『eラーニング支援室』の設置について

1 はじめに 2 eラーニング支援室概要 2.1 施設概要 2.2 支援業務概要 3 支援の例 4 おわり

Premedication with midazolam in intellectually disabled dental patients: intramuscular or oral administration? A retrospective study

Background: The use of midazolam for dental care in patients with intellectual disability is poorly documented. The purpose of this study was to determine which method of premedication is more effective for these patients, 0.15 mg/kg of intramuscular midazolam or 0.3 mg/kg of oral midazolam. Material and Methods: This study was designed and implemented as a non-randomized retrospective study. The study population was composed of patients with intellectual disability who required dental treatment under ambulatory general anesthesia from August 2009 through April 2013. Patients were administered 0.15 mg/kg of midazolam intramuscularly (Group IM) or 0.3 mg/kg orally (Group PO). The predictor variable was the method of midazolam administration. The outcome variables measured were Observer’s Assessment of Alertness/ Sedation (OAA/S) Scale scores, the level of cooperation when entering the operation room and for venous cannulation, post-anesthetic agitation and recovery time. Results: Midazolam was administered intramuscularly in 23 patients and orally in 21 patients. More patients were successfully sedated with no resistance behavior during venous cannulation in Group PO than in Group IM ( p =0.034). There were no differences in demographic data and other variables between the groups. Conclusions: The results of this study suggest that oral premedication with 0.3 mg/kg of midazolam is more effective than 0.15 mg/kg of midazolam administered intramuscularly, in terms of patient resistance to venous cannulation. If both oral and intramuscular routes of midazolam are acceptable in intellectually disabled patients, the oral route is recommended

Measured Dissipated-Energy in Switching-off by Electric Contacts

The measurement of the dissipated energy in switching-off has been attempted to make clear the function of spark on electric contacts, which may unfortunately cause the combustible gas, such as propane gas etc, to catch fire and result in fire accidents. By utilizing the "Memoriscope" has been the meaurement carried out and the feature of this method is to provide the information on not only the amount of dissipated energy involved in one action but also on the trace of its instantaneous power which can affect catching fire delicately. Presented in this paper are the discussion of this measuring method and the measured results which are obtained experimentally in order to investigate the dependence of the energy dissipation on variety of contacts, contacts' deterioration and circuit arrangements

Probing Symmetry-Breaking Pattern Using Sfermion Masses

We study the mass spectrum of superparticles within supersymmetric grand unified models. For gaugino masses, it is pointed out that the GUT-relation in the $SU(5)$ model is applicable to a more general case where a grand-unified gauge group breaks down to the standard model gauge group by several steps. We also show that the mass spectrum of squarks and sleptons carries the information on the breaking pattern of the gauge symmetry. It is demonstrated in some $SO(10)$ models how the scalar mass spectrum distinguishes various $SO(10)$ breaking patterns from each other.Comment: LaTeX file, 11 pages, 5 PostScript figures, appended in uuencoded format. Tohoku University preprint TU-439, June 1993, final version accepted for publication in Phys. Lett.

Improvement of the Efficacy of 5-aminolevulinic Acid-mediated Photodynamic Treatment in Human Oral Squamous Cell Carcinoma HSC-4

Ever since protoporphyrin IX (PpIX) was discovered to accumulate preferentially in cancer cells after 5-aminolevulinic acid (ALA) treatment, photodynamic treatment or therapy (PDT) has been developed as an exciting new treatment option for cancer patients. However, the level of PpIX accumulation in oral cancer is fairly low and insufficient for PDT. Ferrochelatase (FECH) and ATP-binding cassette transporter G2 (ABCG2) are known to regulate PpIX accumulation. In addition, serum enhances PpIX export by ABCG2. We investigated here whether and how inhibitors of FECH and ABCG2 and their combination could improve PpIX accumulation and PDT efficacy in an oral cancer cell line in serum-containing medium. ABCG2 inhibitor and the combination of ABCG2 and FECH inhibitors increased PpIX in the presence of fetal bovine serum (FBS) in an oral cancer cell line. Analysis of ABCG2 gene silencing also revealed the involvement of ABCG2 in the regulation of PpIX accumulation. Inhibitors of FECH and ABCG2, and their combination increased the efficiency of ALA-PDT even in the presence of FBS. ALA-PDT-induced cell death was accompanied by apoptotic events and lipid peroxidation. These results suggest that accumulation of PpIX is determined by the activities of ABCG2 and FECH and that treatment with a combination of their inhibitors improves the efficacy of PDT for oral cancer, especially in the presence of serum

A Kerato-Epithelin (βig-h3) Mutation in Lattice Corneal Dystrophy Type IIIA

This report covers phase 2 of the IWMI-Tata Water Policy Research Program (ITP) for the period 2006-2010. The major areas of action: Research focusing on water sector issues concerning underprivileged communities and backward regions in the country; Idea-incubation for livelihoods enhancement efforts using water as a central input, supporting the Trust in their water sector partnerships; Dissemination and raising public awareness; Widening the network of research partners; Policy influencing

Structural and photophysical characterisation of coordination and optical isomers of mononuclear ruthenium(II) polypyridyl 1,2,4-triazole complexes

The X-ray crystal structure of the N2 isomers of the Ru(bipy)2 complexes of Hphpztr (1) and Hpztr (2), (bipy = 2,2'-bipyridine, Hphpztr = 2-(5'-phenyl-4'H-[1,2,4]triazol-3'-yl)pyrazine and Hpztr = 2-(4'H-[1,2,4]triazol-3'-yl)pyrazine) are reported. The molecular structure obtained for 2 demonstrates an interesting structural aspect in the sharing of a single proton between two molecular units. The isolation of the Δ and Λ stereoisomers of 1 and [Ru(phen)2(pztr)]+ (phen = 1,10-phenanthroline) (3) by semipreparative HPLC is also reported. The compounds obtained are characterised by electronic spectroscopy and particular attention is paid to the photophysical properties of Δ and Λ isomers of 1 and 3, in chiral enantiopure and racemic solvents