La operatividad turística de los espacios culturales de origen industrial. Una valoración de los grupos de interés a través del método Delphi

En el municipio de Madrid existen espacios culturales ubicados en antiguas instalaciones industriales que, tras el cese de sus actividades productivas, han experimentado procesos de transformación especialmente a lo que a usos se refiere. Estos contenedores culturales han sido acogidos de forma positiva por la población local y han incrementado considerablemente la oferta cultural de la ciudad. A pesar del éxito cultural de estos antiguos espacios industriales, su operatividad como recursos turísticos resulta incomprensiblemente baja. A través de esta investigación, estructurada mediante el método Delphi, se han detectado cuáles son los factores más relevantes que, según el panel de expertos seleccionado, limita la funcionalidad turística de estos espacios

Patterns of spatial changes on demersal species in the Gulf of Cadiz and northern Alboran Sea

The Gulf of Cadiz (GoC) in the Atlantic Ocean and the northern Alboran Sea (AS) in the Mediterranean Sea are part of an extremely important oceanographic complex in terms of water exchange between the Atlantic and the Mediterranean through the Strait of Gibraltar. Besides its significant role as an ecological transition system, it is unknown whether regional and local envi ronmental drivers affect similarly species inhabiting these two adjacent and connected ecosystems. This study analyses the spatial shifts of representative demersal species and their response to the environmental and demographic drivers in these two regions, using information from two trawl surveys carried out in the GoC and in the AS from 1994 to 2015. Species distribution trends were observed in both basins. However, they were more evident in the GoC, where six out of eleven species presented temporal trends, than in the AS, where only two species displayed significant distribution changes. In both basins, these species showed geographic displacements towards the Strait of Gibraltar. Also, a high percentage of species presented significant differences in mean depth distribution on the two sides of the Strait of Gibraltar. Our study shows a general heterogeneity and independence in the drivers influencing species distributions in the two areas. GoC was highly influenced by both large- and regional-scale climate factors, which affected several species, while in AS the diversity of drivers was greater, with species density being the most common. This study provides a scientific basis for improving ecosystem-based management measures in these important transitional ecosystems.Postprint0,56

Structural Brain Alterations in Female Survivors of Intimate Partner Violence

Intimate partner violence (IPV) has been related to brain alterations in female survivors. Nonetheless, few studies have used an exploratory approach, focusing on brain regions that are traditionally studied in other populations with post-traumatic stress. Traumatic brain injury (TBI), strangulation, and childhood trauma are highly prevalent among this population, and have also been associated with brain alterations and functional deterioration. As such, it is difficult to determine how different brain regions are affected by the complex interplay of these factors in female survivors. The aim of this study is to assess (a) brain alterations in female survivors of IPV as compared to non-victim females and (b) the potential causal mechanisms associated with such alterations. We hypothesized that structural brain differences would be found between female survivors of IPV and non-victims, and that these differences would be related to IPV-related TBI, strangulation, IPV severity, depression, post-traumatic stress, generalized anxiety, and childhood adverse experiences. A total of 27 non-victims and 28 survivors completed structural magnetic resonance imaging and questionnaires to measure the potential causal mechanisms for brain alterations. Structural brain differences were found between groups, principally in volumetric analyses. The brain regions in which between-group differences were found were related to attempted strangulation, IPV-related TBI, severity of IPV, adverse childhood experiences, and post-traumatic stress. These results demonstrate that a wider range of brain regions may be impacted by IPV and that various factors are implicated in the structural brain alterations found in female survivors. This study demonstrates the importance of post-traumatic stress, childhood and adult trauma, and physical violence in assessing brain alterations in IPV survivors. Further, it serves as a critical first step in assessing an extensive list of potential causal mechanisms for structural brain alterations, using a more comprehensive a whole-brain structural analysis of IPV female victims, a largely understudied and vulnerable population.I+D+I Operative Program FEDER project of the Andalusian Government in 2018 B-CTS-493-UGR18Ministry of Education and Professional Training in SpainUniversity of Granada (Spain)Spanish Ministry of Science, Innovation and Universities FJCI-2017-3339

Experimental investigation of geodesic acoustic modes on JET using Doppler backscattering

Geodesic acoustic modes (GAMs) have been investigated in JET ohmic discharges using mainly Doppler backscattering. Characteristics and scaling properties of the GAM are studied. Time and spatial resolved measurements of the perpendicular velocity indicate that GAMs are located in a narrow layer at the edge density gradient region with amplitude corresponding to about 50% of the mean local perpendicular velocity. GAMs on JET appear to be regulated by the turbulence drive rather than by their damping rate. It is also shown that the GAM amplitude is ~20% larger in deuterium than in hydrogen plasmas.EURATOM 633053Fundação para a Ciência e Tecnologia UID/FIS/50010/201

