10 research outputs found
Loss of integrity and atrophy in cingulate structural covariance networks in Parkinson's disease
Neuro Imaging Researc
Altered Whole-Brain and Network-Based Functional Connectivity in Parkinson's Disease
Neuro Imaging Researc
Diabetes en de gevolgen voor de hersenen: Een onderschat probleem
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Regional Structural Hippocampal Differences Between Dementia with Lewy Bodies and Parkinson's Disease
Neuro Imaging Researc
Age- and disease-related cerebral white matter changes in patients with Parkinson's disease
Neuro Imaging Researc
Cognitive performance, psychological well-being, and brain magnetic resonance imaging in older patients with type 1 diabetes
Item does not contain fulltextModest cognitive impairment has been reported in young-adult patients with type 1 diabetes. In older patients with type 2 diabetes, cognitive impairments are more pronounced, which might be due to age but also to differential effects of type 1 diabetes and type 2 diabetes on the brain. This study therefore assessed cognitive performance and magnetic resonance imaging (MRI) of the brain in older type 1 diabetic patients. Forty type 1 diabetic patients (age >50 years) and 40 age-matched control subjects were included. Neuropsychological assessment included all major cognitive domains, and psychological well-being was assessed with questionnaires. Atrophy, white-matter abnormalities, and infarcts were rated on MRI scans. Type 1 diabetic patients performed slightly (effect sizes <0.4) worse on cognitive tasks, but only "speed of information processing" reached statistical significance. No significant between-group differences were found on any of the MRI parameters. Type 1 diabetic patients tended to report more cognitive and depressive problems than control subjects, but this did not correlate with the performance on cognitive tests. We conclude that cognition in older type 1 diabetic patients is only mildly disturbed. Chronic exposure to hyperglycemia is in itself, even at older age, apparently not sufficient to have considerable impact on the brain.7 p
The use of insulin pump therapy in diabetes mellitus type 1 and its relation to cognitive performance, psychological well-being and brain MRI.
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Hippocampal body atrophy in mild Parkinson's disease
Neurological Motor Disorder