Social research for a multiethnic population: do the research ethics and standards guidelines of UK Learned Societies address this challenge?

There is increasing recognition in the UK that social science research should generate an evidence base that reflects the ethnic diversity of the population and informs positive developments in public policy and programmes for all. However, describing and understanding ethnic diversity, and associated disadvantage, is far from straightforward. In practice, the ethical and scientific arguments around whether and how to incorporate ethnicity into policy-relevant social research are complex and contentious. In particular, untheorised or insensitive inclusion of data on ethnic 'groups' can have negative consequences. The present investigation begins to explore the extent to which social scientists have access to advice and guidance in this area of research. Specifically, the paper examines how ethnic diversity is explicitly or implicitly considered within the research ethics and scientific standard guidance provided by UK social science Learned Societies to their members. The review found little in the way of explicit attention to ethnic diversity in the guidance documents, but nevertheless identified a number of pertinent themes. The paper compiles and extrapolates these themes to present a tentative set of principles for social scientists to debate and further develop

Viral delivery of antioxidant genes as a therapeutic strategy in experimental models of amyotrophic lateral sclerosis.

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder with no effective treatment to date. Despite its multi-factorial aetiology, oxidative stress is hypothesized to be one of the key pathogenic mechanisms. It is thus proposed that manipulation of the expression of antioxidant genes that are downregulated in the presence of mutant SOD1 may serve as a therapeutic strategy for motor neuronal protection. Lentiviral vectors expressing either PRDX3 or NRF2 genes were tested in the motor neuronal-like NSC34 cell line, and in the ALS tissue culture model, NSC34 cells expressing the human SOD1(G93A) mutation. The NSC34 SOD1(G93A) cells overexpressing either PRDX3 or NRF2 showed a significant decrease in endogenous oxidation stress levels by 40 and 50% respectively compared with controls, whereas cell survival was increased by 30% in both cases. The neuroprotective potential of those two genes was further investigated in vivo in the SOD1(G93A) ALS mouse model, by administering intramuscular injections of adenoassociated virus serotype 6 (AAV6) expressing either of the target genes at a presymptomatic stage. Despite the absence of a significant effect in survival, disease onset or progression, which can be explained by the inefficient viral delivery, the promising in vitro data suggest that a more widespread CNS delivery is needed

The reverberation signatures of rotating disc winds in active galactic nuclei

The broad emission lines (BELs) in active galactic nuclei (AGN) respond to ionizing continuum variations. The time and velocity dependence of their response depends on the structure of the broad-line region: its geometry, kinematics and ionization state. Here, we predict the reverberation signatures of BELs formed in rotating accretion disc winds. We use a Monte Carlo radiative transfer and ionization code to predict velocity-delay maps for representative high- (C$~IV$) and low-ionization (H$\alpha$) emission lines in both high- and moderate-luminosity AGN. Self-shielding, multiple scattering and the ionization structure of the outflows are all self-consistently taken into account, while small-scale structure in the outflow is modelled in the micro-clumping approximation. Our main findings are: (1) The velocity-delay maps of smooth/micro-clumped outflows often contain significant negative responses. (2)~The reverberation signatures of disc wind models tend to be rotation dominated and can even resemble the classic "red-leads-blue" inflow signature. (3) Traditional "blue-leads-red" outflow signatures can usually only be observed in the long-delay limit. (4) Our models predict lag-luminosity relationships similar to those inferred from observations, but systematically underpredict the observed centroid delays. (5) The ratio between "virial product" and black hole mass predicted by our models depends on viewing angle. Our results imply that considerable care needs to be taken in interpreting data obtained by observational reverberation mapping campaigns. In particular, basic signatures such as "red-leads-blue", "blue-leads-red" and "blue and red vary jointly" are not always reliable indicators of inflow, outflow or rotation. This may help to explain the perplexing diversity of such signatures seen in observational campaigns to date.Comment: 15 pages, 17 figures, 2 tables. Accepted by MNRAS 20/7/201

Woody vegetation cover monitoring with multi-temporal Landsat data and Random Forests: the case of the Northwest Province (South Africa)

