2,626 research outputs found
Digital business evolution : lessons from a decade of KTP industry projects
Digital transformation is a daunting process for many business leaders, who sometimes find themselves in unfamiliar territory. This challenge is particularly prominent for resource-stretched and multi-skilled small and medium sized enterprises (SMEs). This paper provides a context for this ongoing discussion, and drivers for transformation
will be discussed together with the challenges business leaders are currently facing. Following this, we argue that a digital business can be viewed as an information system
(IS) with six common subsystems; people, data, hardware, software, process and communication, that must interconnect effectively. Finally HINGE the project planning
approach is introduced and how twelve knowledge transfer partnerships informed this approach. The paper highlights that digital transformation is becoming a necessity and
offers a phased approach that enables business leaders to construct a systematic project plan that enables their enterprise to reach new levels of digital maturity in a holistic and meaningful way.
Keywords: digital transformation, digital innovation, strategic change, SMEs, KTP
Not all subhaloes are created equal: modelling the diversity of subhalo density profiles in TNG50
In this work, we analyse the density profiles of subhaloes with masses Msh ≥ 1.4 × 108 M in the TNG50 simulation, with the aim of including baryonic effects. We evaluate the performance of frequently used models, such as the standard Navarro–Frenk–White (NFW), the Einasto, and a smoothly truncated version of the NFW profile. We find that these models do not perform well for the majority of subhaloes, with the NFW profile giving the worst fit in most cases. This is primarily due to mismatches in the inner and outer logarithmic slopes, which are significantly steeper for a large number of subhaloes in the presence of baryons. To address this issue, we propose new three-parameter models and show that they significantly improve the goodness of fit independently of the subhalo’s specific properties. Our best-performing model is a modified version of the NFW profile with an inner log-slope of −2 and a variable truncation that is sharper and steeper than the slope transition in the standard NFW profile. Additionally, we investigate how both the parameter values of the best density profile model and the average density profiles vary with subhalo mass, Vmax, distance from the host halo centre, baryon content, and infall time, and we also present explicit scaling relations for the mean parameters of the individual profiles. The newly proposed fit and the scaling relations are useful to predict the properties of realistic subhaloes in the mass range 108 M ≤Msh ≤ 1013 M that can be influenced by the presence of baryons
Photounbinding of Calmodulin from a Family of CaM Binding Peptides
Background: Recent studies have shown that fluorescently labeled antibodies can be dissociated from their antigen by illumination with laser light. The mechanism responsible for the photounbinding effect, however, remains elusive. Here, we give important insights into the mechanism of photounbinding and show that the effect is not restricted to antibody/ antigen binding. Methodology/Principal Findings: We present studies of the photounbinding of labeled calmodulin (CaM) from a set of CaM-binding peptides with different affinities to CaM after one- and two-photon excitation. We found that the photounbinding effect becomes stronger with increasing binding affinity. Our observation that photounbinding can be influenced by using free radical scavengers, that it does not occur with either unlabeled protein or non-fluorescent quencher dyes, and that it becomes evident shortly after or with photobleaching suggest that photounbinding and photobleaching are closely linked. Conclusions/Significance: The experimental results exclude surface effects, or heating by laser irradiation as potential causes of photounbinding. Our data suggest that free radicals formed through photobleaching may cause a conformationa
Strain and composition dependence of the orbital polarization in nickelate superlattices
A combined analysis of x-ray absorption and resonant reflectivity data was
used to obtain the orbital polarization profiles of superlattices composed of
four-unit-cell-thick layers of metallic LaNiO3 and layers of insulating RXO3
(R=La, Gd, Dy and X=Al, Ga, Sc), grown on substrates that impose either
compressive or tensile strain. This superlattice geometry allowed us to partly
separate the influence of epitaxial strain from interfacial effects controlled
by the chemical composition of the insulating blocking layers. Our quantitative
analysis reveal orbital polarizations up to 25%. We further show that strain is
the most effective control parameter, whereas the influence of the chemical
composition of the blocking layers is comparatively small.Comment: 9 pages, 8 figure
Evolution of spectral properties along the O(6)-U(5) transition in the interacting boson model. II. Classical trajectories
This article continues our previous study of level dynamics in the
[O(6)-U(5)]O(5) transition of the interacting boson model
[nucl-th/0504016] using the semiclassical theory of spectral fluctuations. We
find classical monodromy, related to a singular bundle of orbits with infinite
period at energy E=0, and bifurcations of numerous periodic orbits for E>0. The
spectrum of allowed ratios of periods associated with beta- and
gamma-vibrations exhibits an abrupt change around zero energy. These findings
explain anomalous bunching of quantum states in the E0 region, which
is responsible for the redistribution of levels between O(6) and U(5)
multiplets.Comment: 11 pages, 7 figures; continuation of nucl-th/050401
Interplay of structure and spin-orbit strength in magnetism of metal-benzene sandwiches: from single molecules to infinite wires
Based on first-principles density functional theory calculations we explore
electronic and magnetic properties of experimentally producible sandwiches and
infinite wires made of repeating benzene molecules and transition-metal atoms
of V, Nb, and Ta. We describe the bonding mechanism in the molecules and in
particular concentrate on the origin of magnetism in these structures. We find
that all the considered systems have sizable magnetic moments and ferromagnetic
spin-ordering, with the single exception of the V3-Bz4 molecule. By including
the spin-orbit coupling into our calculations we determine the easy and hard
axes of the magnetic moment, the strength of the uniaxial magnetic anisotropy
energy (MAE), relevant for the thermal stability of magnetic orientation, and
the change of the electronic structure with respect to the direction of the
magnetic moment, important for spin-transport properties. While for the V-based
compounds the values of the MAE are only of the order of 0.05-0.5 meV per metal
atom, increasing the spin-orbit strength by substituting V with heavier Nb and
Ta allows to achieve an increase in anisotropy values by one to two orders of
magnitude. The rigid stability of magnetism in these compounds together with
the strong ferromagnetic ordering makes them attractive candidates for
spin-polarized transport applications. For a Nb-benzene infinite wire the
occurrence of ballistic anisotropic magnetoresistance is demonstrated.Comment: 23 pages, 8 figure
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