DeWitt Wallace Library Annual Report 2013-2014

Summary of library and media services activities for 2013-201

DeWitt Wallace Library Annual Report 2016-2017

Summary of library and media services activities for 2016-201

DeWitt Wallace Library Biennial Report 2011-2013

Summary of library activities for 2011-201

DeWitt Wallace Library Annual Report 2014-2015

Summary of library and media services activities for 2014-201

Validation of the FluoroType MTBDR Assay for Detection of Rifampin and Isoniazid Resistance in Mycobacterium tuberculosis Complex Isolates.

For Mycobacterium tuberculosis complex (MTBC), the rapid and accurate diagnosis of drug resistance is crucial to ensure early initiation of appropriate therapy. Recently, a new molecular diagnostic test, the FluoroType MTBDR, aimed at detecting rifampin and isoniazid resistance has become available. This study aimed to evaluate the FluoroType MTBDR in comparison to phenotypic drug susceptibility testing (DST) using M. tuberculosis complex isolates. MTBC isolates underwent phenotypic DST and were tested using the FluoroType MTBDR and Genotype MTBDRplus. Sanger sequencing of the key regions of rpoB, katG, inhA, and aphC was performed for isolates with discordant phenotypic and molecular results. Furthermore, isolates with specific wild-type bands missing in the Genotype MTBDRplus, indicating the presence of a mutation, were investigated by Sanger sequencing. Specificity and sensitivity, defined as the proportions of isolates correctly determined as susceptible and resistant by the FluoroType MTBDR compared to phenotypic DST, were calculated. A total of 180 culture isolates were included; phenotypic DST showed 85 isolates susceptible to isoniazid and rifampin, 7 with isoniazid monoresistance, 7 with rifampin monoresistance, and 81 with multidrug resistance. The specificity of the FluoroType MTBDR was 100% (95% confidence interval [CI], 96.0 to 100%) for both rifampin and isoniazid. The sensitivity was 91.7% (95% CI, 83.6 to 96.6%) for isoniazid and 98.9% (95% CI, 93.8 to 100.0%) for rifampin. The FluoroType MTBDR has a high sensitivity and specificity for the detection of rifampin and isoniazid resistance when using culture isolates

DeWitt Wallace Library Annual Report 2015-2016

Summary of library and media services activities for 2015-201

Wellbeing in adults who had a brush with death

Objectives: A Near-Death-Experience can be a lifechanging event initiating deep posttraumatic growth. Yet people can initially be left struggling with the internal changes and feel alienated from their life and social network. This study investigated whether Near-Death-Experiences also have an impact on people’s happiness, and if so, how long it lasts, and what kind of support they receive in making sense of the event. Method: Six semi-structured interviews were conducted with people who had a Near-Death-Experience and the data was subjected to Interpretative Phenomenological Analysis. Results: Five master-themes emerged: Sense of self, Attitude toward life and death, Effects of Near-Death-Experience, Relationship with others, and Experience of happiness. Conclusion: Almost all participants reported feeling less apprehensive towards death and simultaneously found a greater ability to embrace and appreciate life. Some gained new and profound internal insights that manifested in a renewed sense of self, stronger and more pronounced feelings of life purpose, and could reflect on the Near-Death-Experience as a precious gift. The majority of participants experienced a greater degree of happiness that gradually grew over time. This was largely located internally, which freed them from ‘the hedonic treadmill’ of pursuing it in the outside world. Stigma and a lack of awareness still represent a hurdle for connecting with others and accessing support. Clinical and research implications were discussed

New and Improved Diagnostics for Detection of Drug-Resistant Pulmonary Tuberculosis.

