動脈硬化豚の実験モデルにおける冠動脈形成術後の血管反応性と再狭窄について

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Preliminary outcomes of primary phacoemulsification plus intraocular lens implantation for primary angleclosure glaucoma

Purpose : To evaluate effects and safety of primary phacoemulsification plus intraocular lens implantation for controlled chronic angle-closure glaucoma (CACG) or primary angle-closure (PAC). Design : Prospective, non-randomized comparative trial. Methods : Two treatment groups were used. The IOL group included the use of phacoemulsification plus intraocular lens (IOL) implantation in 27 eyes. The LI group included treatment by laser iridotomy (LI) in 23 eyes. Intraocular pressure (IOP), numbers of antiglaucoma medications, complications, and corneal endothelial cell counts were examined in each group. Results : In the IOL group, IOP was significantly reduced from a preoperative mean of 14.8±4.2 mmHg to a 6-month-postoperative mean of 10.8±1.6 mmHg (P ＜.05). However, in the LI group, mean preoperative IOP was 15.5±4.1 mmHg, and the 6-month-postoperative IOP was 14.7±4.7 mmHg (P = .76). In the IOL group, no patient used anti-glaucoma medications 6-month postoperatively, whereas in the LI group, mean number of anti-glaucoma medications was 0.2±0.4 (P ＜.05). There were no significant differences in preoperative and postoperative corneal endothelial cell counts between IOL and LI groups (P = .39). Conclusions : Primary phacoemulsification plus intraocular lens implantation for controlled CACG or PAC seems to be a safe and effective method in reducing IOP. This procedure might become the first treatment of choice for controlled CACG or PAC with cataract

Synergistic Pathogenic Effects of Combined Mouse Monoclonal Anti-Desmoglein 3 IgG Antibodies on Pemphigus Vulgaris Blister Formation

Pemphigus vulgaris (PV) is an autoimmune blistering disease caused by anti-desmoglein 3 (Dsg3) IgG antibodies. Previously, we generated an active mouse model for PV by adoptive transfer of splenocytes from immunized or naive Dsg3−/− mice. In this study, we isolated 10 anti-Dsg3 IgG mAbs (NAK-series) from PV model mice generated by transfer of naive Dsg3−/− splenocytes. We characterized their epitopes using domain-swapped and point-mutated Dsg1/Dsg3 molecules and examined their pathogenic activities in blister formation in three different assays. In a passive transfer model using neonatal mice, eight of 10 NAK mAbs showed pathogenic activity when injected together with half the minimum pathogenic dose of anti-Dsg1 IgG autoantibodies from pemphigus foliaceus (PF) patients. None of the mAbs could induce the PV phenotype when individual hybridoma clones were inoculated by peritoneal injection into adult Rag2−/− mice. NAK mAbs displayed a range of potency in an in vitro dissociation assay using primary cultured mouse keratinocytes. Interestingly, when multiple hybridoma clones recognizing different epitopes were inoculated in combination, recipient mice developed the PV phenotype. In vitro dissociation assays confirmed that combined NAK mAbs had synergistic pathogenic effects. These findings indicate that although an individual anti-Dsg3 IgG is not sufficient to cause blistering in adult mice, several together can induce the PV phenotype. These mAbs will provide a valuable tool to investigate the molecular mechanisms of blister formation, mimicking the effects of the polyclonal IgG antibodies found in patients

Immunohistochemical Examination on the Distribution of Cells Expressed Lymphatic Endothelial Marker Podoplanin and LYVE-1 in the Mouse Tongue Tissue

