Reversing a polyhedral surface by origami-deformation

AbstractWe introduce a new variety of flexatube, a rhombotube. It is obtained from a cardboard rhombohedron consisting of six rhombi with interior angles 60∘ and 120∘, by removing a pair of opposite faces, and then subdividing the remaining four faces by pairs of diagonals. It is reversible, that is, it can be turned inside out by a series of folds, using edges and diagonals of the rhombi. To turn a rhombotube inside out is quite a challenging puzzle. We also consider the reversibility of general polyhedral surfaces. We show that if an orientable polyhedral surface with boundary is reversible, then its genus is 0, and for every interior vertex, the sum of face angles at the vertex is at least 2π. After defining the tube-attachment operation, we show that every polyhedral surface obtained from a rectangular tube by applying tube-attachment operations one after another, can be subdivided so that it becomes reversible

Inactivation of Vibrio vulnificus hemolysin through mutation of the N- or C-terminus of the lectin-like domain

Vibrio vulnificus is an etiological agent causing serious systemic infections in the immunocompromised humans or cultured eels. This species commonly produces a hemolytic toxin consisting of the cytolysin domain and the lectin-like domain. For hemolysis, the lectin-like domain specifically binds to cholesterol in the erythrocyte membrane, and to form a hollow oligomer, the toxin is subsequently assembled on the membrane. The cytolysin domain is essential for the process to form the oligomer. Three-dimensional structure model revealed that two domains connected linearly and the C-terminus was located near to the joint of the domains. Insertion of amino acid residues between two domains was found to cause inactivation of the toxin. In the C-terminus, deletion, substitution or addition of an amino acid residue also elicited reduction of the activity. However, the cholesterol-binding ability was not affected by the mutations. These results suggest that mutation of the C- or N-terminus of the lectin-like domain may result in blockage of the toxin assembly

Tissue-specific expression of histone H3 variants diversified after species separation

Additional file 3: Predicted CDS of human histone H3/H4 variants, contains Table S2, which lists the CDS locus information of the predicted human histone H3 and H4 variants in an Excel file

Laparoscopic Gastrectomy for Gastric Cancer with Peritoneal Dissemination after Induction Chemotherapy

Gastric cancer with peritoneal dissemination may be diagnosed as unresectable. More recently, as a result of progress in chemotherapy, some patients with peritoneal dissemination have exhibited extended survival. We report on our experience with three patients in whom induction chemotherapy allowed for totally laparoscopic total gastrectomy (TLTG). All three patients were diagnosed as having advanced gastric cancer with peritoneal dissemination using staging laparoscopy. As induction chemotherapy, S-1 combined with cisplatin was administered to two patients and trastuzumab plus capecitabine combined with cisplatin to one patient. TLTG was performed in all patients and there were no postoperative complications. Adjuvant chemotherapy was initiated within 3 weeks after surgery in all three patients. Laparoscopic gastrectomy undertaken after induction chemotherapy was found to be effective and safe; this treatment has the potential to achieve good treatment outcomes in patients with stage IV gastric cancer

Discovery of Negative Superhumps during a Superoutburst of January 2011 in ER Ursae Majoris

We report on a discovery of "negative" superhumps during the 2011 January superoutburst of ER UMa. During the superoutburst which started on 2011 January 16, we detected negative superhumps having a period of 0.062242(9) d, shorter than the orbital period by 2.2%. No evidence of positive superhumps was detected during this observation. This finding indicates that the disk exhibited retrograde precession during this superoutburst, contrary to all other known cases of superoutbursts. The duration of this superoutburst was shorter than those of ordinary superoutbursts and the intervals of normal outbursts were longer than ordinary ones. We suggest a possibility that such unusual outburst properties are likely a result of the disk tilt, which is supposed to be a cause of negative superhumps: the tilted disk could prevent the disk from being filled with materials in the outmost region which is supposed to be responsible for long-duration superoutbursts in ER UMa-type dwarf novae. The discovery signifies the importance of the classical prograde precession in sustaining long-duration superoutbursts. Furthermore, the presence of pronounced negative superhumps in this system with a high mass-transfer rate favors the hypothesis that hydrodynamical lift is the cause of the disk tilt.Comment: 8 pages, 3 figures, Accepted for publication in PASJ Lette

Ictal direct current shifts contribute to defining the core ictal focus in epilepsy surgery

難治てんかん焦点の新しいバイオマーカー「発作時DC電位」 --国内5施設の共同研究での世界初の成果--. 京都大学プレスリリース. 2022-09-05.Identifying the minimal and optimal epileptogenic area to resect and cure is the goal of epilepsy surgery. To achieve this, EEG analysis is recognized as the most direct way to detect epileptogenic lesions from spatiotemporal perspectives. Although ictal direct-current shifts (icDCs; below 1 Hz) and ictal high-frequency oscillations (icHFOs; above 80 Hz) have received increasing attention as good indicators that can add more specific information to the conventionally defined seizure-onset zone, large cohort studies on postoperative outcomes are still lacking. This work aimed to clarify whether this additional information, particularly icDCs which is assumed to reflect extracellular potassium concentration, really improve postoperative outcomes. To assess the usefulness in epilepsy surgery, we collected unique EEG datasets recorded with a longer time constant of 10 sec using an alternate current amplifier. 61 patients [15 with mesial temporal lobe epilepsy and 46 with neocortical epilepsy] who had undergone invasive presurgical evaluation for medically refractory seizures at five institutes in Japan, were retrospectively enrolled in this study. Among intracranially implanted electrodes, the two core electrodes of both icDCs and icHFOs were independently identified by board-certified clinicians based on unified methods. The occurrence patterns, such as their onset time, duration, and amplitude (power) were evaluated to extract the features of both icDCs and icHFOs. Additionally, we examined whether the resection ratio of the core electrodes of icDCs and icHFOs independently correlated with favorable outcomes. A total of 53 patients with 327 seizures were analyzed for wide-band EEG analysis, and 49 patients were analyzed for outcome analysis. icDCs were detected in the seizure-onset zone more frequently than icHFOs among both patients (92% vs. 71%) and seizures (86% vs. 62%). Additionally, icDCs significantly preceded icHFOs in patients exhibiting both biomarkers, and icDCs occurred more frequently in neocortical epilepsy patients than in mesial temporal lobe epilepsy patients. Finally, although a low corresponding rate was observed for icDCs and icHFOs (39%) at the electrode level, complete resection of the core area of icDCs significantly correlated with favorable outcomes, similar to icHFO outcomes. Our results provide a proof of concept that the independent significance of icDCs from icHFOs should be considered as reliable biomarkers to achieve favorable outcomes in epilepsy surgery. Moreover, the different distribution of the core areas of icDCs and icHFOs may provide new insights into the underlying mechanisms of epilepsy, in which not only neurons but also glial cells may be actively involved via extracellular potassium levels