CFHTLenS: Co-evolution of galaxies and their dark matter haloes

Galaxy-galaxy weak lensing is a direct probe of the mean matter distribution around galaxies. The depth and sky coverage of the CFHT Legacy Survey yield statistically significant galaxy halo mass measurements over a much wider range of stellar masses ($10^{8.75}$ to $10^{11.3} M_{\odot}$) and redshifts ($0.2 < z < 0.8$) than previous weak lensing studies. At redshift $z \sim 0.5$, the stellar-to-halo mass ratio (SHMR) reaches a maximum of $4.0\pm0.2$ percent as a function of halo mass at $\sim 10^{12.25} M_{\odot}$. We find, for the first time from weak lensing alone, evidence for significant evolution in the SHMR: the peak ratio falls as a function of cosmic time from $4.5 \pm 0.3$ percent at $z \sim 0.7$ to $3.4 \pm 0.2$ percent at $z \sim 0.3$, and shifts to lower stellar mass haloes. These evolutionary trends are dominated by red galaxies, and are consistent with a model in which the stellar mass above which star formation is quenched "downsizes" with cosmic time. In contrast, the SHMR of blue, star-forming galaxies is well-fit by a power law that does not evolve with time. This suggests that blue galaxies form stars at a rate that is balanced with their dark matter accretion in such a way that they evolve along the SHMR locus. The redshift dependence of the SHMR can be used to constrain the evolution of the galaxy population over cosmic time.Comment: 18 pages, MNRAS, in pres

CFHTLenS: co-evolution of galaxies and their dark matter haloes

Galaxy-galaxy weak lensing is a direct probe of the mean matter distribution around galaxies. The depth and sky coverage of the Canada-France-Hawaii Telescope Legacy Survey yield statistically significant galaxy halo mass measurements over a much wider range of stellar masses (108.75 to 1011.3 M⊙) and redshifts (0.2<z<0.8) than previous weak lensing studies. At redshift z∼0.5, the stellar-to-halo mass ratio (SHMR) reaches a maximum of 4.0±0.2 per cent as a function of halo mass at ∼1012.25 M⊙. We find, for the first time from weak lensing alone, evidence for significant evolution in the SHMR: the peak ratio falls as a function of cosmic time from 4.5±0.3 per cent at z∼0.7 to 3.4±0.2 per cent at z∼0.3, and shifts to lower stellar mass haloes. These evolutionary trends are dominated by red galaxies, and are consistent with a model in which the stellar mass above which star formation is quenched ‘downsizes' with cosmic time. In contrast, the SHMR of blue, star-forming galaxies is well fitted by a power law that does not evolve with time. This suggests that blue galaxies form stars at a rate that is balanced with their dark matter accretion in such a way that they evolve along the SHMR locus. The redshift dependence of the SHMR can be used to constrain the evolution of the galaxy population over cosmic tim

Identification and Validation Model for Informative Liquid Biopsy-Based microRNA Biomarkers:Insights from Germ Cell Tumor In Vitro, In Vivo and Patient-Derived Data

Liquid biopsy-based biomarkers, such as microRNAs, represent valuable tools for patient management, but often do not make it to integration in the clinic. We aim to explore issues impeding this transition, in the setting of germ cell tumors, for which novel biomarkers are needed. We describe a model for identifying and validating clinically relevant microRNAs for germ cell tumor patients, using both in vitro, in vivo (mouse model) and patient-derived data. Initial wide screening of candidate microRNAs is performed, followed by targeted profiling of potentially relevant biomarkers. We demonstrate the relevance of appropriate (negative) controls, experimental conditions (proliferation), and issues related to sample origin (serum, plasma, cerebral spinal fluid) and pre-analytical variables (hemolysis, contaminants, temperature), all of which could interfere with liquid biopsy-based studies and their conclusions. Finally, we show the value of our identification model in a specific scenario, contradicting the presumed role of miR-375 as marker of teratoma histology in liquid biopsy setting. Our findings indicate other putative microRNAs (miR-885-5p, miR-448 and miR-197-3p) fulfilling this clinical need. The identification model is informative to identify the best candidate microRNAs to pursue in a clinical setting

CFHTLenS: the environmental dependence of galaxy halo masses from weak lensing

We use weak gravitational lensing to analyse the dark matter haloes around satellite galaxies in galaxy groups in the Canada–France–Hawaii Telescope Lensing Survey (CFHTLenS) data set. This data set is derived from the Canada–France–Hawaii Telescope Legacy Survey Wide survey, and encompasses 154 deg^2 of high-quality shape data. Using the photometric redshifts, we divide the sample of lens galaxies with stellar masses in the range 10^(9)–10^(10.5) M_⊙ into those likely to lie in high-density environments (HDE) and those likely to lie in low-density environments (LDE). Through comparison with galaxy catalogues extracted from the Millennium Simulation, we show that the sample of HDE galaxies should primarily (∼61 per cent) consist of satellite galaxies in groups, while the sample of LDE galaxies should consist of mostly (∼87 per cent) non-satellite (field and central) galaxies. Comparing the lensing signals around samples of HDE and LDE galaxies matched in stellar mass, the lensing signal around HDE galaxies clearly shows a positive contribution from their host groups on their lensing signals at radii of ∼500–1000 kpc, the typical separation between satellites and group centres. More importantly, the subhaloes of HDE galaxies are less massive than those around LDE galaxies by a factor of 0.65 ± 0.12, significant at the 2.9σ level. A natural explanation is that the haloes of satellite galaxies are stripped through tidal effects in the group environment. Our results are consistent with a typical tidal truncation radius of ∼40 kpc

A novel haemocytometric COVID-19 prognostic score developed and validated in an observational multicentre European hospital-based study

