Financing Options for Devolved Government in the UK

This study provides a comprehensive overview of the financing options for devolved government in the UK. Starting with a discussion of the present situation, the consequences and the possible future of the Barnett formula, the key economic and political principles for devolution finance are examined and then applied to possible financing options. The conclusion draws together the main points of the analysis and comments on the alternatives for funding the devolved administrations. While currently there appears to be considerable cross-party support for the Barnett system, it continues to be a contentious arrangement, with some observers even talking of a “fiscal crisis” (McLean (2005)). The paper therefore reviews the strengths and weaknesses of the present system, together with suggestions for possible changes.

Re-designing a more circular Scottish economy

Policies to develop a more circular economy can unlock opportunities that change how businesses, supply chains and economies could operate in the 21st Century. Such approaches build on the application of earlier concepts of industrial ecology (Frosch and Gallopoulos, 1989), cradle-to-cradle (Braungart and MacDonough, 2002) and the performance economy (Stahel, 2010). This article explores the nature, benefits, barriers and enablers of the shift towards a more circular Scottish economy, drawing on the global evidence and the programme of research undertaken by the Scottish Government and its public sector partners. In particular, it assesses the nature and scale of the opportunities in two of Scotland’s growth sectors – oil & gas and the bioeconomy – and highlights the policy and evidence issues that will be important to support the transition to a more circular – and sustainable – Scottish economy

Controller design for the Navier-Stokes system. Part I: Concept & numerical results

We present a widely applicable construction recipe for closed-loop feedback controllers of nonlinear dynamical systems. Its basic idea consists in approximately solving certain instantaneous optimization problems for the discrete-in-time dynamical system. Easy incorporation of control constraints is one key feature of the recipe. The instationary Navier-Stokes equations serve as model application. In the first part of the work, we introduce the basic construction recipes and present numerical results for several closed-loop feedback control laws derived with the recipe. The stability analysis is contained in the second part of the work

Proving the unique fixed-point principle correct: an adventure with category theory

Abstract Say you want to prove something about an infinite data-structure, such as a stream or an infinite tree, but you would rather not subject yourself to coinduction. The unique fixed-point principle is an easyto-use, calculational alternative. The proof technique rests on the fact that certain recursion equations have unique solutions; if two elements of a coinductive type satisfy the same equation of this kind, then they are equal. In this paper we precisely characterize the conditions that guarantee a unique solution. Significantly, we do so not with a syntactic criterion, but with a semantic one that stems from the categorical notion of naturality. Our development is based on distributive laws and bialgebras, and draws heavily on Turi and Plotkin's pioneering work on mathematical operational semantics. Along the way, we break down the design space in two dimensions, leading to a total of nine points. Each gives rise to varying degrees of expressiveness, and we will discuss three in depth. Furthermore, our development is generic in the syntax of equations and in the behaviour they encode-we are not caged in the world of streams

Nano-structured transmissive spectral filter matrix based on guided-mode resonances

Background: In this work, a nanostructured guided-mode resonance filter matrix with high transmission efficiency and narrow bandwidth is demonstrated. The developed nano-filter arrays have various usages, e.g., combined with the CMOS image sensors to realize compact spectrometers for biomedical sensing applications. Methods: In order to optimize the filter performance, the spectral responses of filters with different structural parameters are carefully studied based on the variable-controlling method. A quality factor is carried out for quantitative characterization. Results: In this case, a high fill factor of 0.9 can strongly suppress sidebands, while buffer layer thickness can be adjusted to mainly control the bandwidth. The transmission peaks shift from 386 nm to 1060 nm with good linearity when periods vary from 220 nm to 720 nm. The incident angle dependence is simulated to be ~ 1.1 nm/degree in ±30° range. The filters are then fabricated and characterized. The results obtained from both simulations and experiments agree well, where the filters with the period of 352 nm exhibit simulated and measured transmission peaks of 564 nm and 536 nm, the FWHM of 13 nm and 17 nm, respectively. In terms of metal material, besides aluminum, silver is also investigated towards optimization of the transmission efficiency. Conclusion: The transmission spectra of designed filters have high transmission and low sideband; its peaks cover the whole visible and near infrared range. These characteristics allow them to have the possibility to be integrated into image sensors for spectrometer applications

