The Persisting Burden of Intracerebral Haemorrhage: Can Effective Treatments Be Found?

Colin Josephson, Rustam Al-Shahi Salman, and colleagues discuss the effectiveness of treatments for intracerebral haemorrhage

Surface rupture of multiple crustal faults in the 2016 Mw 7.8 Kaikōura, New Zealand, earthquake

Multiple (>20 >20 ) crustal faults ruptured to the ground surface and seafloor in the 14 November 2016 M w Mw 7.8 Kaikōura earthquake, and many have been documented in detail, providing an opportunity to understand the factors controlling multifault ruptures, including the role of the subduction interface. We present a summary of the surface ruptures, as well as previous knowledge including paleoseismic data, and use these data and a 3D geological model to calculate cumulative geological moment magnitudes (M G w MwG ) and seismic moments for comparison with those from geophysical datasets. The earthquake ruptured faults with a wide range of orientations, sense of movement, slip rates, and recurrence intervals, and crossed a tectonic domain boundary, the Hope fault. The maximum net surface displacement was ∼12  m ∼12  m on the Kekerengu and the Papatea faults, and average displacements for the major faults were 0.7–1.5 m south of the Hope fault, and 5.5–6.4 m to the north. M G w MwG using two different methods are M G w MwG 7.7 +0.3 −0.2 7.7−0.2+0.3 and the seismic moment is 33%–67% of geophysical datasets. However, these are minimum values and a best estimate M G w MwG incorporating probable larger slip at depth, a 20 km seismogenic depth, and likely listric geometry is M G w MwG 7.8±0.2 7.8±0.2 , suggests ≤32% ≤32% of the moment may be attributed to slip on the subduction interface and/or a midcrustal detachment. Likely factors contributing to multifault rupture in the Kaikōura earthquake include (1) the presence of the subduction interface, (2) physical linkages between faults, (3) rupture of geologically immature faults in the south, and (4) inherited geological structure. The estimated recurrence interval for the Kaikōura earthquake is ≥5,000–10,000  yrs ≥5,000–10,000  yrs , and so it is a relatively rare event. Nevertheless, these findings support the need for continued advances in seismic hazard modeling to ensure that they incorporate multifault ruptures that cross tectonic domain boundaries

Timing and amount of southern Cascadia earthquake subsidence over the past 1700 years at northern Humboldt Bay, California, USA

Stratigraphic, lithologic, foraminiferal, and radiocarbon analyses indicate that at least four abrupt mud-over-peat contacts are recorded across three sites (Jacoby Creek, McDaniel Creek, and Mad River Slough) in northern Humboldt Bay, California, USA (∼44.8°N, −124.2°W). The stratigraphy records subsidence during past megathrust earthquakes at the southern Cascadia subduction zone ∼40 km north of the Mendocino Triple Junction. Maximum and minimum radiocarbon ages on plant macrofossils from above and below laterally extensive (>6 km) contacts suggest regional synchroneity of subsidence. The shallowest contact has radiocarbon ages that are consistent with the most recent great earthquake at Cascadia, which occurred at 250 cal yr B.P. (1700 CE). Using Bchron and OxCal software, we model ages for the three older contacts of ca. 875 cal yr B.P., ca. 1120 cal yr B.P., and ca. 1620 cal yr B.P. For each of the four earthquakes, we analyze foraminifera across representative mud-over-peat contacts selected from McDaniel Creek. Changes in fossil foraminiferal assemblages across all four contacts reveal sudden relative sea-level (RSL) rise (land subsidence) with submergence lasting from decades to centuries. To estimate subsidence during each earthquake, we reconstructed RSL rise across the contacts using the fossil foraminiferal assemblages in a Bayesian transfer function. The coseismic subsidence estimates are 0.85 ± 0.46 m for the 1700 CE earthquake, 0.42 ± 0.37 m for the ca. 875 cal yr B.P. earthquake, 0.79 ± 0.47 m for the ca. 1120 cal yr B.P. earthquake, and ≥0.93 m for the ca. 1620 cal yr B.P. earthquake. The subsidence estimate for the ca. 1620 cal yr B.P. earthquake is a minimum because the pre-subsidence paleoenvironment likely was above the upper limit of foraminiferal habitation. The subsidence estimate for the ca. 875 cal yr B.P. earthquake is less than (<50%) the subsidence estimates for other contacts and suggests that subsidence magnitude varied over the past four earthquake cycles in southern Cascadia

Timing and amount of southern Cascadia earthquake subsidence over the past 1700 years at northern Humboldt Bay, California, USA

