I see what you mean

The ability to understand and predict others' behavior is essential for successful interactions. When making predictions about what other humans will do, we treat them as intentional systems and adopt the intentional stance, i.e., refer to their mental states such as desires and intentions. In the present experiments, we investigated whether the mere belief that the observed agent is an intentional system influences basic social attention mechanisms. We presented pictures of a human and a robot face in a gaze cuing paradigm and manipulated the likelihood of adopting the intentional stance by instruction: in some conditions, participants were told that they were observing a human or a robot, in others, that they were observing a human-like mannequin or a robot whose eyes were controlled by a human. In conditions in which participants were made to believe they were observing human behavior (intentional stance likely) gaze cuing effects were significantly larger as compared to conditions when adopting the intentional stance was less likely. This effect was independent of whether a human or a robot face was presented. Therefore, we conclude that adopting the intentional stance when observing others' behavior fundamentally influences basic mechanisms of social attention. The present results provide striking evidence that high-level cognitive processes, such as beliefs, modulate bottom-up mechanisms of attentional selection in a top-down manner

Coulomb Charging at Large Conduction

We discuss the suppression of Coulomb charging effects on a small metallic island coupled to an electrode by a tunnel junction. At high temperatures the quantum corrections to the classical charging energy $E_c=e^2/2C$, where $C$ is the island capacitance, are evaluated. At low temperatures the large quantum fluctuations of the island charge cause a strong reduction of the effective $E_c$ which is determined explicitly in the limit of a large tunneling conductance.Comment: 4 page

From Needs to Actions to Secure Apps?:The Effect of Requirements and Developer Practices on App Security

Increasingly mobile device users are being hurt by security or privacy issues with the apps they use. App developers can help prevent this; inexpensive security assurance techniques to do so are now well established, but do developers use them? And if they do so, is that reflected in more secure apps? From a survey of 335 successful app developers, we conclude that less than a quarter of such professionals have access to security experts; that less than a third use assurance techniques regularly; and that few have made more than cosmetic changes as a result of the European GDPR legislation. Reassuringly, we found that app developers tend to use more assurance techniques and make more frequent security updates when (1) they see more need for security, and (2) there is security expert or champion involvement

Lossless, Persisted Summarization of Static Callgraph, Points-To and Data-Flow Analysis

Static analysis is used to automatically detect bugs and security breaches, and aids compiler optimization. Whole-program analysis (WPA) can yield high precision, however causes long analysis times and thus does not match common software-development workflows, making it often impractical to use for large, real-world applications. This paper thus presents the design and implementation of ModAlyzer, a novel static-analysis approach that aims at accelerating whole-program analysis by making the analysis modular and compositional. It shows how to compute lossless, persisted summaries for callgraph, points-to and data-flow information, and it reports under which circumstances this function-level compositional analysis outperforms WPA. We implemented ModAlyzer as an extension to LLVM and PhASAR, and applied it to 12 real-world C and C++ applications. At analysis time, ModAlyzer modularly and losslessly summarizes the analysis effect of the library code those applications share, hence avoiding its repeated re-analysis. The experimental results show that the reuse of these summaries can save, on average, 72% of analysis time over WPA. Moreover, because it is lossless, the module-wise analysis fully retains precision and recall. Surprisingly, as our results show, it sometimes even yields precision superior to WPA. The initial summary generation, on average, takes about 3.67 times as long as WPA

Vitamin D status and epigenetic-based mortality risk score: strong independent and joint prediction of all-cause mortality in a population-based cohort study

