Nazım Hikmet'in vatan hainliği

Taha Toros Arşivi, Dosya Adı: Nazım Hikmet. Not: Gazetenin "Tersi Yüzü" köşesinde yayımlanmıştır.İstanbul Kalkınma Ajansı (TR10/14/YEN/0033) İstanbul Development Agency (TR10/14/YEN/0033

Performances of JEM-EUSO

In this paper we describe the requirements and the expected performances of JEM-EUSO. Designed as the first mission to explore the Ultra High Energy Universe from space, JEM-EUSO will monitor the earth's atmosphere at night to record the UV (300–400 nm) tracks generated by the Extensive Air Showers produced by Ultra High Energy primaries propagating in the atmosphere. After briefing summarizing the main aspects of the JEM-EUSO Instrument and mission baseline, we will present, in details, our studies of the expected trigger rate, the estimated exposure, as well as on the expected angular, energy, and Xmax resolution. Eventually, the obtained results will be discussed in the context of the scientific requirements of the mission

Diversity of SCCmec Elements in Methicillin-Resistant Coagulase-Negative Staphylococci Clinical Isolates

in MR-CoNS can generate useful information on the mobilization and evolution of this element.). in MR-CoNS

The Opdc missense mutation of Pax2 has a milder than loss-of-function phenotype

Renal-coloboma syndrome, also known as papillorenal syndrome, is an autosomal dominant human disorder in which optic disc coloboma is associated with kidney abnormalities. Mutations in the paired domain transcription factor PAX2 have been found to be the underlying cause of this disease. Disease severity varies between patients, and in some cases, renal hypoplasia has been found in the absence of any retinal defects. Here we report an N-ethyl-N-nitrosourea-induced mouse mutation, Opdc, which is an isoleucinetothreonine missense mutation, I40T, in the first α-helix of the Pax2 paired domain. The mutant protein binds target DNA sequences less strongly than the wild-type protein and acts poorly to transactivate target promoters in culture. The phenotypic consequence of this mutation on the development of the eye and ear is similar to that reported for null alleles of Pax2. However, in homozygotes, cerebellar development is normal on a genetic background in which loss of Pax2 results in failure of cerebellar formation. Moreover, there is a genetic background effect on the heterozygous phenotype such that on some strain backgrounds, kidney development is unaffected. Opdc is the first hypomorphic mutation reported for Pax2 that differs in phenotype from loss-of-function mutations. These results suggest that PAX2 is a strong candidate gene for cases in which human patients have optic disc coloboma not associated with renal dysplasia

Performances of JEM-EUSO

In this paper we describe the requirements and the expected performances of JEM-EUSO. Designed as the first mission to explore the Ultra High Energy Universe from space, JEM-EUSO will monitor the earth's atmosphere at night to record the UV (300–400 nm) tracks generated by the Extensive Air Showers produced by Ultra High Energy primaries propagating in the atmosphere. After briefing summarizing the main aspects of the JEM-EUSO Instrument and mission baseline, we will present, in details, our studies of the expected trigger rate, the estimated exposure, as well as on the expected angular, energy, and Xmax resolution. Eventually, the obtained results will be discussed in the context of the scientific requirements of the mission

A Novel Gene, fudoh, in the SCCmec Region Suppresses the Colony Spreading Ability and Virulence of Staphylococcus aureus

Staphylococcus aureus colonies can spread on soft agar plates. We compared colony spreading of clinically isolated methicillin-sensitive S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA). All MSSA strains showed colony spreading, but most MRSA strains (73%) carrying SCCmec type-II showed little colony spreading. Deletion of the entire SCCmec type-II region from these MRSA strains restored colony spreading. Introduction of a novel gene, fudoh, carried by SCCmec type-II into Newman strain suppressed colony spreading. MRSA strains with high spreading ability (27%) had no fudoh or a point-mutated fudoh that did not suppress colony spreading. The fudoh-transformed Newman strain had decreased exotoxin production and attenuated virulence in mice. Most community-acquired MRSA strains carried SCCmec type-IV, which does not include fudoh, and showed high colony spreading ability. These findings suggest that fudoh in the SCCmec type-II region suppresses colony spreading and exotoxin production, and is involved in S. aureus pathogenesis