Land degradation and desertification (LDD) are serious global threats to humans and the environment. Globally, 10-20% of drylands and 24% of the world’s productive lands are potentially degraded, which affects 1.5 billion people and reduces GDP by €3.4 billion. In Africa, LDD processes affect up to a third of savannahs, leading to a decline in the ecosystem services provided to some of the continent’s poorest and most vulnerable communities. Indirectly, LDD can be monitored using relevant indicators. The encroachment of woody plants into grasslands, and the subsequent conversion of savannahs and open woodlands into shrublands, has attracted a lot of attention over the last decades and has been identified as an indicator of LDD. According to some assessments, bush encroachment has rendered 1.1 million ha of South African savanna unusable, threatens another 27 million ha (~17% of the country), and has reduced the grazing capacity throughout the region by up to 50%. Mapping woody cover encroachment over large areas can only be effectively achieved using remote sensing data and techniques. The longest continuously operating Earth-observation program, the Landsat series, is now freely-available as an atmospherically corrected, cloud masked surface reflectance product. The availability and length of the Landsat archive is thus an unparalleled Earth-observation resource, particularly for long-term change detection and monitoring. Here, we map and monitor woody vegetation cover in the Northwest Province of South Africa, a mosaic of 12 Landsat scenes that expands over more than 100,000km2. We employ a multi-temporal approach with dry-season TM, ETM+ and OLI data from 15 epochs between 1989 to 2015. We use 0.5m-pixel colour aerial photography to collect >15,000 samples for training and validating a Random Forest model to map woody cover, grasses, crops, urban and bare areas. High classification accuracies are achieved, especially so for the two cover types indirectly linked with bush encroachment, i.e. woody cover and grasses. Results show that there is a steady increase in woody vegetation cover over the 26-year-long period of study in the expense of graminoids. We identify woody vegetation encroachment ‘hot-spots’ where mitigation measures are required and thus provide a management tool for the prioritisation of such measures in degraded and food-insecure areas. Our approach can be instrumental in informing international land degradation mitigation and adaptation policy interventions that can advance sustainable development and protect livelihoods and lives in South Africa and other African savannahs

Experience of and access to maternity care in the UK by immigrant women: a narrative synthesis systematic review

© 2019 Author(s). One in four births in the UK is to foreign-born women. In 2016, the figure was 28.2%, the highest figure on record, with maternal and perinatal mortality also disproportionately higher for some immigrant women. Our objective was to examine issues of access and experience of maternity care by immigrant women based on a systematic review and narrative synthesis of empirical research. Review methods: A research librarian designed the search strategies (retrieving literature published from 1990 to end June 2017). We retrieved 45 954 citations and used a screening tool to identify relevance. We searched for grey literature reported in databases/websites. We contacted stakeholders with expertise to identify additional research. Results: We identified 40 studies for inclusion: 22 qualitative, 8 quantitative and 10 mixed methods. Immigrant women, particularly asylum-seekers, often booked and accessed antenatal care later than the recommended first 10 weeks. Primary factors included limited English language proficiency, lack of awareness of availability of the services, lack of understanding of the purpose of antenatal appointments, immigration status and income barriers. Maternity care experiences were both positive and negative. Women with positive perceptions described healthcare professionals as caring, confidential and openly communicative in meeting their medical, emotional, psychological and social needs. Those with negative views perceived health professionals as rude, discriminatory and insensitive to their cultural and social needs. These women therefore avoided continuously utilising maternity care. We found few interventions focused on improving maternity care, and the effectiveness of existing interventions have not been scientifically evaluated. Conclusions: The experiences of immigrant women in accessing and using maternity care services were both positive and negative. Further education and training of health professionals in meeting the challenges of a super-diverse population may enhance quality of care, and the perceptions and experiences of maternity care by immigrant women

Landsat-based woody vegetation cover monitoring in Southern African savannahs

Mapping woody cover over large areas can only be effectively achieved using remote sensing data and techniques. The longest continuously operating Earth-observation program, the Landsat series, is now freely-available as an atmospherically corrected, cloud masked surface reflectance product. The availability and length of the Landsat archive is thus an unparalleled Earth-observation resource, particularly for long-term change detection and monitoring. Here, we map and monitor woody vegetation cover in the Northwest Province of South Africa, an area of more than 100,000km2 covered by 11 Landsat scenes. We employ a multi-temporal approach with dry-season data from 7 epochs between 1990 to 2015. We use 0.5m-pixel colour aerial photography to collect >15,000 point samples for training and validating Random Forest classifications of (i) woody vegetation cover, (ii) other vegetation types (including grasses and agricultural land), and (iii) non-vegetated areas (i.e. urban areas and bare land). Overall accuracies for all years are around 80% and overall kappa between 0.45 and 0.66. Woody vegetation covers a quarter of the Province and is the most accurately mapped class (balanced accuracies between 0.74-0.84 for the 7 epochs). There is a steady increase in woody vegetation cover over the 25-year-long period of study in the expense of the other vegetation types. We identify potential woody vegetation encroachment 'hot-spots' where mitigation measures might be required and thus provide a management tool for the prioritisation of such measures in degraded and food-insecure areas

Electromagnetically induced transparency and four-wave mixing in a cold atomic ensemble with large optical depth

We report on the delay of optical pulses using electromagnetically induced transparency in an ensemble of cold atoms with an optical depth exceeding 500. To identify the regimes in which four-wave mixing impacts on EIT behaviour, we conduct the experiment in both rubidium 85 and rubidium 87. Comparison with theory shows excellent agreement in both isotopes. In rubidium 87, negligible four-wave mixing was observed and we obtained one pulse-width of delay with 50% efficiency. In rubidium 85, four-wave-mixing contributes to the output. In this regime we achieve a delay-bandwidth product of 3.7 at 50% efficiency, allowing temporally multimode delay, which we demonstrate by compressing two pulses into the memory medium.Comment: 8 pages, 6 figure