars; application of artificial intelligence to command management systems

Star-Formation in Low Radio Luminosity AGN from the Sloan Digital Sky Survey

We investigate faint radio emission from low- to high-luminosity Active Galactic Nuclei (AGN) selected from the Sloan Digital Sky Survey (SDSS). Their radio properties are inferred by co-adding large ensembles of radio image cut-outs from the FIRST survey, as almost all of the sources are individually undetected. We correlate the median radio flux densities against a range of other sample properties, including median values for redshift, [OIII] luminosity, emission line ratios, and the strength of the 4000A break. We detect a strong trend for sources that are actively undergoing star-formation to have excess radio emission beyond the ~10^28 ergs/s/Hz level found for sources without any discernible star-formation. Furthermore, this additional radio emission correlates well with the strength of the 4000A break in the optical spectrum, and may be used to assess the age of the star-forming component. We examine two subsamples, one containing the systems with emission line ratios most like star-forming systems, and one with the sources that have characteristic AGN ratios. This division also separates the mechanism responsible for the radio emission (star-formation vs. AGN). For both cases we find a strong, almost identical, correlation between [OIII] and radio luminosity, with the AGN sample extending toward lower, and the star-formation sample toward higher luminosities. A clearer separation between the two subsamples is seen as function of the central velocity dispersion of the host galaxy. For systems with similar redshifts and velocity dispersions, the star-formation subsample is brighter than the AGN in the radio by an order of magnitude. This underlines the notion that the radio emission in star-forming systems can dominate the emission associated with the AGN.Comment: Accepted for publication in Astronomical Journal; 15 pages, 8 color figure

HI Density Distribution Driven by Supernovae: A Simulation Study

We model the complex distribution of atomic hydrogen (HI) in the interstellar medium (ISM) assuming that it is driven entirely by supernovae (SN). We develop and assess two different models. In the first approach, the simulated volume is randomly populated with non-overlapping voids of a range of sizes. This may relate to a snapshot distribution of supernova-remnant voids, although somewhat artificially constrained by the non-overlap criterion. In the second approach, a simplified time evolution (considering momentum conservation as the only governing constraint during interactions) is followed as SN populate the space with the associated input mass and energy. We describe these simulations and present our results in the form of images of the mass and velocity distributions and the associated power spectra. The latter are compared with trends indicated by available observations. In both approaches, we find remarkable correspondence with the observed statistical description of well-studied components of the ISM, wherein the spatial spectra have been found to show significant deviations from the Kolmogorov spectrum. One of the key indications from this study, regardless of whether or not the SN-induced turbulence is the dominant process in the ISM, is that the apparent non-Kolmogorov spectral characteristics (of HI and/or electron column density across thick or thin screens) needed to explain related observations may not at all be in conflict with the underlying turbulence (i.e. the velocity structure) being of Kolmogorov nature. We briefly discuss the limitations of our simulations and the various implications of our results.Comment: To appear in Astrophysical Journal. 21 pages, 6 figure

NASA rotor system research aircraft flight-test data report: Helicopter and compound configuration

The flight test activities of the Rotor System Research Aircraft (RSRA), NASA 740, from June 30, 1981 to August 5, 1982 are reported. Tests were conducted in both the helicopter and compound configurations. Compound tests reconfirmed the Sikorsky flight envelope except that main rotor blade bending loads reached endurance at a speed about 10 knots lower than previously. Wing incidence changes were made from 0 to 10 deg

The kiloparsec-scale star formation law at redshift 4: wide-spread, highly efficient star formation in the dust-obscured starburst galaxy GN20

We present high-resolution observations of the 880 $\mu$m (rest-frame FIR) continuum emission in the z$=$4.05 submillimeter galaxy GN20 from the IRAM Plateau de Bure Interferometer (PdBI). These data resolve the obscured star formation in this unlensed galaxy on scales of 0.3$^{\prime\prime}$$\times$0.2$^{\prime\prime}$ ($\sim$2.1$\times$1.3 kpc). The observations reveal a bright (16$\pm$1 mJy) dusty starburst centered on the cold molecular gas reservoir and showing a bar-like extension along the major axis. The striking anti-correlation with the HST/WFC3 imaging suggests that the copious dust surrounding the starburst heavily obscures the rest-frame UV/optical emission. A comparison with 1.2 mm PdBI continuum data reveals no evidence for variations in the dust properties across the source within the uncertainties, consistent with extended star formation, and the peak star formation rate surface density (119$\pm$8 M$_{\odot}$ yr$^{-1}$ kpc$^{-2}$) implies that the star formation in GN20 remains sub-Eddington on scales down to 3 kpc$^2$. We find that the star formation efficiency is highest in the central regions of GN20, leading to a resolved star formation law with a power law slope of $\Sigma_{\rm SFR}$ $\sim$ $\Sigma_{\rm H_2}^{\rm 2.1\pm1.0}$, and that GN20 lies above the sequence of normal star-forming disks, implying that the dispersion in the star formation law is not due solely to morphology or choice of conversion factor. These data extend previous evidence for a fixed star formation efficiency per free-fall time to include the star-forming medium on $\sim$kpc-scales in a galaxy 12 Gyr ago.Comment: 6 pages, 5 figures, accepted to ApJ

Intermediate progenitors support migration of neural stem cells into dentate gyrus outer neurogenic niches.

The hippocampal dentate gyrus (DG) is a unique brain region maintaining neural stem cells (NCSs) and neurogenesis into adulthood. We used multiphoton imaging to visualize genetically defined progenitor subpopulations in live slices across key stages of mouse DG development, testing decades old static models of DG formation with molecular identification, genetic-lineage tracing, and mutant analyses. We found novel progenitor migrations, timings, dynamic cell-cell interactions, signaling activities, and routes underlie mosaic DG formation. Intermediate progenitors (IPs, Tbr2+) pioneered migrations, supporting and guiding later emigrating NSCs (Sox9+) through multiple transient zones prior to converging at the nascent outer adult niche in a dynamic settling process, generating all prenatal and postnatal granule neurons in defined spatiotemporal order. IPs (Dll1+) extensively targeted contacts to mitotic NSCs (Notch active), revealing a substrate for cell-cell contact support during migrations, a developmental feature maintained in adults. Mouse DG formation shares conserved features of human neocortical expansion

HST Studies of the WLM Galaxy. I. The Age and Metallicity of the Globular Cluster

We have obtained V and I images of the lone globular cluster that belongs to the dwarf Local Group irregular galaxy known as WLM. The color-magnitude diagram of the cluster shows that it is a normal old globular cluster with a well-defined giant branch reaching to M_V=-2.5, a horizontal branch at M_V=+0.5, and a sub-giant branch extending to our photometry limit of M_V=+2.0. A best fit to theoretical isochrones indicates that this cluster has a metallicity of [Fe/H]=-1.52\pm0.08 and an age of 14.8\pm0.6 Gyr, thus indicating that it is similar to normal old halo globulars in our Galaxy. From the fit we also find that the distance modulus of the cluster is 24.73\pm0.07 and the extinction is A_V=0.07\pm0.06, both values that agree within the errors with data obtained for the galaxy itself by others. We conclude that this normal massive cluster was able to form during the formation of WLM, despite the parent galaxy's very small intrinsic mass and size.Comment: 14 pages, 5 figures, 1 tabl