Decline in Telomere Length by Age and Effect Modification by Gender, Allostatic Load and Comorbidities in National Health and Nutrition Examination Survey (1999-2002)

Background: This study aims to assess the decline in telomere length (TL) with age and evaluate effect modification by gender, chronic stress, and comorbidity in a representative sample of the US population. Methods: Cross-sectional data on 7826 adults with a TL measurement, were included from the National Health and Nutrition Examination Survey, years 1999–2002. The population rate of decline in TL across 10-year age categories was estimated using crude and adjusted regression. Results: In an adjusted model, the population rate of decline in TL with age was consistent and linear for only three age categories: 20–29 (β = -0.0172, 95% CI: -0.0342, -0.0002), 50–59 (β = -0.0182, 95% CI: -0.0311, -0.0054) and 70–79 (β = -0.0170, 95% CI: -0.0329, -0.0011) years. The population rate of decline in TL with age was significantly greater for males and those with high allostatic load and a history of comorbidities. When the population rate of decline in TL was analyzed by gender in 10-year age bins, a fairly consistent yet statistically non-significant decline for males was observed; however, a trough in the rate was observed for females in the age categories 20–29 years (β = -0.0284, 95% CI: -0.0464, -0.0103) and 50–59 years (β = -0.0211, 95% CI: -0.0391, -0.0032). To further elucidate the gender difference observed in the primary analyses, secondary analyses were conducted with reproductive and hormonal status; a significant inverse association was found between TL and parity, menopause, and age at menopause. Conclusions: TL was shorter with increasing age and this decline was modified by gender, chronic stress and comorbidities; individuals with chronic morbidity and/or chronic stress and females in their twenties and fifties experienced greater decline. Female reproductive factors, i.e., parity and menopause, were associated with TL

Tributes to Professor Robert Berkley Harper

In 1977, I began teaching at The University of Pittsburgh Law School and in short order one of my closest friends during my tenure there was Professor Robert “Bob” Harper. I wondered when I was hired whether I was selected because I looked strikingly similar to Bob, and perhaps the faculty thought my favoring Professor Harper would make my assimilation into the law school faculty that much easier. Students constantly called me Professor Harper and, indeed, many on the faculty called me Bob for several years; I never bothered to correct them. I thought if they paid that little attention to detail in law school, I would just let them go through life missing some of the finer points their education, and life for that matter, has to offer

"Nothing new": responses to the introduction of antiretroviral drugs in South Africa.

Interviews conducted in South Africa found that awareness of antiretroviral therapy was generally poor. Antiretroviral drugs were not perceived as new, but one of many alternative therapies for HIV/AIDS. Respondents had more detailed knowledge of indications, effects and how to access alternative treatments, which is bolstered by the active promotion and legitimization of alternative treatments. Many expressed a lack of excitement about the introduction of antiretroviral therapy, and little change in their attitudes concerning the epidemic

Joint Responsibility for the Operationof the Enterprise: Workplace Reform at BHP New Zealand

Ryan's (1994 )framework for understanding the essential components of workplace reform ties management notions of quality and continuous improvement- key 'drivers' in New Zealand business today- to union concerns about shared decision-making and joint responsibility between management and labour. The purpose of the present paper is to use a 'grounded theory' approach to further develop and illustrate that framework, drawing on a recent case study of workplace reform at BHP New Zealand Steel's Glenbrook plant between 1990 and 1994. Case study data on the company's Business Improvement Programme (BIP) shows what 'joint responsibility' actually means in terms of the development of business strategy and work practices built round quality on a day-to-day basis

Effects of Fermion Localization in Higgsless Theories and Electroweak Constraints

Extra-dimensional Higgsless models with electroweak symmetry breaking through boundary conditions generically have difficulties with electroweak precision constraints, when the fermions are localized to the ``branes'' in the fifth dimension. In this paper we show that these constraints can be relaxed by allowing the light fermions to have a finite extent into the bulk of the fifth dimension. The $T$ and $U$ electroweak parameters can be naturally suppressed by a custodial symmetry, while the $S$ parameter can be made to vanish through a cancellation, if the leakage into the bulk of the light gauge fields and the light left-handed fermion fields are of the same size. This cancellation is possible while allowing realistic values for the first two generations of fermion masses, although special treatment is probably required for the top quark. We present this idea here in the context of a specific continuum theory-space model; however, it can be applied to any five-dimensional Higgsless model, either with a flat or a warped background.Comment: 10 pages, JHEP format, comments and reference to related paper adde

Impact of boundaries on fully connected random geometric networks

Many complex networks exhibit a percolation transition involving a macroscopic connected component, with universal features largely independent of the microscopic model and the macroscopic domain geometry. In contrast, we show that the transition to full connectivity is strongly influenced by details of the boundary, but observe an alternative form of universality. Our approach correctly distinguishes connectivity properties of networks in domains with equal bulk contributions. It also facilitates system design to promote or avoid full connectivity for diverse geometries in arbitrary dimension.Comment: 6 pages, 3 figure

Detection of an endangered mammalian species using environmental DNA analysis

Poster presented at The Mammal Society 63rd Spring Conference & AGM, 31st March-2nd April, 2017, Cambridge, UK