KEHAMILAN DENGAN SINDROMA ANTIFOSFOLIPID

Abstract Antiphospholipid antibody syndrome is disorder of coagulation characterize with vascular thrombosis associated with increase of antiphospholipid (aPL) antibody such as anticardiolipin (aCL) antibodies, lupus anticoagulant (LA), and anti-beta 2 glycoprotein I antibody. Management of with antiphospholipid antibody syndrome basicly consists of  management and pregnancy (antenatal care), labour, and puerpurium. The  aim of the management is to monitor the risk of thrombosis,  inadequate uteroplacenter circulation, and decide the perfect timing for delivery. The rational therapy given is both preventive and curative with anticoagulant and antiplatelet agent. The new paradigm in management of antiphospholipid antibody syndrome is treatment with intravena immunoglobulin to decrease aCL and LA.   Keyword: Pregnancy, Antiphospholipid syndrome   Abstrak Sindroma antifosfolipid merupakan suatu kelainan sistem pembekuan darah yang ditandai dengan trombosis vaskuler yang dihubungkan dengan peningkatan antibodi antifosfolipid (aPL) yaitu antibodi antikardiolipin (aCL), antikoagulan lupus (LA) dan antibodi anti-beta 2 glikoproteinI. Penatalaksanaan kehamilan dengan sindroma antifosfolipid pada dasarnya terdiri atas penatalaksanaan dalam kehamilan (pemeriksaan antenatal), persalinan dan masa nifas dengan tujuan pemantauan pada risiko trombosis, gangguan sirkulasi uteroplasenter dan penentuan saat persalinan yang adekuat. Terapi rasional yang diberikan adalah terapi preventif dan kuratif dengan pemberian antikoagulan dan antiagregasi trombosit. Paradigma baru dalam penatalaksanaan sindroma antifosfolipid adalah dengan pemberian terapi imunoglobulin intravena yang bertujuan menurunkan kadar antibodi antikardiolipid dan antikoagulan lupus.   Kata kunci: Kehamilan, Sindroma  antifosfolipi

PENGARUH DEBT RATIO, DIVIDEN PAY OUT RATIO, RETURN ON EQUITY, PERUMBUHAN LABA, UKURAN KORPORASI, DAN PERPUTARAN KAS OPERASI TERHADAP PER (Studi Di Korporasi Sektor Manufaktur yang Listing di Bursa Efek Indonesia Jangka Waktu 2009 – 2012)

The mean of this research is examine  influence  debt ratio, dividend payout ratio variable, return on equity variable, earnings growth, size, and operating cash flow on price earning ratio (PER) in finance and manufacturing companies in Indonesia Stock Exchange in the period of year 2009 to 2012. The population in this study is the company in the sector manufacturing listed on the Indonesia Stock Exchange period of year 2009 to 2012. Samples were taken by purposive sampling and obtained 45 companies in the manufacturing sector as sample. Linear Regression Analysis with Simultaneous Significance Test (F statistic Test) and Individual Parameter Significance Test (Test Statistic t) is an analytical technique used in this study. The results showed that the independent variables of the debt ratio variable, size together significantly influence the price earnings ratio (PER) in the financial sector companies in the BEI and the independent variables of the dividend payout ratio and earnings growth together significantly influence  price earnings ratio (PER) at manufacturing companies listed on BEI. These results support data obtained from the World Bank regarding Indonesia's economic growth in 2012 on the production side, manufacturing performance is quite strong. This increase was achieved by the relatively large performance  domestic sectors such as those in processed foodstuffs, processed various beverages and processed various tobacco products (increasing 10.4% year on year) as well as fertilizer yields, yields from chemicals and rubber products (increased by 15.4% from year to year)

Analisis penerapan sistem administrasi pencatatan laporan keuangan berbasis aplikasi keuangan smartphone pada UMKM di Tangerang Selatan

This research was conducted on MSME actors in South Tangerang by using a descriptive type of research. The type of data used is primary data. In addition, this study used a survey technique using a questionnaire. The data analysis used was PIECES analysis.The results of this study conclude that MSME actors in the South Tangerang Region need an easy, practical and efficient accounting record application. When compared with using PIECES analysis, the shortcomings and weaknesses contained in the old system or manual system can be overcome with a new system, namely a smartphone-based system. By implementing a good financial administration system and in accordance with standard accounting standards (SAK EMKM), it is easier for business actors to find out profit or loss in the specified period. Business actors can also automatically make financial reports that describe the financial performance of their business. If the performance is known, MSME actors can make plans and take strategic policies for business development and product development

