2,519 research outputs found
Duality Cascade in Brane Inflation
We show that brane inflation is very sensitive to tiny sharp features in
extra dimensions, including those in the potential and in the warp factor. This
can show up as observational signatures in the power spectrum and/or
non-Gaussianities of the cosmic microwave background radiation (CMBR). One
general example of such sharp features is a succession of small steps in a
warped throat, caused by Seiberg duality cascade using gauge/gravity duality.
We study the cosmological observational consequences of these steps in brane
inflation. Since the steps come in a series, the prediction of other steps and
their properties can be tested by future data and analysis. It is also possible
that the steps are too close to be resolved in the power spectrum, in which
case they may show up only in the non-Gaussianity of the CMB temperature
fluctuations and/or EE polarization. We study two cases. In the slow-roll
scenario where steps appear in the inflaton potential, the sensitivity of brane
inflation to the height and width of the steps is increased by several orders
of magnitude comparing to that in previously studied large field models. In the
IR DBI scenario where steps appear in the warp factor, we find that the
glitches in the power spectrum caused by these sharp features are generally
small or even unobservable, but associated distinctive non-Gaussianity can be
large. Together with its large negative running of the power spectrum index,
this scenario clearly illustrates how rich and different a brane inflationary
scenario can be when compared to generic slow-roll inflation. Such distinctive
stringy features may provide a powerful probe of superstring theory.Comment: Corrections in Eq.(5.47), Eq (5.48), Eq(5.49) and Fig
Ernst Freund as Precursor of the Rational Study of Corporate Law
Gindis, David, Ernst Freund as Precursor of the Rational Study of Corporate Law (October 27, 2017). Journal of Institutional Economics, Forthcoming. Available at SSRN: https://ssrn.com/abstract=2905547, doi: https://dx.doi.org/10.2139/ssrn.2905547The rise of large business corporations in the late 19th century compelled many American observers to admit that the nature of the corporation had yet to be understood. Published in this context, Ernst Freund's little-known The Legal Nature of Corporations (1897) was an original attempt to come to terms with a new legal and economic reality. But it can also be described, to paraphrase Oliver Wendell Holmes, as the earliest example of the rational study of corporate law. The paper shows that Freund had the intuitions of an institutional economist, and engaged in what today would be called comparative institutional analysis. Remarkably, his argument that the corporate form secures property against insider defection and against outsiders anticipated recent work on entity shielding and capital lock-in, and can be read as an early contribution to what today would be called the theory of the firm.Peer reviewe
The N2K Consortium. II. A Transiting Hot Saturn Around HD 149026 With a Large Dense Core
Doppler measurements from Subaru and Keck have revealed radial velocity
variations in the V=8.15, G0IV star HD 149026 consistent with a Saturn-Mass
planet in a 2.8766 day orbit. Photometric observations at Fairborn Observatory
have detected three complete transit events with depths of 0.003 mag at the
predicted times of conjunction. HD 149026 is now the second brightest star with
a transiting extrasolar planet. The mass of the star, based on interpolation of
stellar evolutionary models, is 1.3 +/- 0.1 solar masses; together with the
Doppler amplitude, K=43.3 m s^-1, we derive a planet mass Msin(i)=0.36 Mjup,
and orbital radius of 0.042 AU. HD 149026 is chromospherically inactive and
metal-rich with spectroscopically derived [Fe/H]=+0.36, Teff=6147 K, log g=4.26
and vsin(i)=6.0 km s^-1. Based on Teff and the stellar luminosity of 2.72 Lsun,
we derive a stellar radius of 1.45 Rsun. Modeling of the three photometric
transits provides an orbital inclination of 85.3 +/- 1.0 degrees and (including
the uncertainty in the stellar radius) a planet radius of 0.725 +/- 0.05 Rjup.
Models for this planet mass and radius suggest the presence of a ~67 Mearth
core composed of elements heavier than hydrogen and helium. This substantial
planet core would be difficult to construct by gravitational instability.Comment: 25 pages, 5 figures, accepted by the Astrophysical Journa
Over half of the far-infrared background light comes from galaxies at z >= 1.2
Submillimetre surveys during the past decade have discovered a population of
luminous, high-redshift, dusty starburst galaxies. In the redshift range 1 <= z
<= 4, these massive submillimetre galaxies go through a phase characterized by
optically obscured star formation at rates several hundred times that in the
local Universe. Half of the starlight from this highly energetic process is
absorbed and thermally re-radiated by clouds of dust at temperatures near 30 K
with spectral energy distributions peaking at 100 microns in the rest frame. At
1 <= z <= 4, the peak is redshifted to wavelengths between 200 and 500 microns.
