540 research outputs found
The first order convergence law fails for random perfect graphs
We consider first order expressible properties of random perfect graphs. That
is, we pick a graph uniformly at random from all (labelled) perfect
graphs on vertices and consider the probability that it satisfies some
graph property that can be expressed in the first order language of graphs. We
show that there exists such a first order expressible property for which the
probability that satisfies it does not converge as .Comment: 11 pages. Minor corrections since last versio
Electronic Structure and Optical Properties of Silicon Nanocrystals along their Aggregation Stages
The structural control of silicon nanocrystals is an important technological
problem. Typically a distribution of nanocrystal sizes and shapes emerges under
the uncontrolled aggregation of smaller clusters. The aim of this computational
study is to investigate the evolution of the nanocrystal electronic states and
their optical properties throughout their aggregation stages. To realistically
tackle such systems, an atomistic electronic structure tool is required that
can accommodate about tens of thousand nanocrystal and embedding lattice atoms
with very irregular shapes. For this purpose, a computationally-efficient
pseudopotential-based electronic structure tool is developed that can handle
realistic nanostructures based on the expansion of the wavefunction of the
aggregate in terms of bulk Bloch bands of the constituent semiconductors. With
this tool, the evolution of the electronic states as well as the
polarization-dependent absorption spectra correlated with the oscillator
strengths over their aggregation stages are traced. The low-lying aggregate
nanocrystal states develop binding and anti-binding counterparts of the
isolated states. Such information may become instrumental with the maturity of
the controlled aggregation of these nanocrystals.Comment: 5 pages, 7 figure
MaterialVis: Material visualization tool using direct volume and surface rendering techniques
Cataloged from PDF version of article.Visualization of the materials is an indispensable part of their structural analysis. We developed a visualization tool for amorphous as well as crystalline structures, called Material Vis. Unlike the existing tools, Material Vis represents material structures as a volume and a surface manifold, in addition to plain atomic coordinates. Both amorphous and crystalline structures exhibit topological features as well as various defects. Material Vis provides a wide range of functionality to visualize such topological structures and crystal defects interactively. Direct volume rendering techniques are used to visualize the volumetric features of materials, such as crystal defects, which are responsible for the distinct fingerprints of a specific sample. In addition, the tool provides surface visualization to extract hidden topological features within the material. Together with the rich set of parameters and options to control the visualization, Material Vis allows users to visualize various aspects of materials very efficiently as generated by modern analytical techniques such as the Atom Probe Tomography. (C) 2014 Elsevier Inc. All rights reserved
Two-dimensional shear modulus of a Langmuir foam
We deform a two-dimensional (2D) foam, created in a Langmuir monolayer, by
applying a mechanical perturbation, and simultaneously image it by Brewster
angle microscopy. We determine the foam stress tensor (through a determination
of the 2D gas-liquid line tension, 2.35 0.4 pJm) and the
statistical strain tensor, by analyzing the images of the deformed structure.
We deduce the 2D shear modulus of the foam, .
The foam effective rigidity is predicted to be , which agrees with the value obtained in an independent mechanical measurement.Comment: submitted May 12, 2003 ; resubmitted Sept 9, 200
Ordering intermetallic alloys by ion irradiation: a way to tailor magnetic media
Combining He ion irradiation and thermal mobility below 600K, we both trigger
and control the transformation from chemical disorder to order in thin films of
an intermetallic ferromagnet (FePd). Kinetic Monte Carlo simulations show how
the initial directional short range order determines order propagation.
Magnetic ordering perpendicular to the film plane was achieved, promoting the
initially weak magnetic anisotropy to the highest values known for FePd films.
