The Stellar Populations of the Carina Dwarf Spheroidal Galaxy: I. a New Color-Magnitude Diagram for the Giant and Horizontal Branches

We report on the first in a series of studies of the Carina dwarf spheroidal galaxy, a nearby satellite of our Galaxy. Our two major results are: 1) precise BI photometry (\sigma_{B-I} \simlt 0.05 for V \simlt 22) for 11,489 stars in the Carina field, and 2) the detection of two, morphologically distinct, horizontal branches, which confirms that star formation in Carina occurred in two well-separated episodes. The old horizontal branch and RR Lyrae instability strip belong to a > 10 Gyr stellar population, while the populous red-clump horizontal branch belongs to an approximately 6 Gyr stellar population. We derive a distance modulus $(m-M)_0=20.09 \pm 0.06$ for Carina from the apparent magnitudes of the old horizontal branch and the tip of the red giant branch, and discuss modifications to the previously estimated distance, total magnitude, and stellar ages. Using the color of the red giant branch, we estimate the metallicities of the younger and older populations to be [Fe/H] = -2.0 and -2.2, respectively.Comment: 18 pages, 9 figures, uses AAS LaTex macros, PostScript figures available through anonymous ftp, accepted for publication in the Astronomical Journal, DAO-tsh94-

MuSK induces in vivo acetylcholine receptor clusters in a ligand-independent manner

Muscle-specific receptor tyrosine kinase (MuSK) is required for the formation of the neuromuscular junction. Using direct gene transfer into single fibers, MuSK was expressed extrasynaptically in innervated rat muscle in vivo to identify its contribution to synapse formation. Spontaneous MuSK kinase activity leads, in the absence of its putative ligand neural agrin, to the appearance of ε-subunit–specific transcripts, the formation of acetylcholine receptor clusters, and acetylcholinesterase aggregates. Expression of kinase-inactive MuSK did not result in the formation of acetylcholine receptor (AChR) clusters, whereas a mutant MuSK lacking the ectodomain did induce AChR clusters. The contribution of endogenous MuSK was excluded by using genetically altered mice, where the kinase domain of the MuSK gene was flanked by loxP sequences and could be deleted upon expression of Cre recombinase. This allowed the conditional inactivation of endogenous MuSK in single muscle fibers and prevented the induction of ectopic AChR clusters. Thus, the kinase activity of MuSK initiates signals that are sufficient to induce the formation of AChR clusters. This process does not require additional determinants located in the ectodomain

NGC 2419, M92, and the Age Gradient in the Galactic Halo

The WFPC2 camera on HST has been used to obtain deep main sequence photometry of the low-metallicity ([Fe/H]=-2.14), outer-halo globular cluster NGC 2419. A differential fit of the NGC 2419 CMD to that of the similarly metal-poor \ standard cluster M92 shows that they have virtually identical principal sequences and thus the same age to well within 1 Gyr. Since other low-metallicity clusters throughout the Milky Way halo have this same age to within the 1-Gyr precision of the differential age technique, we conclude that the earliest star (or globular cluster) formation began at essentially the same time everywhere in the Galactic halo throughout a region now almost 200 kpc in diameter. Thus for the metal-poorest clusters in the halo there is no detectable age gradient with Galactocentric distance. To estimate the absolute age of NGC 2419 and M92, we fit newly computed isochrones transformed through model-atmosphere calculations to the (M_V,V-I) plane, with assumed distance scales that represent the range currently debated in the literature. Unconstrained isochrone fits give M_V(RR) = 0.55 \pm 0.06 and a resulting age of 14 to 15 Gyr. Incorporating the full effects of helium diffusion would further reduce this estimate by about 1 Gyr. A distance scale as bright as M_V(RR) = 0.15 for [Fe/H] = -2, as has recently been reported, would leave several serious problems which have no obvious solution in the context of current stellar models.Comment: 32 pages, aastex, 9 postscript figures; accepted for publication in AJ, September 1997. Also available by e-mail from [email protected]

Analysis of linearized inverse problems in ultrasound transmission imaging

The purpose of this paper is to analyze the linearized inverse problem during the iterativesolution process of the ill-posed nonlinear inverse problem of image reconstruction for ultra-sound transmission imaging. We show that the conjugate gradient applied to normal equation(CGNE) method gives more reliable solutions for linearized systems than Tikhonov regular-ization methods. The linearized systems are more sensitive when treated by CGNE than byTikhonov regularization methods. The Tikhonov regularization is less effective at the be-ginning of the outer-loop iteration, where the nonlinearity is dominating while the conjugategradient for the linearized system stops earlier. Only when the linear approximation is goodenough to describe the whole system, Tikhonov regularization can fully play its role and giveslightly better reconstruction results as compared to CGNE in a very noisy case