Numerical Simulations of Gravity Waves Imaged Over Arecibo During the 10-Day January 1993 Campaign

Recently, measurements were made of mesospheric gravity waves in the OI (5577 Å) nightglow observed from Arecibo, Puerto Rico, during January 1993 as part of a special 10-day campaign. Clear, monochromatic gravity waves were observed on several nights. By using a full-wave model that realistically includes the major physical processes in this region, we have simulated the propagation of two waves through the mesopause region and calculated the O(1 S) nightglow response to the waves. Mean winds derived from both UARS wind imaging interferometer (WINDII) and Arecibo incoherent scatter radar observations were employed in the computations as were the climatological zonal winds defined by COSPAR International Reference Atmosphere 1990 (CIRA). For both sets of measured winds the observed waves encounter critical levels within the O(1 S) emission layer, and wave amplitudes, derived from the requirement that the simulated and observed amplitudes of the O(1 S) fluctuations be equal, are too large for the waves to be gravitationally stable below the emission layer. Some of the model coefficients were adjusted in order to improve the agreement with the measurements, including the eddy diffusion coefficients and the height of the atomic oxygen layer. The effect of changing the chemical kinetic parameters was investigated but was found to be unimportant. Eddy diffusion coefficients that are 10 to 100 times larger than presently accepted values are required to explain most of the observations in the cases that include the measured background winds, whereas the observations can be modeled using the nominal eddy diffusion coefficients and the CIRA climatological winds. Lowering the height of the atomic oxygen layer improved the simulations slightly for one of the simulated waves but caused a less favorable simulation for the other wave. For one of the waves propagating through the WINDII winds the simulated amplitude was too large below 82 km for the wave to be gravitationally stable, in spite of the adjustments made to the model parameters. This study demonstrates that an accurate description of the mean winds is an essential requirement for a complete interpretation of observed wave-driven airglow fluctuations

Genetic effects on gene expression across human tissues

Characterization of the molecular function of the human genome and its variation across individuals is essential for identifying the cellular mechanisms that underlie human genetic traits and diseases. The Genotype-Tissue Expression (GTEx) project aims to characterize variation in gene expression levels across individuals and diverse tissues of the human body, many of which are not easily accessible. Here we describe genetic effects on gene expression levels across 44 human tissues. We find that local genetic variation affects gene expression levels for the majority of genes, and we further identify inter-chromosomal genetic effects for 93 genes and 112 loci. On the basis of the identified genetic effects, we characterize patterns of tissue specificity, compare local and distal effects, and evaluate the functional properties of the genetic effects. We also demonstrate that multi-tissue, multi-individual data can be used to identify genes and pathways affected by human disease-associated variation, enabling a mechanistic interpretation of gene regulation and the genetic basis of diseas

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

Genetic effects on gene expression across human tissues

Characterization of the molecular function of the human genome and its variation across individuals is essential for identifying the cellular mechanisms that underlie human genetic traits and diseases. The Genotype-Tissue Expression (GTEx) project aims to characterize variation in gene expression levels across individuals and diverse tissues of the human body, many of which are not easily accessible. Here we describe genetic effects on gene expression levels across 44 human tissues. We find that local genetic variation affects gene expression levels for the majority of genes, and we further identify inter-chromosomal genetic effects for 93 genes and 112 loci. On the basis of the identified genetic effects, we characterize patterns of tissue specificity, compare local and distal effects, and evaluate the functional properties of the genetic effects. We also demonstrate that multi-tissue, multi-individual data can be used to identify genes and pathways affected by human disease-associated variation, enabling a mechanistic interpretation of gene regulation and the genetic basis of disease

Window on a war : An anthropologist in the Vietnam conflict

xix, 395 p. : ill, map ; 21 cm

The highland people of South Vietnam : Social and economic development

xiv, 190 p. ; 21 cm