This post-growth treatment should find applications in ultrahigh density
magnetic recording.Comment: 7 pages, 3 Figure
Immunoadsorption of agonistic autoantibodies against α1-adrenergic receptors in patients with mild to moderate dementia
Dementia has been shown to be associated with agonistic autoantibodies. The deleterious action of autoantibodies on the {alpha}1-adrenergic receptor for brain vasculature has been demonstrated in animal studies. In the current study, 169 patients with dementia were screened for the presence of agonistic autoantibodies. 47% of patients suffering from mild to moderate Alzheimer's disease and/or vascular dementia carried these autoantibodies. Eight patients positive for autoantibodies underwent immunoadsorption. Patients treated on four consecutive days were subsequently negative for autoantibodies and displayed stabilization of cognitive and mental condition during 12-18 months' follow-up. In patients treated for 2-3 days, autoantibodies were reduced by only 78%. They suffered a rebound of autoantibodies during follow-up, benefited from immunoadsorption too, but their mental parameters worsened. We provide first data on the clinical relevance of agonistic autoantibodies in dementia and show that immunoadsorption is safe and efficient in removing autoantibodies with overall benefits for patients
New insights into the genetic control of gene expression using a Bayesian multi-tissue approach.
The majority of expression quantitative trait locus (eQTL) studies have been carried out in single tissues or cell types, using methods that ignore information shared across tissues. Although global analysis of RNA expression in multiple tissues is now feasible, few integrated statistical frameworks for joint analysis of gene expression across tissues combined with simultaneous analysis of multiple genetic variants have been developed to date. Here, we propose Sparse Bayesian Regression models for mapping eQTLs within individual tissues and simultaneously across tissues. Testing these on a set of 2,000 genes in four tissues, we demonstrate that our methods are more powerful than traditional approaches in revealing the true complexity of the eQTL landscape at the systems-level. Highlighting the power of our method, we identified a two-eQTL model (cis/trans) for the Hopx gene that was experimentally validated and was not detected by conventional approaches. We showed common genetic regulation of gene expression across four tissues for ∼27% of transcripts, providing >5 fold increase in eQTLs detection when compared with single tissue analyses at 5% FDR level. These findings provide a new opportunity to uncover complex genetic regulatory mechanisms controlling global gene expression while the generality of our modelling approach makes it adaptable to other model systems and humans, with broad application to analysis of multiple intermediate and whole-body phenotypes
HIV-1 Drug Resistance Emergence among Breastfeeding Infants Born to HIV-Infected Mothers during a Single-Arm Trial of Triple-Antiretroviral Prophylaxis for Prevention of Mother-To-Child Transmission: A Secondary Analysis
Analysis of a substudy of the Kisumu breastfeeding trial by Clement Zeh and colleagues reveals the emergence of HIV drug resistance in HIV-positive infants born to HIV-infected mothers treated with antiretroviral drugs
Strongly linked current flow in polycrystalline forms of the new superconductor MgB2
The discovery of superconductivity at 39 K in MgB2[1] raises many issues. One
of the central questions is whether this new superconductor resembles a
high-temperature-cuprate superconductor or a low-temperature metallic
superconductor in terms of its current carrying characteristics in applied
magnetic fields. In spite of the very high transition temperatures of the
cuprate superconductors, their performance in magnetic fields has several
drawbacks[2]. Their large anisotropy restricts high bulk current densities to
much less than the full magnetic field-temperature (H-T) space over which
superconductivity is found. Further, weak coupling across grain boundaries
makes transport current densities in untextured polycrystalline forms low and
strongly magnetic field sensitive[3,4]. These studies of MgB2 address both
issues. In spite of the multi-phase, untextured, nano-scale sub-divided nature
of our samples, supercurrents flow throughout without the strong sensitivity to
weak magnetic fields characteristic of Josephson-coupled grains[3].
Magnetization measurements over nearly all of the superconducting H-T plane
show good temperature scaling of the flux pinning force, suggestive of a
current density determined by flux pinning. At least two length scales are
suggested by the magnetization and magneto optical (MO) analysis but the cause
of this seems to be phase inhomogeneity, porosity, and minority insulating
phase such as MgO rather than by weakly coupled grain boundaries. Our results
suggest that polycrystalline ceramics of this new class of superconductor will
not be compromised by the weak link problems of the high temperature
superconductors, a conclusion with enormous significance for applications if
higher temperature analogs of this compound can be discovered
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