The clinical study for lingual disease requires the detailed investigation of the lingual lymphatic network and lymphatic marker-positive cells. Recently, it has been reported that several tissue cells and leukocytes express lymphatic markers, LYVE-1 and podoplanin. This study was aimed to clarify the lingual distribution of cells expressing LYVE-1 and podoplanin. In the mouse tongue, podoplanin is expressed in nerve sheaths, lingual gland myoepithelial cells, and lymphatic vessels. LYVE-1 is expressed in the macrophage marker Mac-1-positive cells as well as lymphatic vessels, while factor-VIII was detected in only blood endothelial cells. α-SMA was detected in vascular smooth muscle and myoepithelial cells. Therefore, identification of lymphatic vessels in lingual glands, the combination of LYVE-1 and factor-VIII, or LYVE-1 and Mac-1 is useful because myoepithelial cells express podoplanin and α-SMA. The immunostaining of factor-VIII on lymphatic vessels was masked by the immunostaining to LYVE-1 or podoplanin because lymphatic vessels express factor-VIII to a far lesser extent than blood vessels. Therefore, except for the salivary glands, the combination of podoplanin and α-SMA, or factor-VIII is useful to identify lymphatic vessels and blood vessels with smooth muscle, or blood capillaries

A Rare Case of a Symptomatic Tumor Found in the Groin Area : An Atypical Location Unexposed to the Known Causes

Nevoid basal cell carcinoma syndrome (NBCCS), also known as Gorlin syndrome, is a rare hereditary condition characterized by a wide range of developmental abnormalities and a predisposition to neoplasms. The syndrome consists of early-onset and/or multiple BCC. Herein we report a rare NBCCS case in which the first BCC onset occurred in the groin area. To the best of our knowledge, there have been no reports of first-onset BCC in the groin area in an NBCCS patient of any race

Electric spectroscopy of vortex states and dynamics in magnetic disks

Spin-polarized radio frequency (RF) currents and RF-Oersted fields resonantly excite a magnetic vortex core confined in a micron-scale soft magnetic disk. In this study, we measured the rectifying voltage spectra caused by the anisotropic magnetoresistance oscillation due to the gyration of the vortex with different polarity and chirality. The measured spectra are presented such that we can determine the vortex properties and strength of the spin torques and Oersted field accurately and directly through analytical calculation.Comment: 39 pages,1 table, 10 figure

Anti-tachycardia pacing degenerated fast ventricular tachycardia into undetectable life-threatening tachyarrhythmia in a patient with non-ischemic dilated cardiomyopathy

SummaryA 45-year-old man with dilated cardiomyopathy was admitted to our hospital due to congestive heart failure (CHF). Despite the optimal medical treatment, his condition had not improved because of severe left ventricular dysfunction. Because he experienced non-sustained ventricular tachycardia (VT), a biventricular implantable cardioverter-defibrillator (Bi-V ICD) was implanted for reduction of dyssynchrony and primary prevention of lethal tachyarrhythmia. After discharge, he developed CHF and was transported to our hospital by ambulance. In the ambulance, monomorphic sustained VT with 200bpm suddenly occurred. The ICD detected it as fast VT and anti-tachycardia pacing (ATP) was delivered. After the ATP therapy, RR intervals of VT became irregular and prolonged. Ventricular fibrillation-like electrical activity was recorded by a far-field electrogram from the defibrillator, but the tachycardia cycle length exceeded 400ms which is under the tachycardia detection rate. The device failed to deliver a shock and the patient had to be rescued with an external shock. This is a rare case of fast VT that degenerated into undetectable life-threatening tachyarrhythmia by ATP

Quantization of Even-Dimensional Actions of Chern-Simons Form with Infinite Reducibility

We investigate the quantization of even-dimensional topological actions of Chern-Simons form which were proposed previously. We quantize the actions by Lagrangian and Hamiltonian formulations {\`a} la Batalin, Fradkin and Vilkovisky. The models turn out to be infinitely reducible and thus we need infinite number of ghosts and antighosts. The minimal actions of Lagrangian formulation which satisfy the master equation of Batalin and Vilkovisky have the same Chern-Simons form as the starting classical actions. In the Hamiltonian formulation we have used the formulation of cohomological perturbation and explicitly shown that the gauge-fixed actions of both formulations coincide even though the classical action breaks Dirac's regularity condition. We find an interesting relation that the BRST charge of Hamiltonian formulation is the odd-dimensional fermionic counterpart of the topological action of Chern-Simons form. Although the quantization of two dimensional models which include both bosonic and fermionic gauge fields are investigated in detail, it is straightforward to extend the quantization into arbitrary even dimensions. This completes the quantization of previously proposed topological gravities in two and four dimensions.Comment: 50 pages, latex, no figure