The Prognostic Effect of Ethnicity for Gastric and Esophageal Cancer: The Population-Based Experience in British Columbia, Canada

Background: Gastric and esophageal cancers are among the most lethal human malignancies. Their epidemiologyis geographically diverse. This study compares the survival of gastric and esophageal cancer patients amongseveral ethnic groups including Chinese, South Asians, Iranians and Others in British Columbia (BC), Canada.Methods: Data were obtained from the population-based BC Cancer Registry for patients diagnosed with invasiveesophageal and gastric cancer between 1984 and 2006. The ethnicity of patients was estimated according to theirnames and categorized as Chinese, South Asian, Iranian or Other. Cox proportional hazards regression analysis wasused to estimate the effect of ethnicity adjusted for patient sex and age, disease histology, tumor location, diseasestage and treatment.Results: The survival of gastric cancer patients was significantly different among ethnic groups. Chinese patientsshowed better survival compared to others in univariate and multivariate analysis. The survival of esophagealcancer patients was significantly different among ethnic groups when the data was analyzed by a univariate test(p = 0.029), but not in the Cox multivariate model adjusted for other patient and prognostic factors.Conclusions: Ethnicity may represent underlying genetic factors. Such factors could influence host-tumorinteractions by altering the tumor’s etiology and therefore its chance of spreading. Alternatively, genetic factorsmay determine response to treatments. Finally, ethnicity may represent non-genetic factors that affect survival.Differences in survival by ethnicity support the importance of ethnicity as a prognostic factor, and may provideclues for the future identification of genetic or lifestyle factors that underlie these observations

Convergence of resonances on thin branched quantum wave guides

We prove an abstract criterion stating resolvent convergence in the case of operators acting in different Hilbert spaces. This result is then applied to the case of Laplacians on a family X_\eps of branched quantum waveguides. Combining it with an exterior complex scaling we show, in particular, that the resonances on X_\eps approximate those of the Laplacian with ``free'' boundary conditions on $X_0$, the skeleton graph of X_\eps.Comment: 48 pages, 1 figur

Spectral Analysis for Matrix Hamiltonian Operators

In this work, we study the spectral properties of matrix Hamiltonians generated by linearizing the nonlinear Schr\"odinger equation about soliton solutions. By a numerically assisted proof, we show that there are no embedded eigenvalues for the three dimensional cubic equation. Though we focus on a proof of the 3d cubic problem, this work presents a new algorithm for verifying certain spectral properties needed to study soliton stability. Source code for verification of our comptuations, and for further experimentation, are available at http://www.math.toronto.edu/simpson/files/spec_prop_code.tgz.Comment: 57 pages, 22 figures, typos fixe

Shapes of leading tunnelling trajectories for single-electron molecular ionization

Based on the geometrical approach to tunnelling by P.D. Hislop and I.M. Sigal [Memoir. AMS 78, No. 399 (1989)], we introduce the concept of a leading tunnelling trajectory. It is then proven that leading tunnelling trajectories for single-active-electron models of molecular tunnelling ionization (i.e., theories where a molecular potential is modelled by a single-electron multi-centre potential) are linear in the case of short range interactions and "almost" linear in the case of long range interactions. The results are presented on both the formal and physically intuitive levels. Physical implications of the obtained results are discussed.Comment: 14 pages, 5 figure

Resonances Width in Crossed Electric and Magnetic Fields

We study the spectral properties of a charged particle confined to a two-dimensional plane and submitted to homogeneous magnetic and electric fields and an impurity potential. We use the method of complex translations to prove that the life-times of resonances induced by the presence of electric field are at least Gaussian long as the electric field tends to zero.Comment: 3 figure

Diamonds's Temperature: Unruh effect for bounded trajectories and thermal time hypothesis

We study the Unruh effect for an observer with a finite lifetime, using the thermal time hypothesis. The thermal time hypothesis maintains that: (i) time is the physical quantity determined by the flow defined by a state over an observable algebra, and (ii) when this flow is proportional to a geometric flow in spacetime, temperature is the ratio between flow parameter and proper time. An eternal accelerated Unruh observer has access to the local algebra associated to a Rindler wedge. The flow defined by the Minkowski vacuum of a field theory over this algebra is proportional to a flow in spacetime and the associated temperature is the Unruh temperature. An observer with a finite lifetime has access to the local observable algebra associated to a finite spacetime region called a "diamond". The flow defined by the Minkowski vacuum of a (four dimensional, conformally invariant) quantum field theory over this algebra is also proportional to a flow in spacetime. The associated temperature generalizes the Unruh temperature to finite lifetime observers. Furthermore, this temperature does not vanish even in the limit in which the acceleration is zero. The temperature associated to an inertial observer with lifetime T, which we denote as "diamond's temperature", is 2hbar/(pi k_b T).This temperature is related to the fact that a finite lifetime observer does not have access to all the degrees of freedom of the quantum field theory.Comment: One reference correcte

Evaluation of effective resistances in pseudo-distance-regular resistor networks

In Refs.[1] and [2], calculation of effective resistances on distance-regular networks was investigated, where in the first paper, the calculation was based on the stratification of the network and Stieltjes function associated with the network, whereas in the latter one a recursive formula for effective resistances was given based on the Christoffel-Darboux identity. In this paper, evaluation of effective resistances on more general networks called pseudo-distance-regular networks [21] or QD type networks \cite{obata} is investigated, where we use the stratification of these networks and show that the effective resistances between a given node such as $\alpha$ and all of the nodes $\beta$ belonging to the same stratum with respect to $\alpha$ ($R_{\alpha\beta^{(m)}}$, $\beta$ belonging to the $m$-th stratum with respect to the $\alpha$) are the same. Then, based on the spectral techniques, an analytical formula for effective resistances $R_{\alpha\beta^{(m)}}$ such that $L^{-1}_{\alpha\alpha}=L^{-1}_{\beta\beta}$ (those nodes $\alpha$, $\beta$ of the network such that the network is symmetric with respect to them) is given in terms of the first and second orthogonal polynomials associated with the network, where $L^{-1}$ is the pseudo-inverse of the Laplacian of the network. From the fact that in distance-regular networks, $L^{-1}_{\alpha\alpha}=L^{-1}_{\beta\beta}$ is satisfied for all nodes $\alpha,\beta$ of the network, the effective resistances $R_{\alpha\beta^{(m)}}$ for $m=1,2,...,d$ ($d$ is diameter of the network which is the same as the number of strata) are calculated directly, by using the given formula.Comment: 30 pages, 7 figure