772 research outputs found
Changes in Dielectric Properties and the Mechanism of Water Adsorption of wood by Heat Treatment(ABSTRACTS (PH D FOR GRADUATE SCHOOL OF AGRICULTURE))
Basic Research on an Application of Geometric Programming to Sequential Unconstrained Minimization Technique
The disintegrin echistatin in combination with doxorubicin targets high-metastatic human osteosarcoma overexpressing Ī±Ī½Ī²3 integrin in chick embryo and nude mouse models.
Echistatin, a cyclic RGD peptide, which is an antagonist of Ī±vĪ²3 integrin (disintegrin), inhibited human osteosarcoma in the chick chorioallontoic membrane (CAM) model and tumor growth and pulmonary metastases in a nude mouse orthotopic model. A high-metastatic variant of human osteosarcoma, 143B-LM4, overexpressing Ī±vĪ²3 integrin was used. Tumor angiogenesis by high-metastatic variant 143B-LM4 cells in the CAM was significantly inhibited by echistatin (P<0.05) as was overall growth. A doxorubicin (DOX)-echistatin combination inhibited orthotopic tumor growth compared to untreated control (P<0.01) or DOX alone (P<0.05) in nude mice. Tumor-bearing mice treated with the DOX-echistatin combination survived longer than those treated with DOX alone or control PBS (P<0.01 and P<0.01, respectively). Echistatin also inhibited experimental lung metastasis of 143B-LM4 cells in nude mice. These results suggest that DOX in combination with a disintegrin has potential to treat osteosarcoma and that Ī±vĪ²3 integrin may be a target for osteosarcoma
Effect of Silicon Crystallite Size on Its Electrochemical Performance for Lithium-Ion Batteries
It is reported that silicon (Si) anodes with a smaller crystallite size show better electrochemical performance in lithium-ion batteries (LIBs); Si particles with different diameters are also used. However, it is yet to be clarified whether the better performance is attributed to crystallite size or particle diameter. The effect of Si crystallite size on its anode performance using Si particles having the same diameter and different crystallite sizes is investigated. Longer cycle life is obtained for smaller crystallite size, due to the small amount of the amorphous Li-rich LiāSi phase formed during charging. The phase is likely to form in a greater amount in Si particles with larger crystallite size, leading to degradation of the Si electrode at an early stage. Furthermore, Si electrodes with larger crystallite size show superior rate performance because of the high Li diffusion rate into the broader grain boundary; on the other hand, Si with smaller crystallite size should limit Li diffusion due to the narrower grain boundary. Therefore, smaller crystallite size helps improve the cycle life but deteriorates the rate performance of LIBs
Disintegrin targeting of an Ī±vĪ²3 integrin-over-expressing high-metastatic human osteosarcoma with echistatin inhibits cell proliferation, migration, invasion and adhesion in vitro.
The in vitro efficacy of the disintegrin echistatin was tested on a high-metastatic variant of 143B human osteosarcoma, 143B-LM4, which over-expresses Ī±vĪ²3 integrin. Echistatin is an RGD cyclic peptide and an antagonist of Ī±vĪ²3 integrin. In the present study, echistatin inhibited cell proliferation, migration, invasion, and adhesion of 143B-LM4 cells. 143B-LM4 cell proliferation decreased after treatment with echistatin in a time-dependent and dose-dependent manner (P <0.01). In vitro migration and invasion of 143B-LM4 cells were also inhibited by echistatin in a dose-dependent manner (P <0.01, respectively). Cell adhesion to vitronectin of 143B-LM4 cells was also inhibited by echistatin in a dose-dependent manner (P <0.01). These results suggest that Ī±vĪ²3 integrin may be an effective target for osteosarcoma
Development of an accurate kinetic model for the central carbon metabolism of Escherichia coli
Additional file 2. Comparison of our kinetic model with other existing models
Epitaxially stabilized iridium spinel oxide without cations in the tetrahedral site
Single-crystalline thin film of an iridium dioxide polymorph Ir2O4 has been
fabricated by the pulsed laser deposition of LixIr2O4 precursor and the
subsequent Li-deintercalation using soft chemistry. Ir2O4 crystallizes in a
spinel (AB2O4) without A cations in the tetrahedral site, which is
isostructural to lambda-MnO2. Ir ions form a pyrochlore sublattice, which is
known to give rise to a strong geometrical frustration. This Ir spinel was
found to be a narrow gap insulator, in remarkable contrast to the metallic
ground state of rutile-type IrO2. We argue that an interplay of strong
spin-orbit coupling and a Coulomb repulsion gives rise to an insulating ground
state as in a layered perovskite Sr2IrO4.Comment: 9 pages, 3 figure
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