In Vivo Application of Proton-Electron Double-Resonance Imaging

This work was partially supported by NIH grants 1ZIABC010477-14 (MKC), CA194013 (VVK), CA192064 (VVK), U54GM104942 (VVK); by KAKENHI grant 16H05113 (H.U.) from the Japan Society for the Promotion of Science (HU) and start-up grant from the WVCTSI (VVK).Peer reviewedPostprin

Electronic correlation strength of inorganic electrides from first principles

Strongly correlated electron systems, generally recognized as d- and f-electron systems, have attracted attention as a platform for the emergence of exotic properties such as high-Tc superconductivity. However, correlated electron behaviors have been recently observed in a group of novel materials, electrides, in which s-electrons are confined in subnanometer-sized spaces. Here, we present a trend of electronic correlation of electrides by evaluating the electronic correlation strength obtained from model parameters characterizing effective Hamiltonians of 19 electrides from first principles. The calculated strengths vary in the order 0D ≫ 1D > 2D ∼ 3D electrides, which corresponds to experimental trends, and exceed 10 (a measure for the emergence of exotic properties) in all of the 0D and some of the 1D electrides. We also found the electronic correlation depends on the cation species surrounding the s-electrons. The results indicate that low-dimensional electrides will be new research targets for studies of strongly correlated electron systems

Pharmacist-physician collaborative care for outpatients with left ventricular assist devices using a cloud-based home medical management information-sharing system: a case report

[Background] The standard anticoagulation therapy for patients implanted with left ventricular assist devices (LVADs) includes warfarin therapy. We developed a cloud-based home medical management information-sharing system named as LVAD@home. The LVAD@home system is an application designed to be used on iPad tablet computers. This system enables the sharing of daily information between a patient and care providers in real time. In this study, we reported cases of outpatients with LVADs using this system to manage anticoagulation therapy. [Case presentation] The patient, a man in his 40s with end-stage heart failure owing to non-ischemic dilated cardiomyopathy, underwent LVAD implantation and warfarin was started on postoperative day 1. He started to use LVAD@home to manage warfarin therapy after discharge (postoperative day 47). He sent his data to care providers daily. By using this system, the pharmacist observed his signs of reduced dietary intake 179 days after discharge, and after consulting the physician, told the patient to change the timing of the next measurement earlier than usual. On the next day, the prothrombin time-international normalized ratio increased from 2.0 to 3.0, and thus the dose was decreased by 0.5 mg. Four patients used this system to monitor warfarin therapy from October 2015 to March 2018. In these patients, the time in therapeutic range was 90.1 ± 1.3, which was higher than that observed in previous studies. Additionally, there were no thromboembolic events or bleeding events. [Conclusions] The cloud-based home management system can be applied to share real-time patient information of factors, including dietary intake that interact with warfarin. It can help to improve long-term anticoagulation outcomes in patients implanted with LVAD

Hyper-luminous Dust Obscured Galaxies discovered by the Hyper Suprime-Cam on Subaru and WISE

We present the photometric properties of a sample of infrared (IR) bright dust obscured galaxies (DOGs). Combining wide and deep optical images obtained with the Hyper Suprime-Cam (HSC) on the Subaru Telescope and all-sky mid-IR (MIR) images taken with Wide-Field Infrared Survey Explorer (WISE), we discovered 48 DOGs with $i - K_\mathrm{s} > 1.2$ and $i - [22] > 7.0$, where $i$, $K_\mathrm{s}$, and [22] represent AB magnitude in the $i$-band, $K_\mathrm{s}$-band, and 22 $\mu$m, respectively, in the GAMA 14hr field ($\sim$ 9 deg$^2$). Among these objects, 31 ($\sim$ 65 %) show power-law spectral energy distributions (SEDs) in the near-IR (NIR) and MIR regime, while the remainder show a NIR bump in their SEDs. Assuming that the redshift distribution for our DOGs sample is Gaussian, with mean and sigma $z$ = 1.99 $\pm$ 0.45, we calculated their total IR luminosity using an empirical relation between 22 $\mu$m luminosity and total IR luminosity. The average value of the total IR luminosity is (3.5 $\pm$ 1.1) $\times$ $10^{13}$ L$_{\odot}$, which classifies them as hyper-luminous infrared galaxies (HyLIRGs). We also derived the total IR luminosity function (LF) and IR luminosity density (LD) for a flux-limited subsample of 18 DOGs with 22 $\mu$m flux greater than 3.0 mJy and with $i$-band magnitude brighter than 24 AB magnitude. The derived space density for this subsample is log $\phi$ = -6.59 $\pm$ 0.11 [Mpc$^{-3}$]. The IR LF for DOGs including data obtained from the literature is well fitted by a double-power law. The derived lower limit for the IR LD for our sample is $\rho_{\mathrm{IR}}$ $\sim$ 3.8 $\times$ 10$^7$ [L$_{\odot}$ Mpc$^{-3}$] and its contributions to the total IR LD, IR LD of all ultra-luminous infrared galaxies (ULIRGs), and that of all DOGs are $>$ 3 %, $>$ 9 %, and $>$ 15 %, respectively.Comment: 15 pages, 15 figures, and 3 tables, accepted for publication in PASJ (Subaru special issue

