Relationship Between Early Feeding and Communication Development in Infants: Birth To 12 Months

Introduction: Anecdotal reports suggest that infants experiencing early feeding difficulties may have delays in communication development. Methods: The first stage of the study involved the development of a theoretically based assessment protocol to test the hypothesis of linked or independent processes required for feeding and speech. The assessment protocol will be piloted on 10 full term and 10 preterm infants at birth, 4, 8 and 12 months post term age. Measures of inter-judge and intra-judge reliability will also be taken of the observation protocol. Observation of the infant\u27s language, speech, environment and maternal relationship will also be conducted to determine the nature and impact of environmental and social factors on feeding and/or speech and language development. Results: To be analysed. Conclusion: It is hypothesised that infants experiencing early feeding difficulties and delay will also experience later speech and language delay. Massey, S. J., Hird, K. M., & Simmer, K. (2004). Relationship between early feeding and communication development in infants: Birth to 12 months. Journal of Pediatric Gastroenterology and Nutrition, 39(2), 227-228. ISSN: 0277-2116 Abstract only available for downloa

Detecting changes in sediment overburden using distributed temperature sensing: an experimental and numerical study

Fibre optic cables can be used as sensors to monitor temperature changes through the analysis of back scattered light. This can be linked to changes in the ambient conditions surrounding the fibre optic cable. Active distributed temperature sensing relies on an external heat source relative to the fibre optic cable to measure the properties of, and changes in, the surrounding medium. An experiment was conducted using distributed temperature sensing technology to monitor changes in sediment overburden for the purpose of determining whether scour could be measured above buried power cables containing fibre optic cables. Fibre optic cables were buried in a channel containing saturated sand and water with an external heat source. The depth of overburden sediment above the fibre optic cables was reduced, whilst the associated temperature response along the fibre optic cable was monitored. The data was matched to a finite element model so that the heat transfer taking place could be simulated and then the thermal conductivity of the soil modified to observe the potential changes in heat detected by the fibre optic cables. This paper explains the characteristics of heat transfer from an active heat source to the surrounding soil medium providing a means to translate the temperature measurement to the associated overburden thickness and to model the same response in different materials

Boundary effects of expectation in human pain perception

Funder: RCUK | Medical Research Council (MRC); doi: https://doi.org/10.13039/501100000265Funder: FONDECYT, 1161378Abstract: Perception of sensory stimulation is influenced by numerous psychological variables. One example is placebo analgesia, where expecting low pain causes a painful stimulus to feel less painful. Yet, because pain evolved to signal threats to survival, it should be maladaptive for highly-erroneous expectations to yield unrealistic pain experiences. Therefore, we hypothesised that a cue followed by a highly discrepant stimulus intensity, which generates a large prediction error, will have a weaker influence on the perception of that stimulus. To test this hypothesis we collected two independent pain-cueing datasets. The second dataset and the analysis plan were preregistered (https://osf.io/5r6z7/). Regression modelling revealed that reported pain intensities were best explained by a quartic polynomial model of the prediction error. The results indicated that the influence of cues on perceived pain decreased when stimulus intensity was very different from expectations, suggesting that prediction error size has an immediate functional role in pain perception

Enhancing accuracy and precision of transparent synthetic soil modelling

Over recent years non-intrusive modelling techniques have been developed to investigate soil-structure interaction problems of increasingly complex geometry. This paper concerns the development of a small-scale, 1 g, modelling technique using a transparent analogue for soil with particle image velocimetry for internal displacement measurement. Larger model geometry achieved in this research using fine-grained transparent synthetic soils has led to an increased need for rigorous photogrammetric correction techniques. A correction framework, based upon a modified version of the pinhole camera model, is presented that corrects for lens and camera movement induced errors as well as scaling from image space to object space. An additional statistical approach is also developed to enhance the system precision, by minimising the impact of increased non-coplanarity between the photogrammetry control plane and the target plane. The enhanced data correction and statistical precision is demonstrated using a case study examining the failure mechanism around a double helical screw pile installed in transparent synthetic soil representative of a soft clay

Fosmidomycin Decreases Membrane Hopanoids and Potentiates the Effects of Colistin on Burkholderia multivorans Clinical Isolates

