Timed-Automata-Based Verification of MITL over Signals

It has been argued that the most suitable semantic model for real-time formalisms is the non-negative real line (signals), i.e. the continuous semantics, which naturally captures the continuous evolution of system states. Existing tools like UPPAAL are, however, based on omega-sequences with timestamps (timed words), i.e. the pointwise semantics. Furthermore, the support for logic formalisms is very limited in these tools. In this article, we amend these issues by a compositional translation from Metric Temporal Interval Logic (MITL) to signal automata. Combined with an emptiness-preserving encoding of signal automata into timed automata, we obtain a practical automata-based approach to MITL model-checking over signals. We implement the translation in our tool MightyL and report on case studies using LTSmin as the back-end

Caffeic acid phenethyl amide ameliorates ischemia/reperfusion injury and cardiac dysfunction in streptozotocin-induced diabetic rats

BACKGROUND: Caffeic acid phenethyl ester (CAPE) has been shown to protect the heart against ischemia/reperfusion (I/R) injury by various mechanisms including its antioxidant effect. In this study, we evaluated the protective effects of a CAPE analog with more structural stability in plasma, caffeic acid phenethyl amide (CAPA), on I/R injury in streptozotocin (STZ)-induced type 1 diabetic rats. METHODS: Type 1 diabetes mellitus was induced in Sprague–Dawley rats by a single intravenous injection of 60 mg/kg STZ. To produce the I/R injury, the left anterior descending coronary artery was occluded for 45 minutes, followed by 2 hours of reperfusion. CAPA was pretreated intraperitoneally 30 minutes before reperfusion. An analog devoid of the antioxidant property of CAPA, dimethoxyl CAPA (dmCAPA), and a nitric oxide synthase (NOS) inhibitor (Nω-nitro-l-arginine methyl ester [l-NAME]) were used to evaluate the mechanism involved in the reduction of the infarct size following CAPA-treatment. Finally, the cardioprotective effect of chronic treatment of CAPA was analyzed in diabetic rats. RESULTS: Compared to the control group, CAPA administration (3 and 15 mg/kg) significantly reduced the myocardial infarct size after I/R, while dmCAPA (15 mg/kg) had no cardioprotective effect. Interestingly, pretreatment with a NOS inhibitor, (l-NAME, 3 mg/kg) eliminated the effect of CAPA on myocardial infarction. Additionally, a 4-week CAPA treatment (1 mg/kg, orally, once daily) started 4 weeks after STZ-induction could effectively decrease the infarct size and ameliorate the cardiac dysfunction by pressure-volume loop analysis in STZ-induced diabetic animals. CONCLUSIONS: CAPA, which is structurally similar to CAPE, exerts cardioprotective activity in I/R injury through its antioxidant property and by preserving nitric oxide levels. On the other hand, chronic CAPA treatment could also ameliorate cardiac dysfunction in diabetic animals

Association between the neutrophil-to-lymphocyte ratio and cognitive impairment: a meta-analysis of observational studies

BackgroundSystemic inflammation is one of the underlying mechanisms of cognitive impairment. The neutrophil-to-lymphocyte ratio (NLR) has emerged as a systemic inflammation indicator. This meta-analysis aimed to evaluate the association between high NLR and cognitive impairment (CI) risk.MethodA comprehensive systematic search was conducted to identify eligible studies published until May 30, 2023. The reference group comprised patients with the lowest NLR level, whereas the exposure group comprised those with the highest NLR level. The main outcome was to examine the relationship between NLR and CI risk. The secondary outcome included the association between patient characteristics or comorbidities and CI risk.ResultsThis meta-analysis included 11 studies published between 2018 and 2023, involving 10,357 patients. Patients with CI had a higher NLR than those without (mean difference=0.35, 95% confidence interval [CI]: 0.26–0.44, p < 00001, I2 = 86%). Consistently, pooled results revealed an association between high NLR and CI risk (odds ratio [OR]=2.53, 95% CI:1.67–3.82, p<0.0001, I2 = 84%). Furthermore, aging (mean difference =4.31 years, 95% CI:2.83–5.8, p < 0.00001, I2 = 92%), diabetes (OR=1.59, 95% CI:1.35–1.88, p < 0.00001, I2 = 66%), and hypertension (OR=1.36, 95% CI:1.19–1.57, p < 0.00001, I2 = 0%) were significant risk factors for CI. However, no significant associations were observed between CI and male gender (OR = 0.84, 95% CI:0.64–1.11, p = 0.22, I2 = 81%), body mass index (mean = −0.32 kg/m2, 95% CI: −0.82, 0.18, p = 0.2, I2 = 82%), alcohol consumption (OR = 1.11, 95% CI:0.95−1.3, p = 1.35, I2 = 0%), and smoking (OR = 0.99, 95% CI:0.87–1.13, p = 0.86, I2 = 0%). Meta-regression found that diabetes and hypertension, but not age, significantly moderated the association between NLR and CI.ConclusionThis meta-analysis showed a significant association between high NLR and increased CI risk. Moreover, meta-regression identified diabetes and hypertension, but not age, as significant moderating factors in the relationship between NLR and CI. To validate and strengthen these findings, further large-scale studies are required.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023430384, identifier CRD42023430384

