MIGHTEE : total intensity radio continuum imaging and the COSMOS/XMM-LSS Early Science fields

Please read abstract in the article.The UK Science and Technology Facilities Council; the South African Radio Astronomy Observatory; the Leverhulme Trust through an Early Career Research Fellowship; the South African Research Chairs Initiative of the Department of Science and Technology; the National Research Foundation; the Science and Technology Foundation (FCT, Portugal); the UK STFC ; the South African Research Chairs Initiative of the Department of Science and Innovation; the Bundesministerium für Bildung und Forschung (BMBF); the Italian Ministry of Foreign Affairs and International Cooperation; the South African Department of Science and Technology’s National Research Foundation (DST-NRF).https://academic.oup.com/mnrashj2022Physic

Number preferences in lotteries

We explore people's preferences for numbers in large proprietary data sets from two different lottery games. We find that choice is far from uniform, and exhibits some familiar and some new tendencies and biases. Players favor personally meaningful and situationally available numbers, and are attracted towards numbers in the center of the choice form. Frequent players avoid winning numbers from recent draws, whereas infrequent players chase these. Combinations of numbers are formed with an eye for aesthetics, and players tend to spread their numbers relatively evenly across the possible range

CSF pro-orexin and amyloid-β38 expression in Alzheimer's disease and frontotemporal dementia

There is an unmet need for markers that can stratify different forms and subtypes of dementia. Because of similarities in clinical presentation, it can be difficult to distinguish between Alzheimer's disease (AD) and frontotemporal dementia (FTD). Using a multiplex targeted proteomic LC-MS/MS platform, we aimed to identify cerebrospinal fluid proteins differentially expressed between patients with AD and FTD. Furthermore analysis of 2 confirmed FTD genetic subtypes carrying progranulin (GRN) and chromosome 9 open reading frame 72 (C9orf72) mutations was performed to give an insight into the differing pathologies of these forms of FTD. Patients with AD (n = 13) demonstrated a significant (p 2-fold reduction (p < 0.0001) in the FTD group compared to controls and a similar 1.83-fold reduction compared to the AD group (p < 0.001). Soluble TREM2 was elevated in both dementia groups but did not show any difference between AD and FTD. A further analysis comparing FTD subgroups revealed slightly lower levels of proteins apolipoprotein E, CD166, osteopontin, transthyretin, and cystatin C in the GRN group (n = 9) compared to the C9orf72 group (n = 7). These proteins imply GRN FTD elicits an altered inflammatory response to C9orf72 FTD

Predicting LIF Signal Strength for Toluene and 3-Pentanone under Engine-Related Temperature and Pressure Conditions

Laser-induced fluorescence (LIF) imaging of mixing processes frequently employs 3-pentanone or toluene as a fluorescence tracer. The analysis of measured LIF signals typically requires corrections for the influence of temperature, pressure, and gas composition on the signal strength in cases where these variables are not constant for the process under study, e.g., in internal combustion engines. However, fluorescence quantum yield data at simultaneous high temperature and high pressure are not well characterized. Therefore, the ability of two fluorescence models to predict the signal strength for 3-pentanone and toluene, respectively, under those conditions has been evaluated through comparison to LIF measurements using 248 nm excitation in a motored optical engine. The temperature-pressure manifold that was covered ranges from 0.45 bar, 328 K to 8 bar, 600 K. A semi-empirical, photophysical model for 3-pentanone combines the effects of temperature, pressure, and excitation wavelength on fluorescence quantum yield. The qualitative influences of p and T reflect an increasing non-radiative decay rate with the excited electronic state's vibrational energy level and the tendencies of collisions to remove the excess vibrational energy. The model for toluene seeks to quantify the fluorescence quantum yield via the effects of intra-molecular deactivation as well as collisional deactivation dominated by molecular oxygen. Model-predicted LIF signal strengths for 3-pentanone did not capture the signal modulations measured under the engine conditions, but agreement was much better using predictions based directly on the measured temperature and pressure dependencies in cell experiments. The toluene LIF model is able to reproduce the observed LIF signal strength in the engine with good accuracy. It is shown that quantitative analysis of toluene LIF requires knowledge of temperature and oxygen partial pressure. Therefore, the frequently applied assumption that the toluene-LIF signal is proportional to the equivalence ratio is not correct for the range of pressures and temperatures typical for the compression stroke in internal combustion engines.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/86747/1/Sick23.pd