Background: Vitamin D deficiency and insufficiency have been established to be strongly associated with increased overall mortality and deaths from specific aging-related diseases. Recently, an epigenetic “mortality risk score” (MS) based on whole blood DNA methylation at the 10 most prominent mortality-related cytosine-phosphate-guanine (CpG) sites has also been found to be highly related to all-cause mortality. This study aimed to explore whether vitamin D status, defined by serum 25-hydroxyvitamin D [25(OH)D] concentrations, is associated with the MS and to what extent both indicators are individually and jointly capable of predicting all-cause mortality in a general population sample of older adults. Results: The MS was derived from the blood DNA methylation profiles measured by Illumina Human Methylation 450K Beadchip, and serum 25(OH)D concentration was measured among 1467 participants aged 50–75 of the German ESTHER cohort study. There was no association between vitamin D status and the MS at baseline, but both metrics were prominently and independently associated with all-cause mortality during a median follow-up of 15.2 years. The combination of both indicators showed the potential to be a particularly strong prognostic index for all-cause mortality. Participants with vitamin D deficiency (< 30 nmol/L) and high MS (> 5 CpG sites with aberrant methylation) had almost sixfold mortality (hazard ratio 5.79, 95% CI 3.06–10.94) compared with participants with sufficient vitamin D (≥ 50 nmol/L) and a low MS (0–1 CpG site with aberrant methylation). Conclusions: This study suggests that vitamin D and the MS are strong independent predictors of all-cause mortality in older adults

Finite key analysis for symmetric attacks in quantum key distribution

We introduce a constructive method to calculate the achievable secret key rate for a generic class of quantum key distribution protocols, when only a finite number n of signals is given. Our approach is applicable to all scenarios in which the quantum state shared by Alice and Bob is known. In particular, we consider the six state protocol with symmetric eavesdropping attacks, and show that for a small number of signals, i.e. below the order of 10^4, the finite key rate differs significantly from the asymptotic value for n approaching infinity. However, for larger n, a good approximation of the asymptotic value is found. We also study secret key rates for protocols using higher-dimensional quantum systems.Comment: 9 pages, 5 figure

Regulation of Cell Number by MAPK-Dependent Control of Apoptosis A Mechanism for Trophic Survival Signaling

AbstractTrophic mechanisms in which neighboring cells mutually control their survival by secreting extracellular factors play an important role in determining cell number. However, how trophic signaling suppresses cell death is still poorly understood. We now show that the survival of a subset of midline glia cells in Drosophila depends upon direct suppression of the proapoptotic protein HID via the EGF receptor/RAS/MAPK pathway. The TGFα-like ligand SPITZ is activated in the neurons, and glial cells compete for limited amounts of secreted SPITZ to survive. In midline glia that fail to activate the EGFR pathway, HID induces apoptosis by blocking a caspase inhibitor, Diap1. Therefore, a direct pathway linking a specific extracellular survival factor with a caspase-based death program has been established

Crowdsourcing the State of the Art(ifacts)

In any field, finding the "leading edge" of research is an on-going challenge. Researchers cannot appease reviewers and educators cannot teach to the leading edge of their field if no one agrees on what is the state-of-the-art. Using a novel crowdsourced "reuse graph" approach, we propose here a new method to learn this state-of-the-art. Our reuse graphs are less effort to build and verify than other community monitoring methods (e.g. artifact tracks or citation-based searches). Based on a study of 170 papers from software engineering (SE) conferences in 2020, we have found over 1,600 instances of reuse; i.e., reuse is rampant in SE research. Prior pessimism about a lack of reuse in SE research may have been a result of using the wrong methods to measure the wrong things.Comment: Submitted to Communications AC

Longitudinal Associations of Body Mass Index, Waist Circumference, and Waist-to-Hip Ratio with Biomarkers of Oxidative Stress in Older Adults: Results of a Large Cohort Study

Background: In the literature, obesity is discussed as a determinant of high oxidative stress (OS). Hence, prevention or reduction of obesity could prevent high OS and subsequently serve as a target for “healthy aging.” Methods: Diacron’s reactive oxygen metabolites test (D-ROM) and total thiol levels (TTL), a marker of antioxidant defense capacity, were measured in 1,734 participants of a population-based cohort study of older adults (age range: 57–83 years) at 2 time points 3 years apart. The longitudinal associations of body mass index, waist-to-hip ratio, and waist circumference with D-ROM and TTL were assessed with multivariable adjusted generalized linear models. Dose-response analyses were conducted with restricted cubic splines. Results: D-ROM was not significantly associated with any of the weight measures. On the contrary, TTL showed statistically significant, inverse linear associations with all weight measures. Conclusion: A healthy body weight seems to be highly relevant for the antioxidative defense capacity of human beings. In contrast, D-ROM levels were independent of the study participant’s weight. Clinical trials are needed to corroborate if loss of weight by obese individuals can effectively increase TTL and subsequently also life expectancy