COVID-19 induces haemocytometric changes. Complete blood count changes, including new cell activation parameters, from 982 confirmed COVID-19 adult patients from 11 European hospitals were retrospectively analysed for distinctive patterns based on age, gender, clinical severity, symptom duration, and hospital days. The observed haemocytometric patterns formed the basis to develop a multi-haemocytometric-parameter prognostic score to predict, during the first three days after presentation, which patients will recover without ventilation or deteriorate within a two-week timeframe, needing intensive care or with fatal outcome. The prognostic score, with ROC curve AUC at baseline of 0.753 (95% CI 0.723-0.781) increasing to 0.875 (95% CI 0.806-0.926) on day 3, was superior to any individual parameter at distinguishing between clinical severity. Findings were confirmed in a validation cohort. Aim is that the score and haemocytometry results are simultaneously provided by analyser software, enabling wide applicability of the score as haemocytometry is commonly requested in COVID-19 patients

CFHTLenS: the relation between galaxy dark matter haloes and baryons from weak gravitational lensing

We present a study of the relation between dark matter halo mass and the baryonic content of their host galaxies, quantified through galaxy luminosity and stellar mass. Our investigation uses 154 deg^2 of Canada–France–Hawaii Telescope Lensing Survey (CFHTLenS) lensing and photometric data, obtained from the CFHT Legacy Survey. To interpret the weak lensing signal around our galaxies, we employ a galaxy–galaxy lensing halo model which allows us to constrain the halo mass and the satellite fraction. Our analysis is limited to lenses at redshifts between 0.2 and 0.4, split into a red and a blue sample. We express the relationship between dark matter halo mass and baryonic observable as a power law with pivot points of 10^(11)h^(−2)_(70)L_⊙ and 2×10^(11)h^(−2)_(70)M_⊙ for luminosity and stellar mass, respectively. For the luminosity–halo mass relation, we find a slope of 1.32 ± 0.06 and a normalization of 1.19^(+0.06)_(−0.07)×10^(13)h^(−1)_(70)M_⊙ for red galaxies, while for blue galaxies the best-fitting slope is 1.09^(+0.20)_(−0.13) and the normalization is 0.18^(+0.04)_(−0.05)×10^(13)h^(−1)_(70)M_⊙. Similarly, we find a best-fitting slope of 1.36^(+0.06)_(−0.07) and a normalization of 1.43^(+0.11)_(−0.08)×10^(13)h^(−1)70M_⊙ for the stellar mass–halo mass relation of red galaxies, while for blue galaxies the corresponding values are 0.98^(+0.08)_(−0.07) and 0.84^(+0.20)_(−0.16)×10^(13)h^(−1)70M_⊙. All numbers convey the 68 per cent confidence limit. For red lenses, the fraction which are satellites inside a larger halo tends to decrease with luminosity and stellar mass, with the sample being nearly all satellites for a stellar mass of 2×10^(9)h^(−2)70M_⊙. The satellite fractions are generally close to zero for blue lenses, irrespective of luminosity or stellar mass. This, together with the shallower relation between halo mass and baryonic tracer, is a direct confirmation from galaxy–galaxy lensing that blue galaxies reside in less clustered environments than red galaxies. We also find that the halo model, while matching the lensing signal around red lenses well, is prone to overpredicting the large-scale signal for faint and less massive blue lenses. This could be a further indication that these galaxies tend to be more isolated than assumed

A novel haemocytometric covid-19 prognostic score developed and validated in an observational multicentre european hospital-based study

COVID-19 induces haemocytometric changes. Complete blood count changes, including new cell activation parameters, from 982 confirmed COVID-19 adult patients from 11 European hospitals were retrospectively analysed for distinctive patterns based on age, gender, clinical severity, symptom duration and hospital days. The observed haemocytometric patterns formed the basis to develop a multi-haemocytometric-parameter prognostic score to predict, during the first three days after presentation, which patients will recover without ventilation or deteriorate within a two-week timeframe, needing intensive care or with fatal outcome. The prognostic score, with ROC curve AUC at baseline of 0.753 (95% CI 0.723-0.781) increasing to 0.875 (95% CI 0.806-0.926) on day 3, was superior to any individual parameter at distinguishing between clinical severity. Findings were confirmed in a validation cohort. Aim is that the score and haemocytometry results are simultaneously provided by analyser software, enabling wide applicability of the score as haemocytometry is commonly requested in COVID-19 patients

The realization of a special cohort unit in the prevention of a general outbreak of SARS CoV-2 in Flemish nursing homes

status: Published onlin

Mimicking proteasomal release of polyglutamine peptides initiates aggregation and toxicity

Several neurodegenerative disorders, including Huntington's disease, are caused by expansion of the polyglutamine (polyQ) tract over 40 glutamines in the disease-related protein. Fragments of these proteins containing the expanded polyQ tract are thought to initiate aggregation and represent the toxic species. Although it is not clear how these toxic fragments are generated, in vitro data suggest that proteasomes are unable to digest polyQ tracts. To examine whether the resulting polyQ peptides could initiate aggregation in living cells, we mimicked proteasomal release of monomeric polyQ peptides. These peptides lack the commonly used starting methionine residue or any additional tag. Only expanded polyQ peptides seem to be peptidase resistant, and their accumulation initiated the aggregation process. As observed in polyQ disorders, these aggregates subsequently sequestered proteasomes, ubiquitin and polyQ proteins, and recruited Hsp70. The generated expanded polyQ peptides were toxic to neuronal cells. Our approach mimics proteasomal release of pure polyQ peptides in living cells, and represents a valuable tool to screen for proteins and compounds that affect aggregation and toxicit