Stratigraphic, lithologic, foraminiferal, and radiocarbon analyses indicate that at least four abrupt mud-over-peat contacts are recorded across three sites (Jacoby Creek, McDaniel Creek, and Mad River Slough) in northern Humboldt Bay, California, USA (∼44.8°N, −124.2°W). The stratigraphy re- cords subsidence during past megathrust earthquakes at the southern Cascadia sub- duction zone ∼40 km north of the Mendocino Triple Junction. Maximum and minimum radiocarbon ages on plant macrofossils from above and below laterally extensive (>6 km) contacts suggest regional synchroneity of subsidence. The shallowest contact has ra- diocarbon ages that are consistent with the most recent great earthquake at Cascadia, which occurred at 250 cal yr B.P. (1700 CE). Using Bchron and OxCal software, we model ages for the three older contacts of ca. 875 cal yr B.P., ca. 1120 cal yr B.P., and ca. 1620 cal yr B.P. For each of the four earthquakes, we ana- lyze foraminifera across representative mud- over-peat contacts selected from McDaniel Creek. Changes in fossil foraminiferal as- semblages across all four contacts reveal sud- den relative sea-level (RSL) rise (land subsid- ence) with submergence lasting from decades to centuries. To estimate subsidence during each earthquake, we reconstructed RSL rise across the contacts using the fossil foraminif- eral assemblages in a Bayesian transfer func- tion. The coseismic subsidence estimates are 0.85 ± 0.46 m for the 1700 CE earthquake, 0.42 ± 0.37 m for the ca. 875 cal yr B.P. earth- quake, 0.79 ± 0.47 m for the ca. 1120 cal yr B.P. earthquake, and ≥0.93 m for the ca. 1620 cal yr B.P. earthquake. The subsidence esti- mate for the ca. 1620 cal yr B.P. earthquake is a minimum because the pre-subsidence paleoenvironment likely was above the upper limit of foraminiferal habitation. The subsid- ence estimate for the ca. 875 cal yr B.P. earth- quake is less than (<50%) the subsidence es- timates for other contacts and suggests that subsidence magnitude varied over the past four earthquake cycles in southern Cascadia

Timing and amount of southern Cascadia earthquake subsidence over the past 1700 years at northern Humboldt Bay, California, USA

Stratigraphic, lithologic, foraminiferal, and radiocarbon analyses indicate that at least four abrupt mud-over-peat contacts are recorded across three sites (Jacoby Creek, McDaniel Creek, and Mad River Slough) in northern Humboldt Bay, California, USA (∼44.8°N, −124.2°W). The stratigraphy re- cords subsidence during past megathrust earthquakes at the southern Cascadia sub- duction zone ∼40 km north of the Mendocino Triple Junction. Maximum and minimum radiocarbon ages on plant macrofossils from above and below laterally extensive (>6 km) contacts suggest regional synchroneity of subsidence. The shallowest contact has ra- diocarbon ages that are consistent with the most recent great earthquake at Cascadia, which occurred at 250 cal yr B.P. (1700 CE). Using Bchron and OxCal software, we model ages for the three older contacts of ca. 875 cal yr B.P., ca. 1120 cal yr B.P., and ca. 1620 cal yr B.P. For each of the four earthquakes, we ana- lyze foraminifera across representative mud- over-peat contacts selected from McDaniel Creek. Changes in fossil foraminiferal as- semblages across all four contacts reveal sud- den relative sea-level (RSL) rise (land subsid- ence) with submergence lasting from decades to centuries. To estimate subsidence during each earthquake, we reconstructed RSL rise across the contacts using the fossil foraminif- eral assemblages in a Bayesian transfer func- tion. The coseismic subsidence estimates are 0.85 ± 0.46 m for the 1700 CE earthquake, 0.42 ± 0.37 m for the ca. 875 cal yr B.P. earth- quake, 0.79 ± 0.47 m for the ca. 1120 cal yr B.P. earthquake, and ≥0.93 m for the ca. 1620 cal yr B.P. earthquake. The subsidence esti- mate for the ca. 1620 cal yr B.P. earthquake is a minimum because the pre-subsidence paleoenvironment likely was above the upper limit of foraminiferal habitation. The subsid- ence estimate for the ca. 875 cal yr B.P. earth- quake is less than (<50%) the subsidence es- timates for other contacts and suggests that subsidence magnitude varied over the past four earthquake cycles in southern Cascadia

Timing and amount of southern Cascadia earthquake subsidence over the past 1700 years at northern Humboldt Bay, California, USA

Stratigraphic, lithologic, foraminiferal, and radiocarbon analyses indicate that at least four abrupt mud-over-peat contacts are recorded across three sites (Jacoby Creek, McDaniel Creek, and Mad River Slough) in northern Humboldt Bay, California, USA (∼44.8°N, −124.2°W). The stratigraphy re- cords subsidence during past megathrust earthquakes at the southern Cascadia sub- duction zone ∼40 km north of the Mendocino Triple Junction. Maximum and minimum radiocarbon ages on plant macrofossils from above and below laterally extensive (>6 km) contacts suggest regional synchroneity of subsidence. The shallowest contact has ra- diocarbon ages that are consistent with the most recent great earthquake at Cascadia, which occurred at 250 cal yr B.P. (1700 CE). Using Bchron and OxCal software, we model ages for the three older contacts of ca. 875 cal yr B.P., ca. 1120 cal yr B.P., and ca. 1620 cal yr B.P. For each of the four earthquakes, we ana- lyze foraminifera across representative mud- over-peat contacts selected from McDaniel Creek. Changes in fossil foraminiferal as- semblages across all four contacts reveal sud- den relative sea-level (RSL) rise (land subsid- ence) with submergence lasting from decades to centuries. To estimate subsidence during each earthquake, we reconstructed RSL rise across the contacts using the fossil foraminif- eral assemblages in a Bayesian transfer func- tion. The coseismic subsidence estimates are 0.85 ± 0.46 m for the 1700 CE earthquake, 0.42 ± 0.37 m for the ca. 875 cal yr B.P. earth- quake, 0.79 ± 0.47 m for the ca. 1120 cal yr B.P. earthquake, and ≥0.93 m for the ca. 1620 cal yr B.P. earthquake. The subsidence esti- mate for the ca. 1620 cal yr B.P. earthquake is a minimum because the pre-subsidence paleoenvironment likely was above the upper limit of foraminiferal habitation. The subsid- ence estimate for the ca. 875 cal yr B.P. earth- quake is less than (<50%) the subsidence es- timates for other contacts and suggests that subsidence magnitude varied over the past four earthquake cycles in southern Cascadia