Acceleration predicts energy expenditure in a fat, flightless, diving bird

Funding The project was supported logistically by the French Polar Institute and funded by the PEW fellowship to Y.R.-C., the WWF-UK, and the Zone Atelier Antarctique et Terres Australes from the CNRS. D.M.W. received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska‐Curie Individual Fellowship Grant Agreement No. 748026.Peer reviewedPublisher PD

Amiloride Derivative Compound 10357 in the Treatment of B-Cell Acute Lymphoblastic Leukemia

Compound 10357 is an amiloride derivative with potential promise as an adjunct to current chemotherapeutics. This study investigates the therapeutic efficacy of Compound 10357 in B-Cell Acute Lymphoblastic Leukemia (B-ALL)

Prospective, multisite, international comparison of \u3csup\u3e18\u3c/sup\u3eF-fluoromethylcholine PET/CT, multiparametric MRI, and \u3csup\u3e68\u3c/sup\u3eGa-HBED-CC PSMA-11 PET/CT in men with high-risk features and biochemical failure after radical prostatectomy: Clinical performance and patient outcomes

A significant proportion of men with rising prostate-specific antigen (PSA) levels after radical prostatectomy (RP) fail prostate fossa (PF) salvage radiation treatment (SRT). This study was done to assess the ability of F-fluoromethylcholine ( F-FCH) PET/CT (hereafter referred to as F-FCH), Ga-HBED-CC PSMA-11 PET/CT (hereafter referred to as PSMA), and pelvic multiparametric MRI (hereafter referred to as pelvic MRI) to identify men who will best benefit from SRT. Methods: Prospective, multisite imaging studies were carried out in men who had rising PSA levels after RP, high-risk features, and negative/equivocal conventional imaging results and who were being considered for SRT. F-FCH (91/91), pelvic MRI (88/91), and PSMA (31/91) (Australia) were all performed within 2 wk. Imaging was interpreted by experienced local/central interpreters who were masked with regard to other imaging results, with consensus being reached for discordant interpretations. Expected management was documented before and after imaging, and data about all treatments and PSA levels were collected for 3 y. The treatment response to SRT was defined as a reduction in PSA levels of .50% without androgen deprivation therapy. Results: The median Gleason score, PSA level at imaging, and PSA doubling time were 8, 0.42 (interquartile range, 0.29–0.93) ng/mL, and 5.0 (interquartile range, 3.3–7.6) months. Recurrent prostate cancer was detected in 28% (25/88) by pelvic MRI, 32% (29/91) by F-FCH, and 42% (13/31) by PSMA. This recurrence was found within the PF in 21.5% (19/88), 13% (12/91), and 19% (6/31) and at sites outside the PF (extra-PF) in 8% (7/88), 19% (17/91), and 32% (10/31) by MRI, F-FCH, and PSMA, respectively (P, 0.004). A total of 94% (16/17) of extra-PF sites on F-FCH were within the pelvic MRI field. Intra-pelvic extra-PF disease was detected in 90% (9/10) by PSMA and in 31% (5/16) by MRI. F-FCH changed management in 46% (42/91), and MRI changed management in 24% (21/88). PSMA provided additional management changes over F-FCH in 23% (7/31). The treatment response to SRT was higher in men with negative results or disease confined to the PF than in men with extra-PF disease ( F-FCH 73% [32/44] versus 33% [3/9] [P, 0.02], pelvic MRI 70% [32/46] versus 50% [2/4] [P was not significant], and PSMA 88% [7/ 8] versus 14% [1/7] [P, 0.005]). Men with negative imaging results (MRI, F-FCH, or PSMA) had high (78%) SRT response rates. Conclusion: F-FCH and PSMA had high detection rates for extra-PF disease in men with negative/equivocal conventional imaging results and rising PSA levels after RP. These findings affected management and treatment responses, suggesting an important role for PET in triaging men being considered for curative SRT. 18 18 18 68 18 18 18 18 18 18 18 18 1