JINGLE, a JCMT legacy survey of dust and gas for galaxy evolution studies - I. Survey overview and first results

JINGLE is a new JCMT legacy survey designed to systematically study the cold interstellar medium of galaxies in the local Universe. As part of the survey we perform 850 μm continuum measurements with SCUBA-2 for a representative sample of 193 Herschel-selected galaxies with M* \u3e 109 M⊙, as well as integrated CO(2-1) line fluxes with RxA3m for a subset of 90 of these galaxies. The sample is selected from fields covered by the Herschel-ATLAS survey that are also targeted by the MaNGA optical integral-field spectroscopic survey. The new JCMT observations combined with the multiwavelength ancillary data will allow for the robust characterization of the properties of dust in the nearby Universe, and the benchmarking of scaling relations between dust, gas, and global galaxy properties. In this paper we give an overview of the survey objectives and details about the sample selection and JCMT observations, present a consistent 30-band UV-to-FIR photometric catalogue with derived properties, and introduce the JINGLE Main Data Release. Science highlights include the non-linearity of the relation between 850 μm luminosity and CO line luminosity (log LCO(2-1) = 1.372 logL850-1.376), and the serendipitous discovery of candidate z \u3e 6 galaxies

JINGLE, a JCMT legacy survey of dust and gas for galaxy evolution studies: II. SCUBA-2 850 μm data reduction and dust flux density catalogues

We present the SCUBA-2 850μm component of JINGLE, the new JCMT large survey for dust and gas in nearby galaxies, which with 193 galaxies is the largest targeted survey of nearby galaxies at 850 μm. We provide details of our SCUBA-2 data reduction pipeline, optimized for slightly extended sources, and including a calibration model adjusted to match conventions used in other far-infrared (FIR) data. We measure total integrated fluxes for the entire JINGLE sample in 10 infrared/submillimetre bands, including all WISE, Herschel-PACS, Herschel-SPIRE, and SCUBA-2 850 μm maps, statistically accounting for the contamination by CO(J = 3-2) in the 850 μm band. Of our initial sample of 193 galaxies, 191 are detected at 250 μm with a ≥5σ significance. In the SCUBA-2 850 μm band we detect 126 galaxies with ≥3σ significance. The distribution of the JINGLE galaxies in FIR/sub-millimetre colour-colour plots reveals that the sample is not well fit by single modified-blackbody models that assume a single dust-emissivity index (β). Instead, our new 850 μm data suggest either that a large fraction of our objects require β < 1.5, or that a model allowing for an excess of sub-mm emission (e.g. a broken dust emissivity law, or a very cold dust component ≲10 K) is required. We provide relations to convert FIR colours to dust temperature and β for JINGLE-like galaxies. For JINGLE the FIR colours correlate more strongly with star-formation rate surface-density rather than the stellar surface-density, suggesting heating of dust is greater due to younger rather than older stellar-populations, consistent with the low proportion of early-type galaxies in the sample

Women with endometriosis have higher comorbidities: Analysis of domestic data in Taiwan

