The I-mode confinement regime at ASDEX Upgrade: global propert ies and characterization of strongly intermittent density fluctuations

Properties of the I­mode confinement regime on the ASDEX Upgrade tokamak are summarized. A weak dependence of the power threshold for the L­I transition on the toroidal magnetic field strength is found. During improved confinement, the edge radial electric field well deepens. Stability calculations show that the I­mode pedestal is peeling­ballooning stable. Turbulence investigations reveal strongly intermittent density fluctuations linked to the weakly coherent mode in the confined plasma, which become stronger as the confinement quality increases. Across all investigated structure sizes ( ≈ ⊥ k 5 – 12 cm − 1 , with ⊥ k the perpendicular wavenumber of turbulent density fluctuations), the intermittent turbulence bursts are observed. Comparison with bolometry data shows that they move poloidally toward the X­point and finally end up in the divertor. This might be indicative that they play a role in inhibiting the density profile growth, such that no pedestal is formed in the edge density profile.European Union (EUROfusion 633053)European Union (EUROfusion AWP15­ENR­09/IPP­02

Evolution of surface velocities and ice discharge of Larsen B outlet glaciers from 1995 to 2013

We use repeat-pass SAR data to produce detailed maps of surface motion covering the glaciers draining into the former Larsen B ice shelf, Antarctic Peninsula, for different epochs between 1995 and 2013. We combine the velocity maps with estimates of ice thickness to analyze fluctuations of ice discharge. The collapse of the central and northern sections of the ice shelf in 2002 led to a near-immediate acceleration of tributary glaciers as well as of the remnant ice shelf in Scar Inlet. Velocities of the glaciers discharging directly into the ocean remain to date well above the velocities of the pre-collapse period. The response of individual glaciers differs and velocities show significant temporal fluctuations, implying major variations in ice discharge and mass balance as well. Due to reduced velocity and ice thickness the ice discharge of Crane Glacier decreased from 5.02 Gt a−1 in 2007 to 1.72 Gt a−1 in 2013, whereas Hektoria and Green glaciers continue to show large temporal fluctuations in response to successive stages of frontal retreat. The velocity on Scar Inlet ice shelf increased two- to three fold since 1995, with the largest increase in the first years after the break-up of the main section of Larsen B. Flask and Leppard glaciers, the largest tributaries to Scar Inlet ice shelf, accelerated. In 2013 their discharge was 38% and 46%, higher than in 1995

Observation of Strongly Intermittent Density Turbulence in ASDEX Upgrade I-mode plasmas

International audienc

Turbulence characteristics of the I-mode confinement regime in ASDEX Upgrade

International audienceBesides strong geodesic acoustic mode (GAM) activity, turbulence in the I-mode confinement regime of ASDEX Upgrade exhibits two prominent features, the weakly coherent mode (WCM) and strongly intermittent solitary density perturbations. The nonlinear interaction between these structures is studied in detail by means of a conditional averaged wavelet-bicoherence analysis. The wavelet analysis reveals that these density perturbations are at the WCM frequency. The GAM is coupled to all frequency scales of the velocity fluctuations via a modulational instability. The WCM shows coupling to higher frequencies prior to the bursts, indicating a process resembling wave-steepening. A possible mechanism for the generation of such solitary density perturbations by a Korteweg?de Vries-like nonlinearity is discussed

Supplementary Material for: Downregulation of the Ubiquitin-Proteasome System in Normal Colonic Macrophages and Reinduction in Inflammatory Bowel Disease

<b><i>Background:</i></b> In normal mucosa, intestinal lamina propria macrophages (IMACs) maintain tolerance against food antigens and the commensal bacterial flora. Several mechanisms have been identified that mediate tolerance. The ubiquitin-proteasome system (UPS) is a large multiprotein complex that degrades cellular proteins. As the UPS may modulate immune functions of IMACs, we performed a detailed investigation of UPS expression and function under normal conditions and in cells derived from patients suffering from inflammatory bowel disease (IBD).<b><i> Methods:</i></b> IMACs were isolated from intestinal mucosa. mRNA expression of macrophages differentiated in vitro (i.v. MACs) and IMACs was compared by Affymetrix® oligonucleotide arrays. Quantitative Taqman-PCR was performed on five exemplary proteasomal and five ubiquitinylation genes each. Proteins were analyzed by immunohistochemistry and Western blotting. Proteasome function was assessed by a fluorimetric test. <b><i>Results:</i></b> Affymetrix analysis showed downregulation of mRNA expression of almost all represented proteasomal and of 22 ubiquitination-associated genes in IMACs as compared to i.v. MACs and monocytes. By quantitative PCR, up to tenfold higher mRNA expression of 10 exemplary genes of the UPS (UBE2A, UBE2D2, UBE2L6, USP14, UBB and ATPase2, β2, β5, β2i/MECL-1, β5i/LMP7) was demonstrated in i.v. MACs as compared to IMACs. Immunohistochemistry and Western blots confirmed these findings in intestinal mucosa of controls and patients suffering from diverticulitis. In contrast, a significant increase in protein amounts was found in mucosa of patients with IBD. <b><i>Conclusion:</i></b> Reduced expression of subunits of the UPS in IMACs of normal mucosa supports the concept of the presence of a nonreactive, anergic macrophage phenotype in the gut under normal conditions. Reinduction in IMACs of IBD mucosa reflects activated IMACs which can present antigenic peptides and thus support inflammation