The 2020 plasma catalysis roadmap

International audienc

RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients

Rheumatoid arthritis (RA) is a chronic inflammatory disorder with poorly defined aetiology characterised by synovial inflammation with variable disease severity and drug responsiveness. To investigate the peripheral blood immune cell landscape of early, drug naive RA, we performed comprehensive clinical and molecular profiling of 267 RA patients and 52 healthy vaccine recipients for up to 18 months to establish a high quality sample biobank including plasma, serum, peripheral blood cells, urine, genomic DNA, RNA from whole blood, lymphocyte and monocyte subsets. We have performed extensive multi-omic immune phenotyping, including genomic, metabolomic, proteomic, transcriptomic and autoantibody profiling. We anticipate that these detailed clinical and molecular data will serve as a fundamental resource offering insights into immune-mediated disease pathogenesis, progression and therapeutic response, ultimately contributing to the development and application of targeted therapies for RA.</p

Study of forward Z + jet production in pp collisions at √s=7 TeV

A measurement of the $Z(\rightarrow\mu^+\mu^-)$+jet production cross-section in $pp$ collisions at a centre-of-mass energy $\sqrt{s} = 7$ TeV is presented. The analysis is based on an integrated luminosity of $1.0\,\text{fb}^{-1}$ recorded by the LHCb experiment. Results are shown with two jet transverse momentum thresholds, 10 and 20 GeV, for both the overall cross-section within the fiducial volume, and for six differential cross-section measurements. The fiducial volume requires that both the jet and the muons from the Z boson decay are produced in the forward direction ($2.0<\eta<4.5$). The results show good agreement with theoretical predictions at the second-order expansion in the coupling of the strong interaction.A measurement of the $Z(\rightarrow\mu^+\mu^-)$+jet production cross-section in $pp$ collisions at a centre-of-mass energy $\sqrt{s} = 7$ TeV is presented. The analysis is based on an integrated luminosity of $1.0\,\text{fb}^{-1}$ recorded by the LHCb experiment. Results are shown with two jet transverse momentum thresholds, 10 and 20 GeV, for both the overall cross-section within the fiducial volume, and for six differential cross-section measurements. The fiducial volume requires that both the jet and the muons from the Z boson decay are produced in the forward direction ($2.0<\eta<4.5$). The results show good agreement with theoretical predictions at the second-order expansion in the coupling of the strong interaction

GRAULICH, M. — Montezuma, ou l'apogée et la chute de l'empire aztèque

Hicks Frederic. GRAULICH, M. — Montezuma, ou l'apogée et la chute de l'empire aztèque. In: Journal de la Société des Américanistes. Tome 82, 1996. pp. 387-389

&quot;flowery war&quot; in Aztec history

A notion that has captured the imagination of many modern writers on Aztec Mexico is that the Aztec believed so fervently in the need to nourish their gods with the blood of human sacrifices that they developed an institution called &quot;flowery war&quot; (xochiyaoyotl) for the express purpose of supplying this need. The early sources on the Aztec give little support to this notion. There were indeed &quot;flowery wars&quot; in ancient Mexico. But were they waged primarily to obtain sacrificial victims? Were such victims normally even obtained through them? These questions have implications beyond the immediate concern with Aztec warfare and sacrifice. Are wars in state-level societies ever initiated for purely religious or ritual reasons? To be sure, the prominence of an official cult in many preindustrial states gives to most wars, whatever their motives or objectives, a religious aspect; and even in modern states, religion often serves to legitimize a protest begun for other reasons. For example, one can think of the nineteenth-century Moslem jihads of western Africa, the recent civil strife in Northern Ireland, and of course, the Medieval European Crusades (see also the cases discussed in various papers in Thrupp 1962). In none of these instances is it difficult to see beneath the religious cloak to the underlying material causes and issues. If Aztec states really fought wars solely to satisfy the ritual requirements of their religious beliefs, it would be a very unusual case indeed, and it is not surprising that both Harner and Price suspected there was something more to it. In this paper, I will examine the data on wars called &quot;flowery&quot; in the ethnohistorical sources. Such data are not abundant, but they do suggest that sacrificial victims were at best an incidental and occasional by-product of flowery wars, and that the primary function of these wars was a much more practical one. One of the sources that tells us the most about flowery war is Chimalpahin Quauhtlehuanitzin, a descendant of the ruling family of Amecameca, whose historical relations, written in the early seventeenth century, were based on earlier pictorial sources and oral traditions (Romero Galvan 1977). It is from Chimalpahin that we get the most explicit stateThe notion that the Aztec fought &quot;flowery wars&quot; primarily to provide captives needed for human sacrifice is called into question. The data on wars called &quot;flowery&quot; in the ethnohistorical sources indicate that they were simply wars not aimed at conquest, and that the most common motive for waging them was to provide military training and practice. Aztec flowery war 8