Perianal eccrine adenocarcinoma

<p>Abstract</p> <p>Background</p> <p>Eccrine carcinoma is a quite rare malignant tumor that typically arises from a normal sweat gland and that features a rather high recurrence rate subsequent to simple excision. Given its rather poor response to adjuvant therapy, wide excision of the lesion with tumor-free margins may offer a reasonable chance for long-term control of this neoplasm.</p> <p>Case presentation</p> <p>Herein, we report on an unusual case of perianal eccrine carcinoma, initially presenting as a perianal abscess.</p> <p>Conclusion</p> <p>Even though eccrine carcinomas would appear to be rare, when dealing with recurrent skin tumors or recurrent perianal fistulas, the possibility of eccrine carcinoma should be considered by consulting clinicians.</p

Rb-Sr and Sm-Nd dating of olivine-phyric shergottite Yamato 980459: Petrogenesis of depleted shergottites

Martian meteorite Yamato (Y) 980459 has undergone terrestrial weathering in Antarctica. The weathering has affected the Sm-Nd isotopic system. Acid-washed pyroxenes, whole rock and quenched glass samples define a Sm-Nd isochron age of 472±47 (±2σ) Ma and a high initial εNd value of +36.9±2.2 (±2σ). Both values are indisguishable from those reported for the other olivine-phyric depleted shergottite DaG 476. The Rb-Sr system of Y980459 shows even more terrestrial disturbance. The same acid-washed samples, which have a narrow Rb/Sr variation of only～10%, do not yield an Rb-Sr isochron. However, the weighted average of nine samples yields a good initial ^(87)Sr/^(86)Sr ratio value of 0.701384±0.000021 (±2σ) at 472Ma. This value is only slightly higher, by 1-2 ε-units, than that estimated from plagioclase data for DaG 476. Calculations for a two-stage model for Sr and Nd isotopic evolution indicate that Y980459 came from a depleted mantle reservoir with ^(147)Sm/^(144)Nd=～0.266 and ^(87)Rb/^(86)Sr=～0.04, similar to the DaG 476 source. A three-stage model calculation suggests that the REE abundances and Nd isotopic systematics of Y980459 could be produced by partial melting of high ^(147)Sm/^(144)Nd garnet-rich residues which were formed after the extraction of LREE-rich, nakhlite-like melts from a postulated garnet-clinopyroxene-olivine source having ^(147)Sm/^(144)Nd=～0.235

Constraints on Martian Differentiation Processes from Rb-Sr and Sm-Nd Isotopic Analyses of the Basaltic Shergottite QUE 94201

Isotopic analyses of mineral, leachate, and whole rock fractions from the Martian shergottite meteorite QUE 94201 yield Rb-Sr and Sm-Nd crystallization ages of 327 +/- 12 and 327 +/- 19 Ma, respectively. These ages are concordant, although the isochrons are defined by different fractions within the meteorite. Comparison of isotope dilution Sm and Nd data for the various QUE 94201 fractions with in situ ion microprobe data for QUE 94201 minerals from the literature demonstrate the presence of a leachable crustal component in the meteorite. This component is likely to have been added to QUE 94201 by secondary alteration processes on Mars, and can affect the isochrons by selectively altering the isotopic systematics of the leachates and some of the mineral fractions. The absence of crustal recycling processes on Mars may preserve the geochemical evidence for early differentiation and the decoupling of the Rb-Sr and Sm-Nd isotopic systems, underscoring one of the fundamental differences between geologic processes on Mars and the Earth

Rb-Sr, Sm-Nd and Ar-Ar isotopic systematics of Antarctic nakhlite Yamato 000593

sotopic analysis of the newly found Antarctic nakhlite Yamato (Y) 000593 yields a Rb-Sr age of 1.30±0.02Ga with an initial ^(87)Sr/^(86)Sr of 0.702525±0.000027, a Sm-Nd age of 1.31±0.03Ga with an initial ε_(Nd) of + 16.0±0.2 and an Ar-Ar isochron age of <=1.36Ga. The concordancy of these three ages and Rb-Sr and Sm-Nd initial isotopic signatures strongly suggest that Y000593 crystallized from low Rb/Sr, light REE-depleted source materials ～1.31Ga ago. The crystallization age of Y000593 is compared with the age data of non-Antarctic nakhlites (Nakhla, Governador Valadares, Lafayette and Northwest Africa 998) and Chassigny. The initial Sr and Nd isotopic signatures suggest that Lafayette and Y000593 were co-magmatic or at least came from very similar magmas. Cosmogenic ^(36)Ar concentrations in Y000593 resemble those in other nakhlites. The similarities in crystallization and ejection ages and in petrologic features suggest the nakhlites were derived from similar source regions, and launch pairing of nakhlites and Chassigny. The Rb-Sr data for Y000593 show that the isotopic system is disturbed by pre-terrestrial alteration of olivine. Although many of the acid-leached residues of mineral fractions fall along the 1.30Ga Rb-Sr isochron, leached olivine does not. This indicates the lack of isotopic equilibrium between the olivine fractions and the secondary alteration phases. A tie-line between two olivine leachates provides a calculated "age" of 650±80Ma with an initial ^(87)Sr/^(86)Sr of ～0.70465, which gives a hint for the isotopic signatures of local brine as well as the timing of an aqueous alteration event on the Martian surface

