Fluctuation Relations for Diffusion Processes

The paper presents a unified approach to different fluctuation relations for classical nonequilibrium dynamics described by diffusion processes. Such relations compare the statistics of fluctuations of the entropy production or work in the original process to the similar statistics in the time-reversed process. The origin of a variety of fluctuation relations is traced to the use of different time reversals. It is also shown how the application of the presented approach to the tangent process describing the joint evolution of infinitesimally close trajectories of the original process leads to a multiplicative extension of the fluctuation relations.Comment: 38 page

A Natural Language Interface for Data Warehouse Question Answering

International audienceBusiness Intelligence (BI) aims at providing methods and tools that lead to quick decisions from trusted data. Such advanced tools require some technical knowledge on how to formulate the queries. We propose a natural language (NL) interface for a Data Warehouse based Question Answering system. This system allows users to query with questions expressed in natural language. The proposed system is fully automated, resulting low Total Cost of Ownership. We aim at demonstrating the importance of identifying already existing semantics and using Text Mining techniques on the Web to move toward the users's need

Paleotectonics of a complex Miocene half graben formed above a detachment fault: The Diligencia basin, Orocopia Mountains, southern California

The Diligencia basin in the Orocopia Mountains of southeastern California has been one of the primary areas used to test the hypothesis of more than 300 km of dextral slip along the combined San Andreas/San Gabriel fault system. The Orocopia Mountains have also been the focus of research on deposition, deformation, metamorphism, uplift and exposure of the Orocopia Schist, which resulted from fl at-slab subduction during the latest Cretaceous/Paleogene Laramide orogeny. The uppermost Oligocene/Lower Miocene Diligencia Formation consists of more than 1500 m of nonmarine strata, including basalt fl ows and intrusions dated at 24-21 Ma. The base of the Diligencia Formation sits nonconformably on Proterozoic augen gneiss and related units along the southern basin boundary, where low-gradient alluvial fans extended into playa-lacustrine environments to the northeast. The northern basal conglomerate of the Diligencia Formation, which was derived from granitic rocks in the Hayfield Mountains to the north, sits unconformably on the Eocene Maniobra Formation. The northern basal conglomerate is overlain by more than 300 m of mostly red sandstone, conglomerate, mudrock and tuff. The basal conglomerate thins and fines westward; paleocurrent measurements suggest deposition on alluvial fans derived from the northeast, an interpretation consistent with a NW-SE-trending normal fault (present orientation) as the controlling structure of the half graben formed during early Diligencia deposition. This fault is hereby named the Diligencia fault, and is interpreted as a SW-dipping normal fault, antithetic to the Orocopia Mountains detachment and related faults. Deposition of the upper Diligencia Formation was infl uenced by a NE-dipping normal fault, synthetic with, and closer to, the exposed detachment faults. The Diligencia Formation is nonconformable on Mesozoic granitoids in the northwest part of the basin. Palinspastic restoration of the Orocopia Mountain area includes the following phases, each of which corresponds with microplate-capture events along the southern California continental margin: (1) Reversal of 240 km of dextral slip on the San Andreas fault (including the Punchbowl and other fault strands) in order to align the San Francisquito-Fenner-Orocopia Mountains detachment-fault system at 6 Ma. (2) Reversal of N-S shortening and 90° of clockwise rotation of the Diligencia basin and Orocopia Mountains, and 40 km of dextral slip on the San Gabriel fault between 12 and 6 Ma. (3) Reversal of 40° of clockwise rotation of the San Gabriel block (including Soledad basin and Sierra Pelona) and 30 km of dextral slip on the Canton fault between 18 and 12 Ma. These palinspastic restorations result in a coherent set of SW-NE-trending normal faults, basins (including Diligenica basin) and antiformal structures consistent with NW-SE-directed crustal extension from 24 to 18 Ma, likely resulting from the unstable configuration of the Mendocino triple junction

Tumor cell plasticity in Ewing sarcoma, an alternative circulatory system stimulated by hypoxia

A striking feature of Ewing sarcoma is the presence of blood lakes lined by tumor cells. The significance of these structures, if any, is unknown. Here, we report that the extent of blood lakes correlates with poor clinical outcomes, whereas variables of angiogenesis do not. We also show that Ewing sarcoma cells form vessel-like tubes in vitro and express genes associated with vasculogenic mimicry. In tumor models, we show that there is blood flow through the blood lakes, suggesting that these structures in Ewing sarcoma contribute to the circulation. Furthermore, we present evidence that reduced oxygen tension may be instrumental in tube formation by plastic tumor cells. The abundant presence of these vasculogenic structures, in contrast to other tumor types, makes Ewing sarcoma the ideal model system to study these phenomena. The results suggest that optimal tumor treatment may require targeting of these structures in combination with prevention of angiogenesis