Burkholderia cepacia complex (Bcc) pulmonary infections in people living with cystic fibrosis (CF) are difficult to treat because of the extreme intrinsic resistance of most isolates to a broad range of antimicrobials. Fosmidomycin is an antibacterial and antiparasitic agent that disrupts the isoprenoid biosynthesis pathway, a precursor to hopanoid biosynthesis. Hopanoids are involved in membrane stability and contribute to polymyxin resistance in Bcc bacteria. Checkerboard MIC assays determined that although isolates of the Bcc species B. multivorans were highly resistant to treatment with fosmidomycin or colistin (polymyxin E), antimicrobial synergy was observed in certain isolates when the antimicrobials were used in combination. Treatment with fosmidomycin decreased the MIC of colistin for isolates as much as 64-fold to as low as 8 μg/ml, a concentration achievable with colistin inhalation therapy. A liquid chromatography-tandem mass spectrometry technique was developed for the accurate quantitative determination of underivatized hopanoids in total lipid extracts, and bacteriohopanetetrol cyclitol ether (BHT-CE) was found to be the dominant hopanoid made by B. multivorans. The amount of BHT-CE made was significantly reduced upon fosmidomycin treatment of the bacteria. Uptake assays with 1-N-phenylnaphthylamine were used to determine that dual treatment with fosmidomycin and colistin increases membrane permeability, while binding assays with boron-dipyrromethene-conjugated polymyxin B illustrated that the addition of fosmidomycin had no impact on polymyxin binding. This work indicates that pharmacological suppression of membrane hopanoids with fosmidomycin treatment can increase the susceptibility of certain clinical B. multivorans isolates to colistin, an agent currently in use to treat pulmonary infections in CF patients

The Middle Way: East Asian masters students’ perceptions of critical argumentation in U.K. universities.

The paper explores the learning experiences of East Asian masters students in dealing with Western academic norms of critical thinking in classroom debate and assignment writing. The research takes a cultural approach, and employs grounded theory and case study methodology, the aims being for students to explain their perceptions of their personal learning journeys. The data suggest that the majority of students interviewed rejected full academic acculturation into Western norms of argumentation. They instead opted for a ‘Middle Way’ that synergizes the traditional cultural academic values held by many East Asian students with those elements of Western academic norms that are perceived to be aligned with these. This is a relatively new area of research which represents a challenge for British lecturers and students

Calculation of the properties of the rotational bands of 155,157^{155,157}Gd

We reexamine the long-standing problem of the microscopic derivation of a particle-core coupling model. We base our research on the Klein-Kerman approach, as amended by D\"onau and Frauendorf. We describe the formalism to calculate energy spectra and transition strengths in some detail. We apply our formalism to the rotational nuclei $^{155,157}$Gd, where recent experimental data requires an explanation. We find no clear evidence of a need for Coriolis attenuation.Comment: 27 pages, 13 uuencoded postscript figures. Uses epsf.st

Early life mortality in East London: a feasibility study. Summary report. Fetal and Infant Death in East London

This report summarises a feasibility study for further research to increase the understanding of the causes of the high rates of stillbirth and infant mortality in East London in order to inform action aimed at reducing them. The project consisted of three parts, a review of previous research and published data, analyses of routine data derived from notification of births to women living in City and Hackney, Tower Hamlets and Newham and a review of case notes at the Homerton University Hospital and the Royal London Hospital relating to late fetal losses and terminations, stillbirths and infant deaths. Fuller reports are available separately for the literature review, the case note review and the analyses of routine data for each of the three boroughs

The need for an integrated approach for chronic disease research and care in Africa.

With the changing distribution of infectious diseases, and an increase in the burden of non-communicable diseases, low- and middle-income countries, including those in Africa, will need to expand their health care capacities to effectively respond to these epidemiological transitions. The interrelated risk factors for chronic infectious and non-communicable diseases and the need for long-term disease management, argue for combined strategies to understand their underlying causes and to design strategies for effective prevention and long-term care. Through multidisciplinary research and implementation partnerships, we advocate an integrated approach for research and healthcare for chronic diseases in Africa

Many Body Theory of Charge Transfer in Hyperthermal Atomic Scattering

We use the Newns-Anderson Hamiltonian to describe many-body electronic processes that occur when hyperthermal alkali atoms scatter off metallic surfaces. Following Brako and Newns, we expand the electronic many-body wavefunction in the number of particle-hole pairs (we keep terms up to and including a single particle-hole pair). We extend their earlier work by including level crossings, excited neutrals and negative ions. The full set of equations of motion are integrated numerically, without further approximations, to obtain the many-body amplitudes as a function of time. The velocity and work-function dependence of final state quantities such as the distribution of ion charges and excited atomic occupancies are compared with experiment. In particular, experiments that scatter alkali ions off clean Cu(001) surfaces in the energy range 5 to 1600 eV constrain the theory quantitatively. The neutralization probability of Na$^+$ ions shows a minimum at intermediate velocity in agreement with the theory. This behavior contrasts with that of K$^+$, which shows ... (7 figures, not included. Figure requests: [email protected])Comment: 43 pages, plain TeX, BUP-JBM-