Water soluble Invar 36 feedstock development for µPIM

A water soluble binder system based on cellulose acetate butyrate (CAB) and polyethylene glycol (PEG) is proposed and investigated to carry out a micro powder injection moulding (muPIM) process with an Invar 36 alloy powders. The overall process was optimised with an emphasis on the determination of the optimal solid loading. Several methodologies were evaluated and compared to determine this parameter. A full muPIM was performed with different powder content feedstocks. Dog bone-type micro test parts were fabricated thereof and their mechanical properties were evaluated. Solid loadings up to 65 vol.% resulted to have the most equilibrated properties to successfully fabricate Invar 36 micro parts with the selected powder and binder system.The authors wish to thank GUZMÁN GLOBAL S.L. and MIMTECH ALFA for their collaboration on the ECOPIM project (Ref. IPT-2011-0931-20000) that was funded by the Spanish Ministry of the Economy and Competitiveness. Furthermore, the authors would like to acknowledge the strong support from the ESTRUMAT projects (Ref. S2009/MAT-1585), which were funded by the CAM Consejería Educación Dir. Gral. Universidades e Investigación, and from the COMETAS project (Ref. MAT2009/14448-C02-02), which was funded by the Spanish Ministry of the Economy and Competitiveness.Publicad

Resilience dynamics and productivity-driven shifts in the marine communities of the Western Mediterranean Sea

Ecological resilience has become a conceptual cornerstone bridging ecological processes to conservation needs. Global change is increasingly associated with local changes in environmental conditions that can cause abrupt ecosystem reorganizations attending to system-specific resilience fluctuations with time (i.e. resilience dynamics). Here we assess resilience dynamics associated with climate-driven ecosystems transitions, expressed as changes in the relevant contribution of species with different life-history strategies, in two benthopelagic systems. We analysed data from 1994 to 2019 coming from a scientific bottom trawl survey in two environmentally contrasting ecosystems in the Western Mediterranean Sea—Northern Spain and Alboran Sea. Benthopelagic species were categorized according to their life-history strategies (opportunistic, periodic and equilibrium), ecosystem functions and habitats. We implemented an Integrated Resilience Assessment (IRA) to elucidate the response mechanism of the studied ecosystems to several candidate environmental stressors and quantify the ecosystems’ resilience. We demonstrate that both ecosystems responded discontinuously to changes in chlorophyll-a concentration more than any other stressor. The response in Northern Spain indicated a more overarching regime shift than in the Alboran Sea. Opportunistic fish were unfavoured in both ecosystems in the recent periods, while invertebrate species of short life cycle were generally favoured, particularly benthic species in the Alboran Sea. The study illustrates that the resilience dynamics of the two ecosystems were mostly associated with fluctuating productivity, but subtle and long-term effects from sea warming and fishing reduction were also discernible. Such dynamics are typical of systems with wide environmental gradient such as the Northern Spain, as well as systems with highly hydrodynamic and of biogeographical complexity such as the Alboran Sea. We stress that management should become more adaptive by utilizing the knowledge on the systems’ productivity thresholds and underlying shifts to help anticipate both short-term/less predictable events and long-term/expected effects of climate change.En prensa2,27

The impact of rational surfaces on radial heat transport in TJ-II

Autor colectivo: TJ-II TeamIn this work, we study the outward propagation of temperature perturbations. For this purpose, we apply an advanced analysis technique, transfer entropy, to ECE measurements performed in ECR heated discharges at the low-shear stellarator TJ-II. We observe that the propagation of these perturbations is not smooth, but is slowed down at specific radial positions, near 'trapping zones' characterized by long time lags with respect to the perturbation origin. We also detect instances of rapid or instantaneous (non-local) propagation, in which perturbations appear to 'jump over' specific radial regions. The analysis of perturbations introduced in a resistive magneto-hydrodynamic model of the plasma leads to similar results. The radial regions corresponding to slow radial transport are identified with maxima of the flow shear associated with rational surfaces (mini-transport barriers). The non-local interactions are ascribed to MHD mode coupling effects

Identification of circulating microRNA profiles associated with pulmonary function and radiologic features in survivors of SARS-CoV-2-induced ARDS