Differential Expression and Function of Nicotinic Acetylcholine Receptors in Subdivisions of Medial Habenula

Neuronal nAChRs in the medial habenula (MHb) to the interpeduncular nucleus (IPN) pathway are key mediators of nicotine's aversive properties. In this paper, we report new details regarding nAChR anatomical localization and function in MHb and IPN. A new group of knock-in mice were created that each expresses a single nAChR subunit fused to GFP, allowing high-resolution mapping. We find that α3 and β4 nAChR subunit levels are strong throughout the ventral MHb (MHbV). In contrast, α6, β2, β3, and α4 subunits are selectively found in some, but not all, areas of MHbV. All subunits were found in both ChAT-positive and ChAT-negative cells in MHbV. Next, we examined functional properties of neurons in the lateral and central part of MHbV (MHbVL and MHbVC) using brain slice patch-clamp recordings. MHbVL neurons were more excitable than MHbVC neurons, and they also responded more strongly to puffs of nicotine. In addition, we studied firing responses of MHbVL and MHbVC neurons in response to bath-applied nicotine. Cells in MHbVL, but not those in MHbVC, increased their firing substantially in response to 1 μm nicotine. Additionally, MHbVL neurons from mice that underwent withdrawal from chronic nicotine were less responsive to nicotine application compared with mice withdrawn from chronic saline. Last, we characterized rostral and dorsomedial IPN neurons that receive input from MHbVL axons. Together, our data provide new details regarding neurophysiology and nAChR localization and function in cells within the MHbV

Clinical Effectiveness, Access to, and Satisfaction with Care Using a Telehomecare Substitution Intervention: A Randomized Controlled Trial

Background. Hospitalization accounts for 70% of heart failure (HF) costs; readmission rates at 30 days are 24% and rise to 50% by 90 days. Agencies anticipate that telehomecare will provide the close monitoring necessary to prevent HF readmissions. Methods and Results. Randomized controlled trial to compare a telehomecare intervention for patients 55 and older following hospital discharge for HF to usual skilled home care. Primary endpoints were 30- and 60-day all-cause and HF readmission, hospital days, and time to readmission or death. Secondary outcomes were access to care, emergency department (ED) use, and satisfaction with care. All-cause readmissions at 30 days (16% versus 19%) and over six months (46% versus 52%) were lower in the telehomecare group but were not statistically significant. Access to care and satisfaction were significantly higher for the telehomecare patients, including the number of in-person visits and days in home care. Conclusions. Patient acceptance of the technology and current home care policies and processes of care were barriers to gaining clinical effectiveness and efficiency

Nuclear Transcriptomes of the Seven Neuronal Cell Types That Constitute the Drosophila Mushroom Bodies

The insect mushroom body (MB) is a conserved brain structure that plays key roles in a diverse array of behaviors. The Drosophila melanogaster MB is the primary invertebrate model of neural circuits related to memory formation and storage, and its development, morphology, wiring, and function has been extensively studied. MBs consist of intrinsic Kenyon Cells that are divided into three major neuron classes (gamma, alpha'/beta' and alpha/beta) and 7 cell subtypes (gammad, gammam, alpha'/beta'ap, alpha'/beta'm, alpha/betap, alpha/betas and alpha/betac) based on their birth order, morphology, and connectivity. These subtypes play distinct roles in memory processing, however the underlying transcriptional differences are unknown. Here, we used RNA sequencing (RNA-seq) to profile the nuclear transcriptomes of each MB neuronal cell subtypes. We identified 350 MB class- or subtype-specific genes, including the widely used alpha/beta class marker Fas2 and the alpha'/beta' class marker trio Immunostaining corroborates the RNA-seq measurements at the protein level for several cases. Importantly, our data provide a full accounting of the neurotransmitter receptors, transporters, neurotransmitter biosynthetic enzymes, neuropeptides, and neuropeptide receptors expressed within each of these cell types. This high-quality, cell type-level transcriptome catalog for the Drosophila MB provides a valuable resource for the fly neuroscience community

Nuclear Transcriptomes of the Seven Neuronal Cell Types That Constitute the Drosophila Mushroom Bodies

The insect mushroom body (MB) is a conserved brain structure that plays key roles in a diverse array of behaviors. The Drosophila melanogaster MB is the primary invertebrate model of neural circuits related to memory formation and storage, and its development, morphology, wiring, and function has been extensively studied. MBs consist of intrinsic Kenyon Cells that are divided into three major neuron classes (gamma, alpha'/beta' and alpha/beta) and 7 cell subtypes (gammad, gammam, alpha'/beta'ap, alpha'/beta'm, alpha/betap, alpha/betas and alpha/betac) based on their birth order, morphology, and connectivity. These subtypes play distinct roles in memory processing, however the underlying transcriptional differences are unknown. Here, we used RNA sequencing (RNA-seq) to profile the nuclear transcriptomes of each MB neuronal cell subtypes. We identified 350 MB class- or subtype-specific genes, including the widely used alpha/beta class marker Fas2 and the alpha'/beta' class marker trio Immunostaining corroborates the RNA-seq measurements at the protein level for several cases. Importantly, our data provide a full accounting of the neurotransmitter receptors, transporters, neurotransmitter biosynthetic enzymes, neuropeptides, and neuropeptide receptors expressed within each of these cell types. This high-quality, cell type-level transcriptome catalog for the Drosophila MB provides a valuable resource for the fly neuroscience community