Hyper Suprime-Camera Survey of the Akari NEP Wide Field

The extragalactic background suggests half the energy generated by stars was reprocessed into the infrared (IR) by dust. At z ∼1.3, 90% of star formation is obscured by dust. To fully understand the cosmic star formation history, it is critical to investigate infrared emission. AKARI has made deep mid-IR observation using its continuous 9-band filters in the NEP field (5.4 deg2), using ∼10% of the entire pointed observations available throughout its lifetime. However, there remain 11,000 AKARI infrared sources undetected with the previous CFHT/Megacam imaging (r ∼25.9ABmag). Redshift and IR luminosity of these sources are unknown. These sources may contribute significantly to the cosmic star-formation rate density (CSFRD). For example, if they all lie at 1 z g, r, i, z, and y) using Hyper Suprime-Camera (HSC), which has 1.5 deg field of view in diameter on Subaru 8m telescope. This will provide photometric redshift information, and thereby IR luminosity for the previously-undetected 11,000 faint AKARI IR sources. Combined with AKARI's mid-IR AGN/SF diagnosis, and accurate mid-IR luminosity measurement, this will allow a complete census of cosmic star-formation/AGN accretion history obscured by dust

Event-to-event intensification of the hydrologic cycle from 1.5 °C to a 2 °C warmer world

Abstract The Paris agreement was adopted to hold the global average temperature increase to well below 2 °C and pursue efforts to limit it to 1.5 °C. Here, we investigate the event-to-event hydroclimatic intensity, where an event is a pair of adjacent wet and dry spells, under future warming scenarios. According to a set of targeted multi-model large ensemble experiments, event-wise intensification will significantly increase globally for an additional 0.5 °C warming beyond 1.5 °C. In high latitudinal regions of the North American continent and Eurasia, this intensification is likely to involve overwhelming increases in wet spell intensity. Western and Eastern North America will likely experience more intense wet spells with negligible changes of dry spells. For the Mediterranean region, enhancement of dry spells seems to be dominating compared to the decrease in wet spell strength, and this will lead to an overall event-wise intensification. Furthermore, the extreme intensification could be 10 times stronger than the mean intensification. The high damage potential of such drastic changes between flood and drought conditions poses a major challenge to adaptation, and the findings suggest that risks could be substantially reduced by achieving a 1.5 °C target

Infrared luminosity functions based on 18 mid-infrared bands: revealing cosmic star formation history with AKARI and Hyper Suprime-Cam*

Much of star formation is obscured by dust. For a complete understanding of the cosmic star formation history (CSFH), infrared (IR) census is indispensable. AKARI carried out deep mid-infrared observations using its continuous nine-band filters in the North Ecliptic Pole (NEP) field (5.4 deg2). This took a significant amount of the satellite’s lifetime, ∼10% of the entire pointed observations. By combining archival Spitzer (five bands) and WISE (four bands) mid-IR photometry, we have, in total, 18-band mid-IR photometry, which is the most comprehensive photometric coverage in the mid-IR for thousands of galaxies. However, we only had shallow optical imaging (∼25.9 AB magnitude) in a small area, 1.0 deg2. As a result, thousands of AKARI’s infrared sources remained undetected in the optical. Using the new Hyper Suprime-Cam on the Subaru telescope, we obtained deep enough optical images of the entire AKARI NEP field in five broad bands (g ∼ 27.5 mag). These provided photometric redshift, and thereby IR luminosity, for the previously undetected faint AKARI IR sources. Combined with the accurate mid-IR luminosity measurement, we constructed mid-IR luminosity functions (LFs), and thereby performed a census of dust-obscured CSFH in the entire AKARI NEP field. We have measured restframe 8 μm and 12 μm LFs, and estimated total infrared LFs at 0.35 z z ∼ 2

Search for Optically Dark Infrared Galaxies without Counterparts of Subaru Hyper Suprime-Cam in the AKARI North Ecliptic Pole Wide Survey Field

We present the physical properties of AKARI sources without optical counterparts in optical images from the Hyper Suprime-Cam (HSC) on the Subaru telescope. Using the AKARI infrared (IR) source catalog and HSC optical catalog, we select 583 objects that do not have HSC counterparts in the AKARI North Ecliptic Pole wide survey field (~5 deg2). Because the HSC limiting magnitude is deep (gAB ~ 28.6), these are good candidates for extremely red star-forming galaxies (SFGs) and/or active galactic nuclei (AGNs), possibly at high redshifts. We compile multiwavelength data out to 500 μm and use them for fitting the spectral energy distribution with CIGALE to investigate the physical properties of AKARI galaxies without optical counterparts. We also compare their physical quantities with AKARI mid-IR selected galaxies with HSC counterparts. The estimated redshifts of AKARI objects without HSC counterparts range up to z ~ 4, significantly higher than for AKARI objects with HSC counterparts. We find that (i) 3.6 – 4.5 μm color, (ii) AGN luminosity, (iii) stellar mass, (iv) star formation rate, and (v) V-band dust attenuation in the interstellar medium of AKARI objects without HSC counterparts are systematically larger than those of AKARI objects with counterparts. These results suggest that our sample includes luminous, heavily dust-obscured SFGs/AGNs at z ~ 1–4 that are missed by previous optical surveys, providing very interesting targets for the coming era of the James Webb Space Telescope