From the womb into the world:Protecting the fetal brain from maternal stress during pregnancy

No other period in a child's life matches the speed of brain development than the first nine months in the womb. Rapid growth goes hand in hand with enormous potential, but also with great vulnerability. This policy-focused review focuses on maternal mental health as a key factor for fetal brain development. Already during pregnancy, the fetal brain wires differently when exposed to maternal stress, and children prenatally exposed to stress have a higher risk of developing neurodevelopmental disorders. Maternal prenatal stress is preventable, treatable, and tractable by policy. Research-based, policy recommends: (1) screening for maternal mental health issues throughout pregnancy, (2) encourage talking about prenatal mental health, (3) evidence-based interventions for pregnant women with mental health issues, (4) avoiding stress-inducing communication towards pregnant women, and (5) stimulating positive postnatal parenting. Investing in healthy pregnancies will improve fetal brain growth, and, ultimately lead to a healthier next generation

Acceleration of mass transfer in methane-producing loop reactors

Gas bubbles entrapped in methanogenic granules subjected to hydrostatic pressure oscillations during recirculation in loop reactors will induce intraparticle liq. flows and thereby enhance mass transfer in excess of diffusion. This 'breathing particle' concept was clearly demonstrated in a well defined inorg. model system. The exptl. results could be described satisfactory with a structured math. model, in which a 30% improvement is predicted for methanogenic loop reactors as compared to const. pressure systems. It is concluded that acceleration of mass transfer in gas-producing systems offers challenging perspectives for both heterogeneous catalysis and biol. fermns. [on SciFinder (R)

Properties of Deflagration Fronts and Models for Type Ia Supernovae

Detailed models of the explosion of a white dwarf, which include self-consistent calculations of the light curve and spectra, provide a link between observational quantities and the underlying explosion.These calculations assume spherical geometry and are based on parameterized descriptions of the burning front during the deflagration phase. Recently, first multi-dimensional calculations for nuclear burning fronts have been performed. Although a fully consistent treatment of the burning fronts is beyond the current state of the art, these calculations provided a new and better understanding of the physics, and new descriptions for the flame propagation have been proposed. Here, we have studied the influence on the results of previous analyses of Type Ia Supernovae, namely, the nucleosynthesis and structure of the expanding envelope. Our calculations are based on a set of delayed detonation models with parameters that give a good account of the optical and infrared light curves, and of the spectral evolution. In this scenario, the burning front propagates first in a deflagration mode and, subsequently, turns into a detonation. The explosions and light curves are calculated using a one-dimensional Lagrangian radiation-hydro code, including a detailed nuclear network.Comment: 9 pages, 4 figures, macros 'crckapb.sty'. The Astrophysical Journal (accepted

Paternal bonding in pregnancy and early parenthood:A qualitative study in first-time fathers

The birth of an infant marks a period of profound change in first-time parents. Parental love and warmth, however, already begin to develop during pregnancy. Also for fathers, the development of bonding to the infant may be a unique process. The current qualitative study aimed to explore views and experiences of first-time fathers on the origins and development of paternal bonding during pregnancy and early childhood. In total, 30 in-depth semi-structured interviews were conducted with expectant fathers (second or third trimester of pregnancy; n = 10) and fathers of infants (0–6 months postpartum; n = 11) and toddlers (2–3 years of age; n = 9). Two major themes were uncovered from the data: feelings of bonding and facilitators of bonding. The first theme was supported with three subthemes: 1) from abstract to concrete, 2) positive emotions, and 3) uncertainties and worries. The second theme, facilitators of bonding, was supported with four subthemes: 1) experiencing the foetus, 2) meeting the child, 3) interaction, and 4) communication. Similar to previous studies, our results suggested that, in most fathers, paternal bonding originates in pregnancy and that it evolves over time. Seeing or feeling the child, both during pregnancy and postpartum, as well as interacting or communicating with the child, appears to facilitate fathers’ feelings of bonding. Involving fathers in pregnancy, childbirth, and parenting may be essential for their bonding process

How to inform at-risk relatives?:Attitudes of 1379 Dutch patients, relatives, and members of the general population

The uptake of predictive DNA testing in families with a hereditary disease is <50%. Current practice often relies on the proband to inform relatives about the possibility of predictive DNA testing, but not all relatives are informed adequately. To enable informed decision-making concerning predictive DNA testing, the approach used to inform at-risk relatives needs to be optimized. This study investigated the preferences of patients, relatives, and the general population from the Netherlands on how to inform relatives at risk of autosomal dominant diseases. Online surveys were sent to people with autosomal dominant neuro-, onco-, or cardiogenetic diseases and their relatives via patient organizations (n = 379), and to members of the general population via a commercial panel (n = 1,000). Attitudes of the patient and population samples generally corresponded. A majority believed that initially only first-degree relatives should be informed, following the principles of a cascade screening approach. Most participants also thought that probands and healthcare professionals (HCPs) should be involved in informing relatives, and a large proportion believed that HCPs should contact relatives directly in cases where patients are unwilling to inform, both for untreatable and treatable conditions. Participants from the patient sample were of the opinion that HCPs should actively offer support. Our findings show that both patients and HCPs should be involved in informing at-risk relatives of autosomal dominant diseases and suggest that relatives' 'right to know' was considered a dominant issue by the majority of participants. Further research is needed on how to increase proactive support in informing of at-risk relatives

The host galaxy of GRB010222: The strongest damped Lyman-alpha system known

Analysis of the absorption lines in the afterglow spectrum of the gamma-ray burst GRB010222 indicates that its host galaxy (at a redshift of z=1.476) is the strongest damped Lyman-alpha (DLA) system known, having a very low metallicity and modest dust content. This conclusion is based on the detection of the red wing of Lyman-alpha plus a comparison of the equivalent widths of ultraviolet Mg I, Mg II, and Fe II lines with those in other DLAs. The column density of H I, deduced from a fit to the wing of Lyman-alpha, is (5 +/- 2) 10^22 cm^-2. The ratio of the column densities of Zn and Cr lines suggests that the dust content in our line of sight through the galaxy is low. This could be due to either dust destruction by the ultraviolet emission of the afterglow or to an initial dust composition different to that of the diffuse interstellar material, or a combination of both.Comment: Submitted to MNRAS 12 page