The cumulative effect of these galaxies is to yield extragalactic optical and
far-infrared backgrounds with approximately equal energy densities. Since the
initial detection of the far-infrared background (FIRB), higher-resolution
experiments have sought to decompose this integrated radiation into the
contributions from individual galaxies. Here we report the results of an
extragalactic survey at 250, 350 and 500 microns. Combining our results at 500
microns with those at 24 microns, we determine that all of the FIRB comes from
individual galaxies, with galaxies at z >= 1.2 accounting for 70 per cent of
it. As expected, at the longest wavelengths the signal is dominated by
ultraluminous galaxies at z > 1.Comment: Accepted to Nature. Maps available at http://blastexperiment.info
Mapping gene associations in human mitochondria using clinical disease phenotypes
Nuclear genes encode most mitochondrial proteins, and their mutations cause diverse and debilitating clinical disorders. To date, 1,200 of these mitochondrial genes have been recorded, while no standardized catalog exists of the associated clinical phenotypes. Such a catalog would be useful to develop methods to analyze human phenotypic data, to determine genotype-phenotype relations among many genes and diseases, and to support the clinical diagnosis of mitochondrial disorders. Here we establish a clinical phenotype catalog of 174 mitochondrial disease genes and study associations of diseases and genes. Phenotypic features such as clinical signs and symptoms were manually annotated from full-text medical articles and classified based on the hierarchical MeSH ontology. This classification of phenotypic features of each gene allowed for the comparison of diseases between different genes. In turn, we were then able to measure the phenotypic associations of disease genes for which we calculated a quantitative value that is based on their shared phenotypic features. The results showed that genes sharing more similar phenotypes have a stronger tendency for functional interactions, proving the usefulness of phenotype similarity values in disease gene network analysis. We then constructed a functional network of mitochondrial genes and discovered a higher connectivity for non-disease than for disease genes, and a tendency of disease genes to interact with each other. Utilizing these differences, we propose 168 candidate genes that resemble the characteristic interaction patterns of mitochondrial disease genes. Through their network associations, the candidates are further prioritized for the study of specific disorders such as optic neuropathies and Parkinson disease. Most mitochondrial disease phenotypes involve several clinical categories including neurologic, metabolic, and gastrointestinal disorders, which might indicate the effects of gene defects within the mitochondrial system. The accompanying knowledgebase (http://www.mitophenome.org/) supports the study of clinical diseases and associated genes
Greater temperature sensitivity of plant phenology at colder sites: implications for convergence across northern latitudes
Warmer temperatures are accelerating the phenology of organisms around the world. Temperature sensitivity of phenology might be greater in colder, higher latitude sites than in warmer regions, in part because small changes in temperature constitute greater relative changes in thermal balance at colder sites. To test this hypothesis, we examined up to 20 years of phenology data for 47 tundra plant species at 18 high-latitude sites along a climatic gradient. Across all species, the timing of leaf emergence and flowering was more sensitive to a given increase in summer temperature at colder than warmer high-latitude locations. A similar pattern was seen over time for the flowering phenology of a widespread species, Cassiope tetragona. These are among the first results highlighting differential phenological responses of plants across a climatic gradient and suggest the possibility of convergence in flowering times and therefore an increase in gene flow across latitudes as the climate warms
System Parameters of the Transiting Extrasolar Planet HD 209458b
We derive improved system parameters for the HD 209458 system using a model
that simultaneously fits both photometric transit and radial velocity
observations. The photometry consists of previous Hubble Space Telescope STIS
and FGS observations, twelve I-band transits observed between 2001-2003 with
the Mt. Laguna Observatory 1m telescope, and six Stromgren b+y transits
observed between 2001-2004 with two of the Automatic Photometric Telescopes at
Fairborn Observatory. The radial velocities were derived from Keck/HIRES
observations. The model properly treats the orbital dynamics of the system, and
thus yields robust and physically self-consistent solutions. Our set of system
parameters agrees with previously published results though with improved
accuracy. For example, applying robust limits on the stellar mass of
0.93-1.20Msun, we find 1.26 < Rplanet < 1.42 Rjup and 0.59 < Mplanet < 0.70
Mjup. We can reduce the uncertainty on these estimates by including a stellar
mass-radius relation constraint, yielding Rplanet = 1.35 +/- 0.07 Rjup and
Mplanet = 0.66 +/- 0.04 Mjup. Our results verify that the planetary radius is
10-20% larger than predicted by planet evolution models, confirming the need
for an additional mechanism to slow the evolutionary contraction of the planet.