AbstractEndometriosis, defined by the presence of viable extrauterine endometrial glands and stroma, can grow or bleed cyclically, and possesses characteristics including a destructive, invasive, and metastatic nature. Since endometriosis may result in pelvic inflammation, adhesion, chronic pain, and infertility, and can progress to biologically malignant tumors, it is a long-term major health issue in women of reproductive age. In this review, we analyze the Taiwan domestic research addressing associations between endometriosis and other diseases. Concerning malignant tumors, we identified four studies on the links between endometriosis and ovarian cancer, one on breast cancer, two on endometrial cancer, one on colorectal cancer, and one on other malignancies, as well as one on associations between endometriosis and irritable bowel syndrome, one on links with migraine headache, three on links with pelvic inflammatory diseases, four on links with infertility, four on links with obesity, four on links with chronic liver disease, four on links with rheumatoid arthritis, four on links with chronic renal disease, five on links with diabetes mellitus, and five on links with cardiovascular diseases (hypertension, hyperlipidemia, etc.). The data available to date support that women with endometriosis might be at risk of some chronic illnesses and certain malignancies, although we consider the evidence for some comorbidities to be of low quality, for example, the association between colon cancer and adenomyosis/endometriosis. We still believe that the risk of comorbidity might be higher in women with endometriosis than that we supposed before. More research is needed to determine whether women with endometriosis are really at risk of these comorbidities

Topics in monitoring and planning for embedded real-time systems

The verification of real-time systems has gained much interest in the formal verification community during the past two decades. In this thesis, we investigate two real-time verification problems that benefit from the techniques normally used in untimed verification. The first part of this thesis is concerned with the monitoring of real-time specifications. We study the expressiveness of metric temporal logics over timed words, a problem that dates back to early 1990s. We show that the logic obtained by extending Metric Temporal Logic (MTL) with two families of new modalities is expressively complete for the Monadic First-Order Logic of Order and Metric (FO[&lt;,+1]) in time-bounded settings. Furthermore, by allowing rational constants, expressive completeness also holds in the general (time-unbounded) setting. Finally, we incorporate several notions and techniques from LTL monitoring to obtain the first trace-length independent monitoring procedure for this logic. The second part of this thesis concerns a decision problem regarding UAVs: given a set of targets (each ascribed with a relative deadline) and flight times between each pair of targets, is there a way to coordinate a flock of k identical UAVs so that all targets are visited infinitely often and no target is ever left unvisited for a time longer than its relative deadline? We show that the problem is PSPACE-complete even in the single-UAV case, thereby corrects an erroneous claim from the literature. We then complement this result by proposing an efficient antichain-based approach where a delayed simulation is used to prune the state space. Experimental results clearly demonstrate the effectiveness of our approach.</p

Topics in monitoring and planning for embedded real-time systems

The verification of real-time systems has gained much interest in the formal verification community during the past two decades. In this thesis, we investigate two real-time verification problems that benefit from the techniques normally used in untimed verification. The first part of this thesis is concerned with the monitoring of real-time specifications. We study the expressiveness of metric temporal logics over timed words, a problem that dates back to early 1990s. We show that the logic obtained by extending Metric Temporal Logic (MTL) with two families of new modalities is expressively complete for the Monadic First-Order Logic of Order and Metric (FO[&lt;,+1]) in time-bounded settings. Furthermore, by allowing rational constants, expressive completeness also holds in the general (time-unbounded) setting. Finally, we incorporate several notions and techniques from LTL monitoring to obtain the first trace-length independent monitoring procedure for this logic. The second part of this thesis concerns a decision problem regarding UAVs: given a set of targets (each ascribed with a relative deadline) and flight times between each pair of targets, is there a way to coordinate a flock of k identical UAVs so that all targets are visited infinitely often and no target is ever left unvisited for a time longer than its relative deadline? We show that the problem is PSPACE-complete even in the single-UAV case, thereby corrects an erroneous claim from the literature. We then complement this result by proposing an efficient antichain-based approach where a delayed simulation is used to prune the state space. Experimental results clearly demonstrate the effectiveness of our approach.This thesis is not currently available in OR

Estado actual y consideraciones sobre la veterinaria

Abstract. Consider a finite set of targets, with each target assigned a relative deadline, and each pair of targets assigned a fixed transit flight time. Given a flock of identical UAVs, can one ensure that every target is repeatedly visited by some UAV at intervals of duration at most the target&apos;s relative deadline? The uav Problem is the question of whether this task has a solution. This problem can straightforwardly be solved in PSPACE by modelling it as a network of timed automata. The special case of there being a single UAV is claimed to be NP-complete in the literature. In this paper, we show that the uav Problem is in fact PSPACE-complete even in the single-UAV case.