ABSTRACT There is a limited understanding of the pathophysiology of postacute pulmonary sequelae in severe COVID-19. The aim of current study was to define the circulating microRNA (miRNA) profiles associated with pulmonary function and radiologic features in survivors of SARS-CoV-2-induced ARDS. The study included patients who developed ARDS secondary to SARS-CoV-2 infection (n=167) and a group of infected patients who did not develop ARDS (n=33). Patients were evaluated 3 months after hospital discharge. The follow-up included a complete pulmonary evaluation and chest computed tomography. Plasma miRNA profiling was performed using RT-qPCR. Random forest was used to construct miRNA signatures associated with lung diffusing capacity for carbon monoxide (DLCO) and total severity score (TSS). Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) enrichment analyses were conducted. DLCO<80% predicted was observed in 81.8% of the patients. TSS showed a median [P25;P75] of 5 [2;8]. The miRNA model associated with DLCO comprised miR-17-5p, miR-27a-3p, miR-126-3p, miR-146a-5p and miR-495-3p. Concerning radiologic features, a miRNA signature composed by miR-9-5p, miR-21-5p, miR-24-3p and miR-221-3p correlated with TSS values. These associations were not observed in the non-ARDS group. KEGG pathway and GO enrichment analyses provided evidence of molecular mechanisms related not only to profibrotic or anti-inflammatory states but also to cell death, immune response, hypoxia, vascularization, coagulation and viral infection. In conclusion, diffusing capacity and radiological features in survivors from SARS-CoV-2-induced ARDS are associated with specific miRNA profiles. These findings provide novel insights into the possible molecular pathways underlying the pathogenesis of pulmonary sequelae. Trial registration: ClinicalTrials.gov identifier: NCT04457505.. Trial registration: ISRCTN.org identifier: ISRCTN16865246..This work is supported by Instituto de Salud Carlos III (COV20/00110), co-funded by European Regional Development Fund (ERDF)/“A way to make Europe”. CIBERES is an initiative of the Instituto de Salud Carlos III. CIBERES is an initiative of the Instituto de Salud Carlos III. Suported by: Programa de donaciones "estar preparados" UNESPA (Madrid, Spain) and Fundación Francisco Soria Melguizo (Madrid, Spain).. Finançat per La Fundació La Marató de TV3, projecte amb codi 202108-30/-31. COVIDPONENT is funded by Institut Català de la Salut and Gestió de Serveis Sanitaris. MM is the recipient of a predoctoral fellowship (PFIS: FI21/00187) from Instituto de Salud Carlos III. MCGH is the recipient of a predoctoral fellowship from “University of Lleida”. DdGC has received financial support from Instituto de Salud Carlos III (Miguel Servet 2020: CP20/00041), co-funded by the European Social Fund (ESF)/“Investing in your future”. ENL and GL were funded by COVID1005 and ACT210085 from National Agency of Investigation & Development (ANID), Chile."Article signat per 27 autors/es: María C. García-Hidalgo, Jessica González, Iván D. Benítez, Paola Carmona, Sally Santisteve, Manel Pérez-Pons, Anna Moncusí-Moix, Clara Gort-Paniello, Fátima Rodríguez-Jara, Marta Molinero, Thalia Belmonte, Gerard Torres, Gonzalo Labarca, Estefania Nova-Lamperti, Jesús Caballero, Jesús F. Bermejo-Martin, Adrián Ceccato, Laia Fernández-Barat, Ricard Ferrer, Dario Garcia-Gasulla, Rosario Menéndez, Ana Motos ,Oscar Peñuelas, Jordi Riera, Antoni Torres, Ferran Barbé, David de Gonzalo-Calvo & on behalf of the CIBERESUCICOVID Project (COV20/00110 ISCIII)"Postprint (published version

Temperature and current flow effects of different electrode placement in shoulder capacitive-resistive electric transfer applications: a cadaveric study

Background: Impingement syndrome is currently estimated to represent 60% of all shoulder pain disorders. Capacitive-Resistive electric transfer therapy is aimed to provoke temperature and current flow changes in superficial and deep tissues. This in vitro study has evaluated the variation of temperature and current flow in the shoulder tissues during two different areas of application of the movable capacitive-resistive electric transfer electrode. Methods: A cross-sectional study designed, five fresh cryopreserved cadavers (10 shoulders) were included in this study. Four interventions (capacitive and resistive modes; low- and high-power) were performed for 5 min each by a diathermy “T-Plus” device in two shoulder regions: postero-superior and antero-lateral. Supraspinatus tendon, glenohumeral capsule and superficial temperatures were recorded at 1-min intervals and 5 min after treatment. Results: A statistically significant difference was found only for the superficial area and time interaction, with high power-resistive application at the postero-superior shoulder area (P< 0.035). All the applications showed a 5 min after treatment temperature increase compared with the basal data, in all the application points. Superficial temperature in the high power-resistive application showed the greatest percent increase (42.93% ± 22.58), followed by the temperature in the tendon area with the same high power-resistive application (22.97% ± 14.70). The high power-resistive application showed the greatest percent of temperature increase in the applications, reaching 65.9% ± 22.96 at 5-min at the superficial level, and 32% ± 24.25 at 4-min at the level of the supraspinatus tendon. At the capsule level, high power-resistive was also the application that showed the greatest percent of increase, with 21.52% ± 16.16. The application with the lowest percent of temperature increase was the low power-capacitive, with a mean value of 4.86% at supraspinatus tendon level and 7.47% at capsular level. Conclusion: The shoulder postero-superior or antero-lateral areas of application of capacitive-resistive electric transfer did not cause statistically significant differences in the temperature changes in either supraspinatus tendon or glenohumeral capsule tissues in cadaveric samples. The high power-resistive application in the postero-superior area significantly increased superficial temperature compared with the same application in the antero-lateral position area