A revised ephemeris is derived, T0=2452854.82545 + 3.52474554E (HJD), which now
contains an uncertainty in the period of 0.016s and should facilitate future
searches for planetary satellites and other bodies in the HD 209458 system.Comment: 30 pages, 5 figures. To appear in ApJ, 2005 Oct 2
Varespladib and cardiovascular events in patients with an acute coronary syndrome: the VISTA-16 randomized clinical trial
IMPORTANCE: Secretory phospholipase A2(sPLA2) generates bioactive phospholipid products implicated in atherosclerosis. The sPLA2inhibitor varespladib has favorable effects on lipid and inflammatory markers; however, its effect on cardiovascular outcomes is unknown. OBJECTIVE: To determine the effects of sPLA2inhibition with varespladib on cardiovascular outcomes. DESIGN, SETTING, AND PARTICIPANTS: A double-blind, randomized, multicenter trial at 362 academic and community hospitals in Europe, Australia, New Zealand, India, and North America of 5145 patients randomized within 96 hours of presentation of an acute coronary syndrome (ACS) to either varespladib (n = 2572) or placebo (n = 2573) with enrollment between June 1, 2010, and March 7, 2012 (study termination on March 9, 2012). INTERVENTIONS: Participants were randomized to receive varespladib (500 mg) or placebo daily for 16 weeks, in addition to atorvastatin and other established therapies. MAIN OUTCOMES AND MEASURES: The primary efficacy measurewas a composite of cardiovascular mortality, nonfatal myocardial infarction (MI), nonfatal stroke, or unstable angina with evidence of ischemia requiring hospitalization at 16 weeks. Six-month survival status was also evaluated. RESULTS: At a prespecified interim analysis, including 212 primary end point events, the independent data and safety monitoring board recommended termination of the trial for futility and possible harm. The primary end point occurred in 136 patients (6.1%) treated with varespladib compared with 109 patients (5.1%) treated with placebo (hazard ratio [HR], 1.25; 95%CI, 0.97-1.61; log-rank P = .08). Varespladib was associated with a greater risk of MI (78 [3.4%] vs 47 [2.2%]; HR, 1.66; 95%CI, 1.16-2.39; log-rank P = .005). The composite secondary end point of cardiovascular mortality, MI, and stroke was observed in 107 patients (4.6%) in the varespladib group and 79 patients (3.8%) in the placebo group (HR, 1.36; 95% CI, 1.02-1.82; P = .04). CONCLUSIONS AND RELEVANCE: In patients with recent ACS, varespladib did not reduce the risk of recurrent cardiovascular events and significantly increased the risk of MI. The sPLA2inhibition with varespladib may be harmful and is not a useful strategy to reduce adverse cardiovascular outcomes after ACS. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT01130246. Copyright 2014 American Medical Association. All rights reserved
US SOLAS Science Report
The Surface Ocean – Lower Atmosphere Study (SOLAS) (http://www.solas-int.org/) is an international research initiative focused on understanding the key biogeochemical-physical interactions and feedbacks between the ocean and atmosphere that are critical elements of climate and global biogeochemical cycles. Following the release of the SOLAS Decadal Science Plan (2015-2025) (Brévière et al., 2016), the Ocean-Atmosphere Interaction Committee (OAIC) was formed as a subcommittee of the Ocean Carbon and Biogeochemistry (OCB) Scientific Steering Committee to coordinate US SOLAS efforts and activities, facilitate interactions among atmospheric and ocean scientists, and strengthen US contributions to international SOLAS. In October 2019, with support from OCB, the OAIC convened an open community workshop, Ocean-Atmosphere Interactions: Scoping directions for new research with the goal of fostering new collaborations and identifying knowledge gaps and high-priority science questions to formulate a US SOLAS Science Plan. Based on presentations and discussions at the workshop, the OAIC and workshop participants have developed this US SOLAS Science Plan. The first part of the workshop and this Science Plan were purposefully
designed around the five themes of the SOLAS Decadal Science Plan (2015-2025) (Brévière et al., 2016) to provide a common set of research priorities and ensure a more cohesive US contribution to international SOLAS.This report was developed with federal support of NSF (OCE-1558412) and NASA (NNX17AB17G)
LSST Science Book, Version 2.0
A survey that can cover the sky in optical bands over wide fields to faint
magnitudes with a fast cadence will enable many of the exciting science
opportunities of the next decade. The Large Synoptic Survey Telescope (LSST)
will have an effective aperture of 6.7 meters and an imaging camera with field
of view of 9.6 deg^2, and will be devoted to a ten-year imaging survey over
20,000 deg^2 south of +15 deg. Each pointing will be imaged 2000 times with
fifteen second exposures in six broad bands from 0.35 to 1.1 microns, to a
total point-source depth of r~27.5. The LSST Science Book describes the basic
parameters of the LSST hardware, software, and observing plans. The book
discusses educational and outreach opportunities, then goes on to describe a
broad range of science that LSST will revolutionize: mapping the inner and
outer Solar System, stellar populations in the Milky Way and nearby galaxies,
the structure of the Milky Way disk and halo and other objects in the Local
Volume, transient and variable objects both at low and high redshift, and the
properties of normal and active galaxies at low and high redshift. It then
turns to far-field cosmological topics, exploring properties of supernovae to
z~1, strong and weak lensing, the large-scale distribution of galaxies and
baryon oscillations, and how these different probes may be combined to
constrain cosmological models and the physics of dark energy.Comment: 596 pages. Also available at full resolution at
http://www.lsst.org/lsst/sciboo
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