Novel Charge Ordering in the Trimer Iridium Oxide BaIrO3

We have prepared polycrystalline samples of the trimer Ir oxide BaIrO3 with face-shared Ir3O12 trimers, and have investigated the origin of the phase transition at 182 K by measuring resistivity, thermopower, magnetization and synchrotron x-ray diffraction. We propose a possible electronic model and transition mechanism, starting from a localized electron picture on the basis of the Rietveld refinement. Within this model, BaIrO3 can be basically regarded as a Mott insulator, when the Ir3O12 trimer is identified to one pseudo-atom or one lattice site. The transition can be viewed as a transition from the Mott insulator phase to a kind of charge ordered insulator phase.Comment: 8 pages 5 figures, Crystals (in press

A Study of Regional Resource Utilization in Vocational Education of Special Needs Education High School Division: Based on efforts utilizing employment assistance conference and subsequent advice

本報告では、平成28年度に広島県内初の肢体不自由教育と知的障害教育に対応した併置校として新たにスタートした本校の地域資源を活用した職業教育の実践について述べる。この取組は、進路指導部を中核とした「就労支援プロジェクト」として展開している。このプロジェクトでは、地域資源とのネットワークを促進させ就労支援の充実を図ることを目的に、「就労支援会議」と「企業参観日」を開催している。初年度この会議に参加された方々から頂いた助言を基に、主に３つの取組を展開した。広島県特別支援学校技能検定で身に付けた力を日常生活の中でどのように般化し、主体的に応用できるかを目指した「技能検定に係る下学部への指導」、現場で得た課題を授業の中で整理、理解、改善して、再度現場で実践し、課題を克服することを目指した「グループ実習」、就労支援会議構成員との面談を通して、自己への気付きを深めていく「グループ面談」について、その具体的な実践内容について報告する。In this report, the authors describe the practices of vocational education utilizing regional resources at our school, re-established in 2017 as the first co-location school in Hiroshima Prefecture, that corresponds to both education for orthopedically impaired students and education for mentally retarded students. This approach is organized as an “employment assistance project” led by the career guidance department at its central core. In this project, the authors hold an“ employment assistance conference” and a“ company visit day” in order to further promote networking with regional resources and to enhance productive employment support. Based on advice from the conference participants in the first year, the authors developed three further approaches. The authors hereby describe the specific practices as such: “guidance to the lower division students associating with skill test” that focuses on how to generalize and proactively apply in daily life, the skills absorbed through the Hiroshima Prefectural Special Needs Education School Skill Test;“ group training” that aims towards overcoming challenges found in the training through the process of organizing, understanding, improving and practicing again onsite, and “group interview” that encourages deeper awareness of oneself through interview exchanges with employment assistance conference members

EMAによる調音運動観測のための咬合面と口蓋の計測法

国立国語研究所甲南大学早稲田大学千葉工業大学国立国語研究所National Institute for Japanese Language and LinguisticsKonan UniversityWaseda UniversityChiba Institute of TechnologyNational Institute for Japanese Language and Linguistic

Cyanobacterial Cell Lineage Analysis of the Spatiotemporal hetR Expression Profile during Heterocyst Pattern Formation in Anabaena sp. PCC 7120

Diazotrophic heterocyst formation in the filamentous cyanobacterium, Anabaena sp. PCC 7120, is one of the simplest pattern formations known to occur in cell differentiation. Most previous studies on heterocyst patterning were based on statistical analysis using cells collected or observed at different times from a liquid culture, which would mask stochastic fluctuations affecting the process of pattern formation dynamics in a single bacterial filament. In order to analyze the spatiotemporal dynamics of heterocyst formation at the single filament level, here we developed a culture system to monitor simultaneously bacterial development, gene expression, and phycobilisome fluorescence. We also developed micro-liquid chamber arrays to analyze multiple Anabaena filaments at the same time. Cell lineage analyses demonstrated that the initial distributions of hetR::gfp and phycobilisome fluorescence signals at nitrogen step-down were not correlated with the resulting distribution of developed heterocysts. Time-lapse observations also revealed a dynamic hetR expression profile at the single-filament level, including transient upregulation accompanying cell division, which did not always lead to heterocyst development. In addition, some cells differentiated into heterocysts without cell division after nitrogen step-down, suggesting that cell division in the mother cells is not an essential requirement for heterocyst differentiation

The ASTRO-H X-ray Observatory

The joint JAXA/NASA ASTRO-H mission is the sixth in a series of highly successful X-ray missions initiated by the Institute of Space and Astronautical Science (ISAS). ASTRO-H will investigate the physics of the high-energy universe via a suite of four instruments, covering a very wide energy range, from 0.3 keV to 600 keV. These instruments include a high-resolution, high-throughput spectrometer sensitive over 0.3-2 keV with high spectral resolution of Delta E < 7 eV, enabled by a micro-calorimeter array located in the focal plane of thin-foil X-ray optics; hard X-ray imaging spectrometers covering 5-80 keV, located in the focal plane of multilayer-coated, focusing hard X-ray mirrors; a wide-field imaging spectrometer sensitive over 0.4-12 keV, with an X-ray CCD camera in the focal plane of a soft X-ray telescope; and a non-focusing Compton-camera type soft gamma-ray detector, sensitive in the 40-600 keV band. The simultaneous broad bandpass, coupled with high spectral resolution, will enable the pursuit of a wide variety of important science themes.Comment: 22 pages, 17 figures, Proceedings of the SPIE Astronomical Instrumentation "Space Telescopes and Instrumentation 2012: Ultraviolet to Gamma Ray

リアルタイムMRI動画日本語調音運動データベースの設計

National Institute for Japanese Language and LinguisticsNational Institute for Japanese Language and LinguisticsWaseda UniversityNational Institute for Japanese Language and LinguisticsATR-PromotionsATR-PromotionsChiba Institute of TechnologyKonan UniversityTakushoku UniversityNational Institute for Japanese Language and LinguisticsNational Institute for Japanese Language and LinguisticsWaseda UniversityWaseda UniversityPicolab会議名: 言語資源活用ワークショップ2020, 開催地: オンライン, 会期: 2020年9月8日−9日, 主催: 国立国語研究所 コーパス開発センターわれわれは、日本語に関する調音音声学的研究の新しいインフラ提供をめざして、調音運動データベースの構築を進めてきている。声道全体の形状変化を毎秒14 ないし25 フレームのリアルタイムMRI 動画として記録したデータが、現時点で東京方言16 名、近畿方言5名分収録済である。1 名あたりの発話量は25〜30 分である。データには個々の発話の開始時刻と終了時刻のタグが付与されており、他に発話内容と話者に関するメタデータを検索に利用できる

Hitomi (ASTRO-H) X-ray Astronomy Satellite

The Hitomi (ASTRO-H) mission is the sixth Japanese x-ray astronomy satellite developed by a large international collaboration, including Japan, USA, Canada, and Europe. The mission aimed to provide the highest energy resolution ever achieved at E  >  2  keV, using a microcalorimeter instrument, and to cover a wide energy range spanning four decades in energy from soft x-rays to gamma rays. After a successful launch on February 17, 2016, the spacecraft lost its function on March 26, 2016, but the commissioning phase for about a month provided valuable information on the onboard instruments and the spacecraft system, including astrophysical results obtained from first light observations. The paper describes the Hitomi (ASTRO-H) mission, its capabilities, the initial operation, and the instruments/spacecraft performances confirmed during the commissioning operations for about a month

DOCK2 is involved in the host genetics and biology of severe COVID-19

「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target