Observation of two-wave structure in strongly nonlinear dissipative granular chains

In a strongly nonlinear viscous granular chain under conditions of loading that exclude stationary waves (e.g., impact by a single grain) we observe a pulse that consists of two interconnected but distinct parts. One is a leading narrow "primary pulse" with properties similar to a solitary wave in a "sonic vacuum." It arises from strong nonlinearity and discreteness in the absence of dissipation, but now decays due to viscosity. The other is a broad, much more persistent shock-like "secondary pulse" trailing the primary pulse and caused by viscous dissipation. The medium behind the primary pulse is transformed from a "sonic vacuum" to a medium with finite sound speed. When the rapidly decaying primary pulse dies, the secondary pulse continues to propagate in the "sonic vacuum," with an oscillatory front if the viscosity is relatively small, until its eventual (but very slow) disintegration. Beyond a critical viscosity there is no separation of the two pulses, and the dissipation and nonlinearity dominate the shock-like attenuating pulse which now exhibits a nonoscillatory front

Evolution of the Primary Pulse in 1D Granular Crystals Subject to On-Site Perturbations: Analytical Study

Propagation of primary pulse through an un-compressed granular chain subject to external on-site perturbation is studied. Analytical procedure predicting the evolution of the primary pulse is devised for the general form of the on-site perturbation applied on the chain. The validity of the analytical model is confirmed with several specific granular setups such as, chains mounted on the nonlinear elastic foundation, chains perturbed by the dissipative forces as well as randomly perturbed chains. Additional interesting finding made in the present study corresponds to the chains subject to a special type of perturbations including the terms leading to dissipation and those acting as an energy source. It is shown in the study that application of such perturbation may lead to formation of stable stationary shocks acting as attractors for the initially unperturbed, propagating Nesterenko solitary waves. Interestingly enough the developed analytical procedure provides an extremely close estimations for the amplitudes of these stationary shocks as well as predicts zones of their stability. In conclusion we would like to stress that the developed analytical model have demonstrated spectacular correspondence to the results of direct numerical simulations for all the setups considered in the study

Short Pulse Dynamics in Strongly Nonlinear Dissipative Granular Chains

We study the energy decay properties of a pulse propagating in a strongly nonlinear granular chain with damping proportional to the relative velocity of the grains. We observe a wave disturbance that at low viscosities consists of two parts exhibiting two entirely different time scales of dissipation. One part is an attenuating solitary wave, is dominated by discreteness and nonlinearity effects as in a dissipationless chain, and has the shorter lifetime. The other is a purely dissipative shocklike structure with a much longer lifetime and exists only in the presence of dissipation. The range of viscosities and initial configurations that lead to this complex wave disturbance are explored

A cardinal role for cathepsin D in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci

The bactericidal function of macrophages against pneumococci is enhanced by their apoptotic demise, which is controlled by the anti-apoptotic protein Mcl-1. Here, we show that lysosomal membrane permeabilization (LMP) and cytosolic translocation of activated cathepsin D occur prior to activation of a mitochondrial pathway of macrophage apoptosis. Pharmacological inhibition or knockout of cathepsin D during pneumococcal infection blocked macrophage apoptosis. As a result of cathepsin D activation, Mcl-1 interacted with its ubiquitin ligase Mule and expression declined. Inhibition of cathepsin D had no effect on early bacterial killing but inhibited the late phase of apoptosis-associated killing of pneumococci in vitro. Mice bearing a cathepsin D-/- hematopoietic system demonstrated reduced macrophage apoptosis in vivo, with decreased clearance of pneumococci and enhanced recruitment of neutrophils to control pulmonary infection. These findings establish an unexpected role for a cathepsin D-mediated lysosomal pathway of apoptosis in pulmonary host defense and underscore the importance of apoptosis-associated microbial killing to macrophage function

Delegated job design

We develop a theory of delegation within organizations where agents are privately informed about whether they should be engaged in exploitation or in exploration activities. Excessive delegation lead agents to inefficiently herd into exploration in an attempt to boost their market value. The theory is consistent with both high-delegation practices and practices where agents are assigned to activities. Our main result is that an agent should be delegated more the weaker career concerns, a variable that is made endogenous through the firm's technology and its degree of transparency. The theory sheds light on empirical regularities that are previously unexplained, such as a positive relation between wages and delegation, and delegation being more prevalent in closed environments or environments with long-term employment contracts

The Challenges of Creativity in Software Organizations

Part 1: Creating ValueInternational audienceManaging creativity has proven to be one of the most important drivers in software development and use. The continuous changing market environment drives companies like Google, SAS Institute and LEGO to focus on creativity as an increasing necessity when competing through sustained innovations. However, creativity in the information systems (IS) environment is a challenge for most organizations that is primarily caused by not knowing how to strategize creative processes in relation to IS strategies, thus, causing companies to act ad hoc in their creative endeavors. In this paper, we address the organizational challenges of creativity in software organizations. Grounded in a previous literature review and a rigorous selection process, we identify and present a model of seven important factors for creativity in software organizations. From these factors, we identify 21 challenges that software organizations experience when embarking on creative endeavors and transfer them into a comprehensive framework. Using an interpretive research study, we further study the framework by analyzing how the challenges are integrated in 27 software organizations. Practitioners can use this study to gain a deeper understanding of creativity in their own business while researchers can use the framework to gain insight while conducting interpretive field studies of managing creativity

Historical Analysis: Tracking, Problematizing, and Reterritorializing Achievement and the Achievement Gap

For more than a century, state and federal governments and organizations have used different measures to determine if students and groups of students have achieved in a particular subject or grade level. While the construct of achievement is applied irrespective of student differences, this equal application turns out to be anything but equitable. In this chapter, we work to understand the way achievement plays out for Black students by deconstructing how the word achievement works. In doing so, we track the history of education, testing, and curriculum as it has been applied to Black youth and youth of color

The changing form of Antarctic biodiversity

Antarctic biodiversity is much more extensive, ecologically diverse and biogeographically structured than previously thought. Understanding of how this diversity is distributed in marine and terrestrial systems, the mechanisms underlying its spatial variation, and the significance of the microbiota is growing rapidly. Broadly recognizable drivers of diversity variation include energy availability and historical refugia. The impacts of local human activities and global environmental change nonetheless pose challenges to the current and future understanding of Antarctic biodiversity. Life in the Antarctic and the Southern Ocean is surprisingly rich, and as much at risk from environmental change as it is elsewher