ANALISIS PENERAPAN SISTEM ADMINISTRASI PENCATATAN LAPORAN KEUANGAN BERBASIS MS. EXCEL PADA UMKM DI TANGERANG SELATAN

The purpose of this study was to evaluate the use of Ms. Excel in recording financial transactions that produce financial reports of Micro, Small and Medium Enterprises (MSMEs) according to the SAK EMKM registered at the South Tangerang KUKM Cooperative Office with the type of basic food business. In this research, the method used is descriptive qualitative as well as conducting studies in accordance with the reality of the field to be able to see the application as well as evaluate the findings. The data used are primary and secondary data, namely data from the South Tangerang KUKM Cooperative Office and the results of interviews with business actors. Of the SMEs that are registered in the KUKM South Tangerang Cooperative, it is still found that they have not applied financial reports according to the SAK EMKM using Ms. Excel, because of the lack of understanding of the need for such recording. For those who have used Ms. Excel, has proven to make it easier to record business transactions and easy to record financial statements, although it is still not in accordance with SAK EMKM. Keywords : Administration, EMKM Financial Report, MS. Excel, Record keepin

PROCESS OF PROSPEROUS RESEARCH FILES IN THE CASE DETERMINING NEW INSTITUTIONS IN CRIMINAL MEASURES CORRUPTION

This thesis is the result of research on "Process Attorney Researcher Case file in Determine Suspect New on Corruption", specifically this thesis discusses the process of determining the new suspects by prosecutors investigators file corruption cases and factor inhibitors for Attorney Researcher Files Case to determine a suspect new in the case file corruption. In particular, this thesis examines several cases of corruption filed by Investigator Police Resort Arga Makmur District Attorney of Public Prosecutions to Arga Makmur. The results of the study illustrate that the Attorney Researcher in determining new suspects in the case files submitted by police investigators are using the instrument giving direct instructions by the prosecution team of researchers P 19 and the instrument exposes / his case subsequently prosecutors investigators case file gives instructions to the investigator to be fulfilled within 14 days after prosecutors clue investigators met by investigators, the case file is declared complete by prosecutors investigators (P21)

THE VARIATION OF THE NOS3 GENE RS1799983 IS NOT ASSOCIATED WITH PREECLAMPSIA IN MALAY POPULATION

ABSTRACT Background: eNOS play role in preeclampsia pathophysiology due to disturbing spiral arteries re-modelling and enhanced maternal vasoconstriction. A genetic variant of NOS3 associated with eNOS level. In addition, the previous study reported a genetic variant of NOS3 rs1799983 as a risk of preeclampsia with conflicting results beyond the population. To the best of our literature search, this genetic variant as preeclampsia risk has never been reported in the Jambi Malay population. This study aims to determine the association of the NOS3 genetic variant with preeclampsia in the Jambi Malay population. Methods: This study was a cross-sectional study that involved 43 pregnant women suffering preeclampsia and 53 normotensive pregnant women. All the subject resides in Jambi Province and was Jambi Malays. Genotyping was performed with tetra ARMS-PCR. Bivariate statistically analysis was performed. Result: The frequency of GT genotype was lower in the preeclamptic group and GG genotype was higher in the preeclamptic group than the TT genotype, but the difference was not statistically different for NOS3 rs1799983. Conclusion: Our findings indicate that the genetic variant of NOS3 rs1799983 is not associated with preeclampsia in the Jambi Malay population. Keywords: NOS3, eNOS, rs1799983, genetic variant, preeclampsia, Malay population   ABSTRAK Pendahuluan: eNOS berperan dalam patofisiologi preeklamsia karena mengganggu remodelling arteri spiralis dan meningkatkan vasokonstriksi maternal. Varian gen NOS3 berkaitan engan peningkatan kadar eNOS. Penelitian sebelumnya melaporkan hasil yang bertentangan pada berbagai populasi terkait hubungan antara varian gen NOS3 rs1799983 dengan risiko kejadian preeklamsia. Sejauh pencarian literatur, varian gen NOS3 rs1799983 sebagai risiko preeklamsia belum pernah dilaporkan pada populasi Melayu Jambi. Penelitian ini bertujuan mengetahui hubungan varian gen NOS3 dengan preeklamsia pada populasi Melayu Jambi. Metode: Penelitian ini menggunakan desain potong lintang, melibatkan 43 orang ibu hamil dengan preeklamsia dan 53 orang ibu hamil normotensif. Semua subjek berdomisili di Provinsi Jambi dan merupakan orang Melayu Jambi. Pemeriksaan genotip dilakukan dengan metode tetra ARMS-PCR. Analisis statistik dilakukan meggunakan uji bivariat. Hasil: Hasil analisis didapatkan frekuensi genotip GT lebih rendah pada kelompok preeklampsia dan genotip GG lebih tinggi pada kelompok preeklampsia dibandingkan genotip TT, namun perbedaan tersebut tidak berbeda bermakna secara statistik. Kesimpulan: Hasil penelitian ini mengesankan bahwa varian genetik NOS3 rs1799983 tidak meningkatkan risiko preeklampsia pada populasi Melayu Jambi. Kata kunci: NOS3, eNOS, rs1799983, varian genetik, preeklamsia, populasi Melay