DNAナノ構造体による機能性分子の組織化と区画化

京都大学新制・課程博士博士(エネルギー科学)甲第25400号エネ博第479号京都大学大学院エネルギー科学研究科エネルギー基礎科学専攻(主査)教授 森井 孝, 教授 片平 正人, 教授 佐川 尚学位規則第4条第1項該当Doctor of Energy ScienceKyoto UniversityDGA

In Vitro Support of Primary Leukemia Cells

No in vitro method for culturing Primary Leukemia Cells exists. Thus, study of Primary Leukemia biology requires immunodeficient mouse models, which is costly and time consuming. Identifying a method to grow and maintain Primary Leukemia Cells in vitro would allow biological and molecular assays to facilitate bench to bedside translation

Electrochemical performance of a lead fluoride electrode mixed with carbon in an electrolyte containing triphenylboroxine as an anion acceptor for fluoride shuttle batteries

In fluoride shuttle batteries (FSBs), the addition of an anion acceptor (AA) is required to dissolve the supporting electrolyte salt in an organic solvent. Based on theoretical calculations and practical experiments, the effectiveness of triphenylboroxine (TPhBX) as an AA for FSB was verified. Using an electrolyte with TPhBX as an AA, the specific capacities of the following two types of lead fluoride (PbF₂) electrodes were evaluated: (i) PbF₂ pulverized using a ball mill, (ii) pulverized PbF₂ mixed with carbon using a ball mill. The experimental results indicate that mixing PbF₂ with carbon using a ball mill increases the specific capacity of PbF₂ electrode

Electrochemical properties of lead fluoride electrode in fluoride shuttle battery

Recently, the reversible discharge and charge reaction of BiF₃ electrode for fluoride shuttle battery (FSB) that can be used as a promising candidate for next-generation battery are observed using a liquid-based electrolyte. In this study, we investigate the electrochemical performance of PbF₂ as an active material for the FSB. To increase the electronic conductivity, the PbF₂ was mixed with carbon, and the composite material between PbF₂ and carbon, PbF₂/C, is formed. High discharge and charge capacities are obtained for PbF₂/C during the first cycle. Although the discharge and charge capacities gradually decreased, the discharge and charge reactions occurred in the second and third cycles. To confirm the progress of the discharge and charge reactions, the crystal structure change of the active material during discharging and charging in the first and second cycles is evaluated using X-ray diffraction (XRD). From the XRD results, the formation of Pb and PbF₂ during discharging and charging can be confirmed, indicating that the discharge (PbF₂ + 2e− → Pb + 2F−) and charge (Pb + 2F− → PbF₂ + 2e−) reactions progress in both the first and second cycles

Geometric transitions, Chern-Simons gauge theory and Veneziano type amplitudes

We consider the geometric transition and compute the all-genus topological string amplitudes expressed in terms of Hopf link invariants and topological vertices of Chern-Simons gauge theory. We introduce an operator technique of 2-dimensional CFT which greatly simplifies the computations. We in particular show that in the case of local Calabi-Yau manifolds described by toric geometry basic amplitudes are written as vacuum expectation values of a product vertex operators and thus appear quite similar to the Veneziano amplitudes of the old dual resonance models. Topological string amplitudes can be easily evaluated using vertex operator algebra.Comment: 16 pages, 2 figures, (v2,3) minor changes, to appear in Phys. Lett.

Improved electrochemical performances in a bismuth fluoride electrode prepared using a high energy ball mill with carbon for fluoride shuttle batteries

Bismuth fluoride (BiF₃) is a promising positive electrode material for fluoride shuttle batteries (FSBs) owing to its high theoretical specific capacity (302 mA h g⁻¹). However, it exhibits low practical capacity. The methods for preparing the electrode are known to have significant effects on battery performance. The mixture between BiF₃ and carbon, BiF₃/C, prepared by high energy ball milling method has been already approved in lithium ion batteries. With this method, a significant improvement over the discharge and charge capacities of the BiF₃/C electrode has been achieved. In this work, for the first time, BiF₃/C electrode has been used for FSB. Using BiF₃/C electrode significantly increased the discharge and charge capacities. To confirm the progress of the discharge and charge reactions of BiF3/C electrode, the crystal structure of active materials and oxidation state of Bi for the BiF₃/C electrode during discharging and charging has been investigated by X-ray diffraction and X-ray absorption fine structure. The results reveal that, with higher capacity values, discharge and charge reactions related to BiF₃/C have been realized

Infiltration of T Lymphocytes and Expression of ICAM-1 in the Hippocampus of Patients with Hippocampal Sclerosis

We and others have previously shown that reactive microglia express the major histocompatibility complex (MHC) class I and class II antigens in the hippocampus of patients suffering from epilepsy. Although the MHC glycoproteins serve as restriction elements for T lymphocytes, there is little information available regarding T lymphocytes in hippocampal sclerosis. In the present study, we investigated T lymphocyte infiltration in human hippocampi in four cases of epilepsy with hippocampal sclerosis, as well as in four control cases without neurological disease. No CD8- or CD4-positive T lymphocytes were seen in hippocampi from the control cases. In contrast, CD8- and CD4-positive T lymphocytes had infiltrated into the hippocampi of patients with hippocampal sclerosis. In addition, expression of intercellular adhesion molecule-1 was diffusely upregulated in the hippocampi with hippocampal sclerosis. These results indicate that T lymphocyte infiltration is involved in the pathology of hippocampal sclerosis

Amiloride Derivative Compound 10357 in the Treatment of B-Cell Acute Lymphoblastic Leukemia

Compound 10357 is an amiloride derivative with potential promise as an adjunct to current chemotherapeutics. This study investigates the therapeutic efficacy of Compound 10357 in B-Cell Acute Lymphoblastic Leukemia (B-ALL)