Study of the Start-Up Ecosystem in Lima, Peru: Analysis of Interorganizational Networks

According to the literature, In the context of changes at a global level the formation of new businesses drives the economy, being important start-ups, which are linked to a community of entrepreneurs, mentors, incubators, accelerators, providers of common services, angel investors, venture capitalists, universities and public support entities, which together configure an ecosystem that is linked to other ecosystems. In this way, this work focuses on the Lima, Peru ecosystem with the aim of providing an understanding of the interorganizational networks that are established based on the analysis of the interactions that occur in the LinkedIn social network. Definitions, methodology, results and conclusions are presented

Non-centralized environment to monitor and dynamically con gure highly distributed systems

Estudi i desenvolupament d'una plataforma orientada a sistemes distribuïts per a l'avaluació del rendiment d'aplicacions que s'executen en aquests entorns de grans requeriments de transferència d'informació, com és el cas més clar en les aplicacions de gestió de placement

Peces Fuera del Agua

[ES] En este trabajo académico llevaré a cabo un proyecto teórico-práctico que consiste en la realización de un cómic, desde la concepción de la idea hasta su realización. En el proceso se explorarán las fases por las que pasa la creación de un cómic, el diseño de personajes, la historia, distribución de viñetas, etc. La historia trata sobre una expedición por parte de animales marinos a la superficie terrestre. La trama sucede en un futuro lejano donde no existen los seres humanos y algunas especies marinas han avanzado lo suficiente como para desarrollar tecnología avanzada. Con equipamiento futurista, los seres subacuáticos serán capaces de llevar a cabo una expedición a tierra firme. Los temas principales del argumento serán los conflictos internos de los personajes, la lucha constante con el medio hostil y la exploración de un mundo de ciencia ficción a la vez maravilloso y triste.[EN] In this project I will develop a theoretical and practical work consisting of the creation of a comic book, since the inception of the idea to its realization. In the process I will explore the different phases involved in the creation of a comic book: character design, the plot, picture arrangement, etc. The story is about an expedition carried out by marine animals to the terrestrial surface. The plot happens in a far-future where human beings no longer exist and some marine species have developed to the point of being able to invent advanced technology. With futuristic equipment, the subaquatic beings will be able to make an on-land expedition. The main themes will be the internal conflicts of the characters, the constant fight against a hostile environment and the exploration of a sci-fi world both wonderful and sad.Cabrera Hernandez, D. (2021). Peces Fuera del Agua. Universitat Politècnica de València. http://hdl.handle.net/10251/170408TFG

Phagocytic and pinocytic uptake of cholesterol in Tetrahymena thermophila impact differently on gene regulation for sterol homeostasis

The ciliate Tetrahymena thermophila can either synthesize tetrahymanol or when available, assimilate and modify sterols from its diet. This metabolic shift is mainly driven by transcriptional regulation of genes for tetrahymanol synthesis (TS) and sterol bioconversion (SB). The mechanistic details of sterol uptake, intracellular trafficking and the associated gene expression changes are unknown. By following cholesterol incorporation over time in a conditional phagocytosis-deficient mutant, we found that although phagocytosis is the main sterol intake route, a secondary endocytic pathway exists. Different expression patterns for TS and SB genes were associated with these entry mechanisms. Squalene synthase was down-regulated by a massive cholesterol intake only attainable by phagocytosis-proficient cells, whereas C22-sterol desaturase required ten times less cholesterol and was up-regulated in both wild-type and mutant cells. These patterns are suggestive of at least two different signaling pathways. Sterol trafficking beyond phagosomes and esterification was impaired by the NPC1 inhibitor U18666A. NPC1 is a protein that mediates cholesterol export from late endosomes/lysosomes in mammalian cells. U18666A also produced a delay in the transcriptional response to cholesterol, suggesting that the regulatory signals are triggered between lysosomes and the endoplasmic reticulum. These findings could hint at partial conservation of sterol homeostasis between eukaryote lineages.Fil: Hernandez, Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFil: Gabrielli, Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFil: Costa, Joaquin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFil: Uttaro, Antonio Domingo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentin

