A possible case of maculopapular eruption associated with glecaprevir/pibrentasvir treatment for chronic hepatitis C virus infection

Tomiyasu et al. report a possible case of maculopapular eruption associated with G/P treatment. Based upon the clinical course and histological analysis, the present case may be mediated by allergic mechanism. Since G/P treatment is widely used because of its efficacy and safety, clinical dermatologists should be aware that G/P may cause cutaneous drug eruption mediated by allergic responses

Disseminating Practical and Operational Tools to Promote Monitor and Implement the Human Right to Adequate Housing

It is striking the huge gap between the dimension of adequate housing as a fundamental human right recognized by various international treaties and conventions and the real and effective incorporation of such concept in public policy developed by governments at all levels of the public administration and in the practices developed by different actors involved in housing programs and urban planning. By assuming the post of UN Special Rapporteur on the Right to Adequate Housing, professor Raquel Rolnik decided to dedicate efforts in this direction, to make public and accessible to various actors of society the tools and documents already produced by the International Rapporteur. For this purpose, she placed the matter on the agenda of research and extension developed at the School of Architecture and Urbanism of this University. The sub-theme chosen for the development of activities were the removals and forced evictions resulting from projects of infrastructure and urbanization. The material produced is presented as a guide and a leaflet, with a clear and accessible language, for the technicians of the public sector, non-governmental organizations, movements struggling for housing, students and teachers who work with the theme.É notável o enorme distanciamento entre a dimensão da moradia adequada como direito fundamental do ser humano (reconhecido por diferentes tratados e convenções internacionais) e a real e efetiva incorporação de tal conceito nas políticas públicas para o setor (por governos nacionais em todos os níveis da administração pública e nas práticas dos atores envolvidos em programas habitacionais e de planejamento urbano). Ao assumir o cargo de Relatora Especial para o Direito à Moradia Adequada da ONU, a Profa. Dra. Raquel Rolnik decidiu dedicar esforços neste sentido, para tornar pública e acessível aos diversos atores da sociedade as ferramentas e documentos já produzidos pela Relatoria Internacional. Para isto, inseriu o tema na agenda de pesquisa e extensão desenvolvida na Faculdade de Arquitetura e Urbanismo (FAU) da Universidade de São Paulo. O subtema escolhido para desenvolvimento das atividades foi o das remoções e despejos forçados resultantes de projetos de infraestrutura e urbanização. Como material resultante é apresentado um guia e folheto elaborados com linguagem clara e acessível, destinado aos técnicos do setor público e a organizações não governamentais, aos movimentos de luta pela moradia, aos estudantes e professores que trabalham com o tema

女子学生の食生活実態調査 : 平日と休日の比較

In general, researches on diet exclude meals taken on a day off. However, students usually have long holidays and some spend more than half a year as their holidays. This took place in May and June of Heisei 14. Weekdays are supposed to be from Monday to Friday, when classes are open, and days off are supposed to be Saturdays, Sundays and holidays, when there are no classes. We have got the following findings. 4.3% of students take no breakfast on weekdays and 18.7% of students on days off. Sleep is the major reason for taking no breakfast on days off. They get up one hour later than those who take breakfast. 14.5% of students take refreshments on days off as a means of communication. The rate is significantly higher than 1.6% on weekdays. On the other hand, it is remarkable that they have refreshments on weekdays to relieve the feeling of hunger. The length of their mealtime on days off increases in every meal compared with weekdays. They seem to take much time for meals on days off, and also there is a tendency that they spend longer time if they have someone with them when they take a meal. The result of the survey on intake of food is as follows. Sufficiency of energy is 93%. They take slightly more nutrients and variety of food on days off than on weekdays but there is no such significant difference between the two

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection

DOCK2 is involved in the host genetics and biology of severe COVID-19

「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target

Waste and urban centrality in São Paulo: a discussion about recyclable materials collectors from Glicério

A região central da cidade de São Paulo, a partir da flexibilização econômica dos anos 1990, tornou-se espaço de conflitos entre o desejo de permanência da população de menor renda e os interesses por uma nova frente de valorização imobiliária. Os reveses sentidos pelos movimentos sociais organizados e o recente afluxo de recursos internacionais no mercado imobiliário parecem negar qualquer possibilidade de atuação de sujeitos políticos, enquanto consolida a hegemonia do pensamento neoliberal de que não há alternativas além da ordem já colocada. Do mesmo modo as análises sociais urbanas produzidas a partir da mobilização social dos anos 1980, marcadas por uma visão industrial, se muito avançou na compreensão dos processos sociais de produção do urbano, pouco permite visualizar quanto aos nexos que contribuam para a superação de um quadro crescente de fragmentação social. Apesar desta conjuntura urbana, as contradições dessa mesma produção social permitem a permanência do uso da centralidade urbana do Glicério pelos catadores de materiais recicláveis. Esse que parece existir somente como mero produto social residual, junto à interpretação de Lefebvre sobre a produção do espaço como parte da reprodução das relações sociais de produção, mostra-se como uma experiência que tem reformulado representações centrais do fetiche da mercadoria. Permite-nos assim ampliar o olhar para além da visão industrial e das relações de produção da mais-valia, bem como dos determinantes da institucionalização do Estado. Pelo olhar urbano, uma coesão social diferencial mostra-se possível como práxis urbana, reabrindo o horizonte dos possíveis, na prática e na teoria.Since the 1990s, economic flexibility has transformed the central region of the city of São Paulo in an area of conflict. On one side there is low-income residents desire for permanence, on the other side there are real estate market interests in a new valorization frontier. Setbacks experienced by organized social movements and the recent influx of international capital in the housing market seem to deny any possibility of action for political subjects. These factors also seem to consolidate the hegemony of neoliberal thinking as subjects are left with no alternative to the order already in place. Marked by an industrial view, current and increasing urban social analysis on the social mobilization processes of the 1980s allow us a clear understanding of the social production of the city. Nevertheless, these accounts do not contribute to overcoming the increasing social fragmentation perceived in the city. Despite these factors, the contradictions of the social production of this urban space enable collectors of recyclable materials the permanent use of the urban centrality of the Glicério area. This use seems to exist only as a mere residual social product. Nevertheless, in Lefebvres account on the production of space as part of the reproduction of social relations of production, the use of Glicério by collectors shows up as an experience that has reshaped the central representations of the commodity fetish. This perspective on the use of this urban space allows us to view beyond industrial relations and the production of surplus value, as well as the determinants of state institutionalization. Through this urban point of view, a differential social cohesion shows up as a possible urban praxis, reopening the horizon of the possible, in practice and theory

Electrochemical oxidation of graphite in aqueous hydrofluoric acid solution at high current densities.

International audienceElectrochemical oxidation of graphite was performed at high current densities in 47% HF aqueous solution. Cyclic voltammetry indicated that covalent Csingle bondF bonding formed above 2.4 V vs Pb/PbF2. The sample obtained at higher current densities than 200 mA cm−2 was stage 1 type material with an interlayer spacing of 0.55 nm and it contained a considerable amount of oxygen, together with the covalently bonded fluorine. The discharge profile of this sample as a cathode of lithium primary battery was similar to that of C2.5F prepared under F2 gas atmosphere and the capacity reached 550 mAh g−1. This strongly indicated that not only fluorine but also oxygen in this sample was utilized