Count me in: an inclusive approach towards patient recruitment for clinical research studies in the NHS

Background: Participation in clinical research is associated with better patient outcomes and higher staff retention and satisfaction rates. Nevertheless, patient recruitment to mental health studies is challenging due to a reliance on clinician or patient referrals (standard approach). To empower patients and make healthcare research more equitable, we explored a novel researcher-led approach, called ‘Count Me In’ (CMI). Objective: To evaluate a 12-month implementation of CMI in a routine clinical setting. Methods: CMI was launched in August 2021 in a mental health National Health Service (NHS) Trust in England. Patients (aged 18+) learnt about CMI at their initial clinical appointment. Unless they opted out, they became contactable for research (via research informatics searches). Findings: After 12 months, 368 patients opted out and 22 741 became contactable through CMI, including 2716 through the standard approach and 20 025 through electronic searches (637% increase). Of those identified via electronic searches, 738 were contacted about specific studies and 270 consented to participate. Five themes were identified based on patient and staff experiences of CMI: ‘level of awareness and accessibility of CMI’, ‘perceptions of research and perceived engagement with CMI’, ‘inclusive research practice’, ‘engagement and incentives for research participation’, and ‘relationships between clinical and research settings’. Conclusions: CMI (vs standard) led to a larger and diverse patient cohort and was favoured by patients and staff. Yet a shift in the NHS research culture is needed to ensure that this diversity translates to actual research participation. Clinical implications: Through collaboration with other NHS Trusts and services, key funders (National Institute for Health and Care Research) and new national initiatives (Office for Life Sciences Mental Health Mission), CMI has the potential to address recruitment challenges through rapid patient recruitment into time-sensitive country-wide studies

New standards for reducing gravity data: The North American gravity database

The North American gravity database as well as databases from Canada, Mexico, and the United States are being revised to improve their coverage, versatility, and accuracy. An important part of this effort is revising procedures for calculating gravity anomalies, taking into account our enhanced computational power, improved terrain databases and datums, and increased interest in more accurately defining long-wavelength anomaly components. Users of the databases may note minor differences between previous and revised database values as a result of these procedures. Generally, the differences do not impact the interpretation of local anomalies but do improve regional anomaly studies. The most striking revision is the use of the internationally accepted terrestrial ellipsoid for the height datum of gravity stations rather than the conventionally used geoid or sea level. Principal facts of gravity observations and anomalies based on both revised and previous procedures together with germane metadata will be available on an interactive Web-based data system as well as from national agencies and data centers. The use of the revised procedures is encouraged for gravity data reduction because of the widespread use of the global positioning system in gravity fieldwork and the need for increased accuracy and precision of anomalies and consistency with North American and national databases. Anomalies based on the revised standards should be preceded by the adjective “ellipsoidal” to differentiate anomalies calculated using heights with respect to the ellipsoid from those based on conventional elevations referenced to the geoid

Mislocalization of pathogenic RBM20 variants in dilated cardiomyopathy is caused by loss-of-interaction with Transportin-3

Severe forms of dilated cardiomyopathy (DCM) are associated with point mutations in the alternative splicing regulator RBM20 that are frequently located in the arginine/serine-rich domain (RS-domain). Such mutations can cause defective splicing and cytoplasmic mislocalization, which leads to the formation of detrimental cytoplasmic granules. Successful development of personalized therapies requires identifying the direct mechanisms of pathogenic RBM20 variants. Here, we decipher the molecular mechanism of RBM20 mislocalization and its specific role in DCM pathogenesis. We demonstrate that mislocalized RBM20 RS-domain variants retain their splice regulatory activity, which reveals that aberrant cellular localization is the main driver of their pathological phenotype. A genome-wide CRISPR knockout screen combined with image-enabled cell sorting identified Transportin-3 (TNPO3) as the main nuclear importer of RBM20. We show that the direct RBM20-TNPO3 interaction involves the RS-domain, and is disrupted by pathogenic variants. Relocalization of pathogenic RBM20 variants to the nucleus restores alternative splicing and dissolves cytoplasmic granules in cell culture and animal models. These findings provide proof-of-principle for developing therapeutic strategies to restore RBM20's nuclear localization in RBM20-DCM patients