LSE-IMF joint workshop social protection in a changing world

This is a summary report of 'Social Protection in a Changing World' - a workshop jointly sponsored by the LSE and IMF and held at the London School of Economics in November 2018. As part of its strategic focus, the LSE is putting a high priority on research related to the contours of new welfare provision. At the same time, the IMF is re-assessing the nature and extent of its engagement on social spending policies. In Spring 2019, the IMF will present a paper setting out a new strategic framework for engaging on these issues with its member countries to its Executive Board. This is being guided by a growing awareness that social spending is important for inclusive and sustainable economic growth and financial stability, the key focus of the IMF. Reflecting this convergence of interests, LSE and IMF jointly sponsored a workshop on 'Social Protection in a Changing World'. The workshop convened leading academics working in the field together with representatives from the IMF and the World Bank. The agenda for the day included discussions on emerging challenges, the role and design of social assistance and social insurance, the balance between universalism and targeting, and financing social protection

Humoral and cellular response in convalescent COVID-19 lupus patients

Systemic lupus erythematosus; Translational immunologyLupus eritematós sistèmic; Immunologia translacionalLupus eritematoso sistémico; Inmunología traslacionalIn SLE, underlying immune dysregulation and immunosuppression may increase the susceptibility to COVID-19 and impair the humoral and adaptive response. We aimed to characterize COVID-19 infection, identifying susceptibility and severity risk factors, assessing the presence of SARS-CoV-2 IgG antibodies and analyzing the cellular response. We established a prospective cohort of lupus patients to estimate the COVID-19 incidence compared to the reference general population. Data were collected via telephone interviews and medical record review. SARS-CoV-2 IgG antibodies were measured cross-sectionally as part of routine surveillance. Longitudinal changes in antibody titers and immunological profile from convalescent COVID-19 patients were evaluated at 6, 12 and 24 week after symptom onset. From immunological studies, PBMCs from convalescent patients were extracted and analyzed by flow cytometry and gene expression analysis. We included 725 patients, identifying 29 with PCR-confirmed COVID-19 infection and 16 with COVID-19-like symptoms without PCR-testing. Of the 29 confirmed cases, 7 had severe disease, 8 required hospital admission (27.6%), 4 intensive care, and 1 died. COVID-19 accumulated incidence was higher in lupus patients. Health care workers and anti-SSA/Ro52 antibody positivity were risk factors for COVID-19 susceptibility, and hypocomplementemia for severity. SARS-CoV-2 IgG antibodies were detected in 8.33% of patients. Three fourths of confirmed COVID-19 cases developed antibodies. High prednisone doses were associated with lack of antibody response. Antibody titers declined over time (39%). Convalescent patients at week 12 after symptom onset displayed a CD8+T cell reduction and predominant Th17 with a mild Th2 response, more pronounced in severe COVID-19 disease. Longitudinal immune response analysis showed a progressive sustained increase in CD8+ T and B memory cells with a decrease of Th17 signaling. Lupus patients are at higher risk of COVID-19 infection and new susceptibility and severity risk factors were identified. Lupus patients were able to mount humoral and cellular responses despite immunosuppressive therapy

CLEAR EVIDENCE FOR THE PRESENCE OF SECOND-GENERATION ASYMPTOTIC GIANT BRANCH STARS IN METAL-POOR GALACTIC GLOBULAR CLUSTERS

Galactic globular clusters (GCs) are known to host multiple stellar populations: a first generation (FG) with a chemical pattern typical of halo field stars and a second generation (SG) enriched in Na and Al and depleted in O and Mg. Both stellar generations are found at different evolutionary stages (e.g., the main-sequence turnoff, the subgiant branch, and the red giant branch (RGB)). The non detection of SG asymptotic giant branch (AGB) stars in several metal-poor ([Fe/H] < −1) GCs suggests that not all SG stars ascend the AGB phase, and that failed AGB stars may be very common in metal-poor GCs. This observation represents a serious problem for stellar evolution and GC formation/evolution theories. We report fourteen SG-AGB stars in four metal-poor GCs (M13, M5, M3, and M2) with different observational properties: horizontal branch (HB) morphology, metallicity, and age. By combining the H-band Al abundances obtained by the Apache Point Observatory Galactic Evolution Experiment survey with ground-based optical photometry, we identify SG Al-rich AGB stars in these four GCs and show that Al-rich RGB/AGB GC stars should be Na-rich. Our observations provide strong support for present, standard stellar models, i.e., without including a strong mass-loss efficiency, for low-mass HB stars. In fact, current empirical evidence is in agreement with the predicted distribution of FG and and SG stars during the He-burning stages based on these standard stellar models