PURPOSE OF REVIEW: Tuberculosis (TB) remains a global emergency and continues to kill 1.7 million people globally each year. Drug-resistant TB is now well established throughout the world and most TB patients are not being screened for drug resistance due to lack of laboratory resources and rapid accurate point-of-care tests. Accurate and rapid diagnosis of TB and drug-resistant TB is of paramount importance in establishing appropriate clinical management and infection control measures. During the past decade, there have been significant advances in diagnostic technologies for TB and drug-resistant TB. The purpose of this article is to review the current data, recommendations and evidence base for these tests. RECENT FINDINGS: Second-line drug susceptibility testing (DST) is complex and expensive. Automated liquid culture systems and molecular line probe assays are recommended by the WHO as the current 'gold standard' for first-line DST. Liquid culture DST for aminoglycosides, polypeptides and fluoroquinolones has been shown to have relatively good reliability and reproducibility for diagnosis of extensively drug-resistant TB; however, DST for other second-line drugs (ethionamide, prothionamide, cycloserine, terizidone, para-aminosalicylic acid, clofazimine, amoxicillin-clavulanate, clarithromycin, linezolid) is not recommended. Automated liquid culture systems are currently recommended by the WHO as the 'gold standard' for second-line DST. SUMMARY: In this review, we describe the phenotypic and genotypic methods currently available for the diagnosis of TB and drug-resistant forms of Mycobacterium tuberculosis and discuss future prospects for TB diagnostics. Current technologies for the detection of drug resistant M. tuberculosis vary greatly in terms of turnaround time, cost and complexity. Ultimately, the 'holy grail' diagnostic for TB must fulfil all technical specifications for a good point-of-care test, screen for drug resistance concurrently and be adaptable to the various health system levels and to countries with diverse economic status and TB burden. © 2011 Lippincott Williams & Wilkins, Inc

The Birth of Greece out of the Spirit of Music: The Romantic Folk Song Discourse and its Significance for German Philhellenism

Die vorliegende Studie beleuchtet die deutsche Rezeption der neugriechischen Volkslieder und ihre Bedeutung für den Philhellenismus des frühen 19. Jahrhunderts. Ausgehend von den Volksliedprojekten Johann Gottfried Herders und der deutschen Romantiker wird gezeigt, wie der zeitgenössische Volkslieddiskurs einerseits dazu beiträgt, die Griechen als prototypisches Naturvolk zu imaginieren, andererseits auf der Grundlage dieser „Natur- und Nationalpoesie“ einen historischen Zusammenhang zwischen dem modernen Griechenland und seinem antiken Kulturerbe zu konstruieren. Die Herausbildung des philhellenischen Volkslieddiskurses wird hier am Beispiel der neugriechischen Volksliedsammlung Werner von Haxthausens untersucht, deren Entstehungsgeschichte sich im Übergang vom romantischen Volksliedinteresse zum politischen Engagement von 1821 bewegt.This study sheds light on the German reception of modern Greek folk songs and their significance for the philhellenism of the early 19th century. Based on the folk song projects of Johann Gottfried Herder and the German Romantics, it shows how the contemporary folk song discourse contributed to imagining the Greeks as prototype of the natural human being and, on the other hand, to constructing a historical connection between modern Greece and its ancient cultural heritage based upon this “nature and national poetry”. The development of the philhellenic folk song discourse is examined here using the example of Werner von Haxthausen’s collection of modern Greek folk songs, created in the transitional phase from the romantic interest in folk songs to the political movement of 1821

Evaluation of Xpert® MTB/RIF and ustar easyNAT™ TB IAD for diagnosis of tuberculous lymphadenitis of children in Tanzania : a prospective descriptive study

Fine needle aspiration biopsy has become a standard approach for diagnosis of peripheral tuberculous lymphadenitis. The aim of this study was to compare the performance of Xpert MTB/RIF and Ustar EasyNAT TB IAD nucleic acid amplification assays, against acid-fast bacilli microscopy, cytology and mycobacterial culture for the diagnosis of TB lymphadenitis in children from a TB-endemic setting in Tanzania.; Children of 8 weeks to 16 years of age, suspected of having TB lymphadenitis, were recruited at a district hospital in Tanzania. Fine needle aspirates of lymph nodes were analysed using acid-fast bacilli microscopy, liquid TB culture, cytology, Xpert MTB/RIF and EasyNAT. Latent class analysis and comparison against a composite reference standard comprising "culture and/or cytology" was done, to assess the performance of Xpert MTB/RIF and EasyNAT for the diagnosis of TB lymphadenitis.; Seventy-nine children were recruited; 4 were excluded from analysis. Against a composite reference standard of culture and/or cytology, Xpert MTB/RIF and EasyNAT had a sensitivity and specificity of 58 % and 93 %; and 19 % and 100 % respectively. Relative to latent class definitions, cytology had a sensitivity of 100 % and specificity of 94.7 %.; Combining clinical assessment, cytology and Xpert MTB/RIF may allow for a rapid and accurate diagnosis of childhood TB lymphadenitis. Larger diagnostic evaluation studies are recommended to validate these findings and on Xpert MTB/RIF to assess its use as a solitary initial test for TB lymphadenitis in children