6 research outputs found
Differences in the Use and Opinions About New eHealth Technologies Among Patients With Psychosis: Structured Questionnaire
[EN] Background: Despite a growing interest in the use of technology in order to support the treatment of psychotic disorders, limited
knowledge exists about the viability and acceptability of these eHealth interventions in relation to the clinical characteristics of
patients.
Objective: The objective of this study was to assess the access and use of, as well as experiences and interest in, new technologies
using a survey of patients diagnosed with early psychosis compared with a survey of patients diagnosed with chronic psychotic
disorders.
Methods: We designed a structured questionnaire. This questionnaire was divided into five parts: (1) clinical and demographic
information, (2) access and use of the internet, (3) use of the internet in relation to mental health, (4) experiences with technology,
and (5) patients¿ interest in eHealth services. In total, 105 patients were recruited from early psychosis units (n=65) and recovery
units (n=40).
Results: In this study, 84.8% (89/105) of the patients had access to the internet and 88.6% (93/105) owned an electronic internet
device. In total, 71.3% (57/80) of patients who owned a mobile phone were interested in eHealth systems and 38.2% (37/97)
reported negative experiences related to the internet usage. We observed differences between the groups in terms of device
ownership (P=.02), the frequency of internet access (P<.001), the use of social media (P=.01), and seeking health information
(P=.04); the differences were found to be higher in the early psychosis group. No differences were found between the groups in
terms of the use of internet in relation to mental health, experiences and opinions about the internet, or interest in eHealth
interventions (P=.43).
Conclusions: The availability and use of technology for the participants in our survey were equivalent to those for the general
population. The differences found between the groups in relation to the access or use of technology seemed to due to age-related
factors. The use of technology involving mental health and the interest in eHealth interventions were mainly positive and equivalent between the groups. Accordingly, this group of patients is a potential target for the emerging eHealth interventions, regardless
of their clinical status. However, 28.7% (23/80) of the studied patients rejected the use of internet interventions and 38.2% (37/97)
had unpleasant experiences related to its usage; thus, more in-depth studies are needed to better define the profile of patients with
psychosis who may benefit from eHealth treatments.This study was supported by Generalitat Valenciana (PROMETEO/2016/082 grant) and CIBERSAM and Fondo de Investigacion Sanitaria (PI01399, PI13/00447; PI17/00402, Cofunded FEDER).Bonet, L.; Llácer, B.; Hernandez-Viadel, M.; Arce Grilo, AD.; Blanquer Espert, I.; Cañete, C.; EscartÃ, MJ.... (2018). Differences in the Use and Opinions About New eHealth Technologies Among Patients With Psychosis: Structured Questionnaire. JMIR Mental Health. 5(3):1-12. https://doi.org/10.2196/mental.9950S11253Perkins, D. O., Gu, H., Boteva, K., & Lieberman, J. A. (2005). Relationship Between Duration of Untreated Psychosis and Outcome in First-Episode Schizophrenia: A Critical Review and Meta-Analysis. American Journal of Psychiatry, 162(10), 1785-1804. doi:10.1176/appi.ajp.162.10.1785Marshall, M., & Rathbone, J. (2011). Early intervention for psychosis. Cochrane Database of Systematic Reviews. doi:10.1002/14651858.cd004718.pub3Amos, A. (2012). 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A Proteomics Approach To Quantify Protein Levels Following RNA Interference:Case Study with Glutathione Transferase Superfamily from the Model Metazoan Caenorhabditis elegans
Loss-of-function phenotypic analysis via interference RNA (RNAi) technology is a revolutionary approach to assigning gene function. While transcript-based methodologies commonly validate RNAi gene suppression investigations, protein-based validation is less developed. This report illustrates the potential for two-dimensional sodium dodecyl sulfate polyacrylamide gel electrophoresis (2-DE) and gel analysis to quantify protein levels following RNAi. This case study involves three glutathione transferase (GST) genes targeted by RNAi from the model organism Caenorhabditis elegans
In vivo exposure to carbon monoxide induces delayed soluble guanylate cyclase activation by nitric oxide in rat brain cortex and cerebellum
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Lymphocyte cytochrome c oxidase, cyclic GMP and cholinergic muscarinic receptors as peripheral indicators of carbon monoxide neurotoxicity after acute and repeated exposure in the rat
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Extracellular cGMP Modulates Learning Biphasically by Modulating Glycine Receptors, CaMKII and Glutamate-Nitric Oxide-cGMP Pathway
It has been proposed that extracellular cGMP modulates the ability to learn a Y maze task, but the underlying mechanisms remained unknown. Here we show that extracellular cGMP, at physiological concentrations, modulates learning in the Y maze in a biphasic way by modulating the glutamate-nitric oxide-cGMP pathway in cerebellum. Extracellular cGMP reduces glycine receptors activation inducing a voltage-dependent calcium-channels-mediated increase of calcium in Purkinje neurons. This calcium increase modulates CaMKII phosphorylation in a biphasic way. When basal calcium concentration is low extracellular cGMP reduces CaMKII phosphorylation, increasing nitric oxide synthase activity, the glutamate-NO-cGMP pathway function and learning ability. When basal calcium is normal extracellular cGMP increases CaMKII phosphorylation, reducing nitric oxide synthase activity, the pathway function and learning. These data unveil new mechanisms modulating learning in the Y maze and likely other learning types which may be therapeutic targets to improve learning in pathological situations associated with altered cGMP levels