Effects of biased feedback on learning and deciding in a vernier discrimination task

AbstractWe investigate the influence of biased feedback on decision and learning processes in a vernier discrimination task. Subjects adjust their decision criteria and hence their responses according to biased external feedback. However, they do not use learning processes to encode incorrectly classified stimuli. As soon as correct feedback is restored observers regain their original performance indicating an involvement of internal criteria. If the external feedback is switched off instead of being corrected, the rebound is less vigorous. The findings contradict predictions of supervised neural network models

Spatial aspects of object formation revealed by a new illusion, shine-through

When a vernier stimulus is presented for a short time and followed by a grating comprising five straight lines, the vernier remains invisible but may bequeath its offset to the grating (feature inheritance). For more than seven grating elements, the vernier is rendered visible as a shine-through element. However, shine-through depends strongly on the spatio-temporal layout of the grating. Here, we show that spatially inhomogeneous gratings diminish shine-through and vernier discrimination. Even subtle deviations, in the range of a few minutes of arc, matter. However, longer presentation times of the vernier regenerate shine-through. Feature inheritance and shine-through may become a useful tool in investigating such different topics as time course of information processing, feature binding, attention, and masking

Shine-through: temporal aspects

If a vernier stimulus precedes a grating for a very short time, the vernier either remains invisible, but may bequeath some of its properties to the grating (feature inheritance), or might shine through keeping its features — depending on the number of grating elements [Herzog, M. H. & Koch, C., 2001. Seeing properities of an invisible element: feature inheritance and shine-through. Proceedings of the Natlional Academy of Science USA 98, 4271–4275]. Feature inheritance and shine-through represent two different states of feature binding [Herzog, M. H., Koch, C., & Fahle, M., Switching binding states. Visual Cognition (in press)], whereas shine-through depends in subtle ways on the spatial layout of the grating [Herzog, M. H., Fahle, M., & Koch, C., (2001). Spatial aspects of object formation revealed by a new illusion, shine-through. Vision Research]. Here, we show that also temporal parameters of the grating influence shine-through. For example, a delayed presentation of certain grating elements can deteriorate performance dramatically

In Memorian for L.F.E. Goldie

Professor Louis Frederick Edward Goldie died suddenly of a heart attack on January 12, 1991 at the age of seventy-two. Professor Goldie\u27s death deprives the world\u27s legal community of one of its most outstanding scholars and is a grievous personal loss to his students and colleagues at the Syracuse University College of Law. Professor Goldie specialized in teaching the international law of the sea, international environmental and resources law, boundaries and zones, and treaties under the United States Constitution

Fusion of competing features is not serial

How features of an object are bound into a unique percept is one of the puzzling problems in the cognitive and neuro-sciences. In order to investigate the spatio-temporal mechanisms of feature binding, we serially present two verniers with opposite offset directions for very short durations. Only one vernier is perceived with its offset dominated by the vernier presented second. This dominance reverses if the two verniers are followed by masking gratings, i.e. the first presented vernier dominates performance. Therefore, feature fusion can neither be explained completely by spatially local mechanisms nor by the temporal order of appearance of elements

Grouping in the shine-through effect

How the elements of a visual scene are grouped into objects is one of the most fundamental but still poorly understood questions in visual neuroscience. Most investigations of perceptual grouping focus on static stimuli, neglecting temporal aspects. Using a masking paradigm, we show that the neural mechanisms underlying grouping seem to be both fast and complex. For example, a vernier target was followed by, first, a briefly presented grating and, then, a long-lasting, extended grating. Under these conditions, the briefly presented grating is hardly visible. Still, vernier discrimination strongly changed with the number of elements of the briefly displayed grating being worst for small gratings. In accordance with a neural network model of masking, we propose that the edges of the briefly presented grating and the vernier interfere in spite of the short presentation time. We suggest that this fast edge processing is a first step for unconscious grouping processe

Arginine methylation of the B cell antigen receptor promotes differentiation

Signals processed through the B cell antigen receptor (BCR) control both the proliferation and differentiation of B lymphocytes. How these different signaling modes are established at the BCR is poorly understood. We show that a conserved arginine in the tail sequence of the Igα subunit of the BCR is methylated by the protein arginine methyltransferase 1. This modification negatively regulates the calcium and PI-3 kinase pathways of the BCR while promoting signals leading to B cell differentiation. Thus, Igα arginine methylation can play an important role in specifying the outcome of BCR signaling

Grouping in the shine-through effect

How the elements of a visual scene are grouped into objects is one of the most fundamental but still poorly understood questions in visual neuroscience. Most investigations of perceptual grouping focus on static stimuli, neglecting temporal aspects. Using a masking paradigm, we show that the neural mechanisms underlying grouping seem to be both fast and complex. For example, a vernier target was followed by, first, a briefly presented grating and, then, a long-lasting, extended grating. Under these conditions, the briefly presented grating is hardly visible. Still, vernier discrimination strongly changed with the number of elements of the briefly displayed grating being worst for small gratings. In accordance with a neural network model of masking, we propose that the edges of the briefly presented grating and the vernier interfere in spite of the short presentation time. We suggest that this fast edge processing is a first step for unconscious grouping processes

The SARS-coronavirus-host interactome

Coronaviruses (CoVs) are important human and animal pathogens that induce fatal respiratory, gastrointestinal and neurological disease. The outbreak of the severe acute respiratory syndrome (SARS) in 2002/2003 has demonstrated human vulnerability to (Coronavirus) CoV epidemics. Neither vaccines nor therapeutics are available against human and animal CoVs. Knowledge of host cell proteins that take part in pivotal virus-host interactions could define broad-spectrum antiviral targets. In this study, we used a systems biology approach employing a genome-wide yeast-two hybrid interaction screen to identify immunopilins (PPIA, PPIB, PPIH, PPIG, FKBP1A, FKBP1B) as interaction partners of the CoV non-structural protein 1 (Nsp1). These molecules modulate the Calcineurin/NFAT pathway that plays an important role in immune cell activation. Overexpression of NSP1 and infection with live SARS-CoV strongly increased signalling through the Calcineurin/NFAT pathway and enhanced the induction of interleukin 2, compatible with late-stage immunopathogenicity and long-term cytokine dysregulation as observed in severe SARS cases. Conversely, inhibition of cyclophilins by cyclosporine A (CspA) blocked the replication of CoVs of all genera, including SARS-CoV, human CoV-229E and -NL-63, feline CoV, as well as avian infectious bronchitis virus. Non-immunosuppressive derivatives of CspA might serve as broad-range CoV inhibitors applicable against emerging CoVs as well as ubiquitous pathogens of humans and livestock