HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning.

White adipose tissue (WAT) can undergo a phenotypic switch, known as browning, in response to environmental stimuli such as cold. Post-translational modifications of histones have been shown to regulate cellular energy metabolism, but their role in white adipose tissue physiology remains incompletely understood. Here we show that histone deacetylase 3 (HDAC3) regulates WAT metabolism and function. Selective ablation of Hdac3 in fat switches the metabolic signature of WAT by activating a futile cycle of de novo fatty acid synthesis and β-oxidation that potentiates WAT oxidative capacity and ultimately supports browning. Specific ablation of Hdac3 in adipose tissue increases acetylation of enhancers in Pparg and Ucp1 genes, and of putative regulatory regions of the Ppara gene. Our results unveil HDAC3 as a regulator of WAT physiology, which acts as a molecular brake that inhibits fatty acid metabolism and WAT browning.Histone deacetylases, such as HDAC3, have been shown to alter cellular metabolism in various tissues. Here the authors show that HDAC3 regulates WAT metabolism by activating a futile cycle of fatty acid synthesis and oxidation, which supports WAT browning

Imaging the dephasing of spin wave modes in a square thin film magnetic element

Copyright © 2004 The American Physical SocietyWe have used time-resolved scanning Kerr effect microscopy to study dephasing of spin wave modes in a square Ni81Fe19 element of 10 μm width and 150 nm thickness. When a static magnetic field H was applied parallel to an edge of the square, demagnetized regions appeared at the edges orthogonal to the field. When H was applied along a diagonal, a demagnetized region appeared along the opposite diagonal. Time-resolved images of the out-of-plane magnetization component showed stripes that lie perpendicular to H and indicate the presence of spin wave modes with wave vector parallel to the static magnetization. The transient Kerr rotation was measured at different positions along an axis parallel to H, and the power spectra revealed a number of different modes. Micromagnetic simulations reproduce both the observed images and the mode frequencies. This study allows us to understand an anisotropic damping observed at the center of the square element in terms of dephasing of the resonant mode spectrum

Measurement of the Spin Correlation Parameters all and Asl for the Reaction Pp-]D-Pi+ in the Energy Region 500-800 Mev

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Time Marches on, and So Does the History of Public Relations

Editor's Introduction to History of Public Relations special issu

Measurement of the H-1(d-],N-])Pp Transverse Polarization Transfer-Coefficient at 42.8 Mev

Journals published by the American Physical Society can be found at http://publish.aps.org

K+ Total Cross-Sections on C-12 and Medium Effects in Nuclei

Journals published by the American Physical Society can be found at http://publish.aps.org/The total cross sections for K+ mesons on carbon and deuterium nuclei have been measured at eleven momenta in the range 450-740 MeV/c. The experimental technique was of the standard transmission type. The K+ meson is the least strongly interacting of available hadronic probes, with a long mean free path in nuclear matter. At low incident momentum the K+ N interaction is dominated by the S11 phase shift and varies slowly with energy. These characteristics make the K+ an ideal tool for probing the nuclear volume to reveal nuclear medium effects. Measurements of the ratio of the total cross sections, per nucleon, of K+-C-12 to K+-d have been suggested as a way to reveal effects of the nuclear medium. The total cross section ratios are found to lie significantly above those predicted by the usual nuclear medium corrections. This suggests that novel phenomena axe taking place within the nucleus. Several models which incorporate such phenomena are discussed, including nucleon "swelling," mass rescaling, nuclear pions, and relativistic effects

Early numerical competencies in 5- and 6-year-old children with autism spectrum disorder

Research Findings: To date, studies comparing the mathematical abilities of children with autism spectrum disorder (ASD) and typically developing children are scarce, and results remain inconclusive. In general, studies on this topic focus on mathematical abilities learned from elementary school onward, with little attention for possible precursors at younger ages. The current exploratory study focused on the important developmental period of preschool age, investigating 5 early numerical competencies in 30 high-functioning children with ASD and 30 age-matched control children: verbal subitizing, counting, magnitude comparison, estimation, and arithmetic operations. Children were examined at 5 or 6 years of age, attending the 3rd and final year of preschool. Overall, rather similar early number processing was found in children with and without ASD, although marginally significant results indicated a weaker performance of children with ASD on verbal subitizing and conceptual counting. Practice or Policy: Given the pervasiveness and impact of ASD on other domains of functioning, it is important to know that no general deficits in early numerical competencies were found in this study. However, some downward trends in mathematics performance were identified in children with ASD, which can serve as the basis for additional research in this field

Zero-Crossing Angle in the Np Analyzing Power at Medium Energies and its Relation to Charge Symmetry

Journals published by the American Physical Society can be found at http://publish.aps.org