Cultural Vitality in Communities: Interpretation and Indicators

This report introduces a definition of cultural vitality that includes the range of cultural activity people around the country find significant. We use this definition as a lens to clarify our understanding of data necessary, as well as the more limited data currently available, to document arts and culture in communities in a consistent, recurrent and reliable manner. Specifically, we define cultural vitality as evidence of creating, disseminating, validating, and supporting arts and culture as a dimension of everyday life in communities. We develop and recommend an initial set of arts and culture indicators derived from nationally available data, and compare selected metropolitan areas based on these measures. Policy and planning implications for use of the cultural vitality definition and related measures are discussed

Arts and Culture in Communities: A Framework for Measurement

Offers a framework for capturing and measuring arts, culture, and creative expression at the neighborhood level. Discusses the presence of opportunities for cultural participation, impacts of participation, and support systems for cultural expression

Arts and Culture in Communities: Systems of Support

Presents findings by the Urban Institute's Arts and Culture Indicators in Community Building Project on the characteristics of support systems that are most likely to produce opportunities for cultural engagement

Arts and Culture in Communities: Unpacking Participation

Presents findings by the Urban Institute's Arts and Culture Indicators in Community Building Project on a range of arts and cultural participation within the context of various community building processes

Inhibition of hepatitis C virus internal ribosome entry site-mediated translation by an RNA targeting the conserved IIIf domain

Hepatitis C virus (HCV) translation initiation depends on an internal ribosome entry site (IRES). We previously identified an RNA molecule (HH363–10) able to bind and cleave the HCV IRES region. This paper characterizes its capacity to interfere with IRES function. Inhibition assays showed that it blocks IRES activity both in vitro and in a human hepatoma cell line. Although nucleotides involved in binding and cleavage reside in separate regions of the inhibitor HH363–10, further analysis demonstrated the strongest effect to be an intrinsic feature of the entire molecule; the abolishment of either of the two activities resulted in a reduction in its function. Probing assays demonstrate that HH363–10 specifically interacts with the conserved IIIf domain of the pseudoknot structure in the IRES, leading to the inhibition of the formation of translationally competent 80S particles. The combination of two inhibitory activities targeting different sequences in a chimeric molecule may be a good strategy to avoid the emergence of resistant viral variants.This work was supported by grant BFU2006-02568 from the Spanish Ministerio de Educación y Ciencia and CTS-233 from the Junta de Andalucía to A. B-H C. R-L was funder by grant BMC2003-669. R. D-G was the recipient of a fellowship from the Spanish Ministerio de Educación y CienciaPeer reviewe

Investing in Creativity: A Study of the Support Structure for U.S. Artists

Documents and analyzes the environment of support for individual artists. Provides a framework for analysis of various dimensions of the support structure, nationally and in specific sites across the U.S. Includes support programs and policy initiatives

Prevalence of multiple sclerosis in Valladolid, northern Spain

Producción CientíficaThe aim of this study was to ascertain the prevalence of multiple sclerosis (MS) in a northern Spanish region and to compare it with that from the most recent epidemiological studies in the country. MS prevalence was studied for a period of 2 years using multiple sources of information in the province of Valladolid, with a sample comprising a total population of 92,632. Patients were classified according to the Poser criteria. The crude prevalence of definite and probable MS was 58.3 per 100,000 (95% confidence interval: 43.7–75.7). The same methods have been used in ascertaining similar prevalence rates in Vélez-Málaga, Osona, and Gijón and a slightly lower rate in Teruel. Our survey confirms Spain as a high-risk area for MS, with prevalence rates over 50 per 100,00

Subtypes of Severely Mentally Ill Violent Offenders in a Spanish Forensic Psychiatric Hospital

Conduct disorder (CD) prior to age 15 identifies a subgroup of men with severe mental illness (SMI) who present a high risk for violence that persists across the life span. The present study examined male violent offenders with SMI in a forensic hospital in Spain, comparing those with SMI+CD and those without SMI-CD on the HCR-20 and PCL:SV. Violent offenders with SMI+CD obtained higher HCR-20 and PCL: SV total scores, and much higher H and factor 2 scores as compared to those without prior CD. Men with SMI+CD present a challenge to forensic psychiatric services

Highly solvatochromic and tunable fluorophores based on a 4,5-quinolimide scaffold: Novel CDK5 probes

Novel 4,5-quinolimide-based fluorophores are more solvatochromic and red-shifted than known naphthalimide analogues. Conjugation of one of these fluorophores to a peptide derived from CDK5 kinase demonstrated its sensitivity for monitoring the interaction with its regulatory partner p25. Introduction of the quinolimide-labelled peptide into living glioblastoma cells probed the interaction with endogenous p25.The work was supported by the Spanish Ministerio de Economía y Competividad grant SAF2012-32209 and the CSIC grant 2012280E096. J. A. G.-V. held a JAEdoc research contract from the CSIC and now is supported by a Marie-Curie fellowship EC-FP7 Framework (PIEF-GA-2013-623151). The work was also supported by the CNRS and a grant from Canceropole GSO 2015-E03 to MCM and has benefited from the facilities and expertise of the Montpellier RIO imaging facility (www.mri.cnrs.fr) at the Centre de Recherches en Biochimie Macromoléculaire, MontpellierPeer Reviewe

Smart lanthanide antennas for sensing water

Two new families of lanthanide antennas are described. 8-Methoxy- 4,5-dihydrocyclopenta[de]quinolin-2(1H)-one phosphonates or carboxylates behave as selective antennas exhibiting Eu3+ luminescence in organic solvents, while quinolin-2(1H)-one analogues selectively sensitize the Tb3+ emission. These emissions are quenched by H2O addition. Based on this behaviour, the new lanthanide antennas can be used as highly sensitive water sensors.Spanish Ministerio de Economia y Competividad SAF2012-32209 FU2015-67284-RMinisterio de Ciencia e Innovacion/Agencia Estatal de Investigacion/European Regional Development Fund CTQ2017-85658-R CTQ2015-63997-C2Consejo Superior de Investigaciones Cientificas (CSIC) 201580E07