On pancultural self-enhancement: well-adjusted Taiwanese self-enhance on personally valued traits

Taiwanese participants made better-than-average judgments on collectivistic and individualistic traits, evaluated the personal importance of those traits, and completed measures of psychological adjustment (depression, perceived stress, subjective well-being, and satisfaction with life). Replicating findings from other East Asian samples, participants self-enhanced (i.e., regarded the self as superior to peers) more on collectivistic than individualistic attributes and assigned higher personal importance to the former than the latter. Moreover, better adjusted participants manifested a stronger tendency to self-enhance on personally important attributes. These data are consistent with the view that self-enhancement is a universal human motive that is expressed tactically and at odds with the assertion that self-enhancement is a uniquely Western phenomenon. <br/

Gene Variants in the Novel Type 2 Diabetes Loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B Affect Different Aspects of Pancreatic β-Cell Function

OBJECTIVE - Recently, results from a meta-analysis of genome-wide association studies have yielded a number of novel type 2 diabetes loci. However, conflicting results have been published regarding their effects on insulin secretion and insulin sensitivity. In this study we used hyperglycemic clamps with three different stimuli to test associations between these novel loci and various measures of β-cell function. RESEARCH DESIGN AND METHODS - For this study, 336 participants, 180 normal glucose tolerant and 156 impaired glucose tolerant, underwent a 2-h hyperglycemic clamp. In a subset we also assessed the response to glucagon-like peptide (GLP)-1 and arginine during an extended clamp (n = 123). All subjects were genotyped for gene variants in JAZF1, CDC123/CAMK1D, TSPAN8/LGR5, THADA, ADAMTS9, NOTCH2/ADAMS30, DCD, VEGFA, BCL11A, HNF1B, WFS1, and MTNR1B. RESULTS - Gene variants in CDC123/CAMK1D, ADAMTS9, BCL11A, and MTNR1B affected various aspects of the insulin response to glucose (all P < 6.9 × 10-3). The THADA gene variant was associated with lower β-cell response to GLP-1 and arginine (both P < 1.6 × 1

Combined Risk Allele Score of Eight Type 2 Diabetes Genes Is Associated With Reduced First-Phase Glucose-Stimulated Insulin Secretion During Hyperglycemic Clamps

OBJECTIVE - At least 20 type 2 diabetes loci have now been identified, and several of these are associated with altered β-cell function. In this study, we have investigated the combined effects of eight known β-cell loci on insulin secretion stimulated by three different secretagogues during hyperglycemic clamps. RESEARCH DESIGN AND METHODS - A total of 447 subjects originating from four independent studies in the Netherlands and Germany (256 with normal glucose tolerance [NGT]/ 191 with impaired glucose tolerance [IGT]) underwent a hyperglycemic clamp. A subset had an extended clamp with additional glucagon-like peptide (GLP)-1 and arginine (n = 224). We next genotyped single nucleotide polymorphisms in TCF7L2, KCNJ11, CDKAL1, IGF2BP2, HHEX/IDE, CDKN2A/B, SLC30A8, and MTNR1B and calculated a risk allele score by risk allele counting. RESULTS - The risk allele score was associated with lower first-phase glucose-stimulated insulin secretion (GSIS) (P = 7.1 × 1

RELATIVE INITIAL POPULATIONS OF FOIL-EXCITED HELIUIM AND LITHIUM AT ION ENERGIES BETWEEN 70 KEV AND 400 KEV

En extension d'un précédent travail, nous avons étudié comment les populations initiales de He et Li, excités par une feuille, varient avec l'énergie du faisceau. Pour un nombre quantique du moment angulaire donné, les populations varient avec le nombre quantique principal n comme n-x. La valeur de l'exposant est proche de trois et ne dépend pas de manière significative de l'énergie du projectile. Entre He et Li, on n'observe que de très faibles différences. La distribution des populations entre les états avec le même n mais des 1 différents ne suit pas la statistique et dépend beaucoup de l'énergie du projectile.Extending earlier measurements we have investigated the energy dependence of the initial populations of foil-excited Helium and Lithium. For a given anqular momentum quantum number 1 the populations scale with the principal quantum number n as n-x. The exponent is close to three and does not depend significantly on the projectile energy. Only small differences between He and Li are observed. The population distribution among the different 1-states with the same n is not statistical and varies strongly with the projectile energy

Dauerstabilitaetsuntersuchungen an einem Kreislaufmedium fuer industrielle ORC-Anlagen Schlussbericht. Abschlussdatum: 30.06.1986

SIGLETIB: FR 154+a / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Modellvorhaben 'Flaechenhafte Verkehrsberuhigung'. Bd. 4 Buergerbeteiligung

TIB: RN 6741(217) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Olig1 Function Is Required to Repress Dlx1/2 and Interneuron Production in Mammalian Brain

SummaryAbnormal GABAergic interneuron density, and imbalance of excitatory versus inhibitory tone, is thought to result in epilepsy, neurodevelopmental disorders, and psychiatric disease. Recent studies indicate that interneuron cortical density is determined primarily by the size of the precursor pool in the embryonic telencephalon. However, factors essential for regulating interneuron allocation from telencephalic multipotent precursors are poorly understood. Here we report that Olig1 represses production of GABAergic interneurons throughout the mouse brain. Olig1 deletion in mutant mice results in ectopic expression and upregulation of Dlx1/2 genes in the ventral medial ganglionic eminences and adjacent regions of the septum, resulting in an ∼30% increase in adult cortical interneuron numbers. We show that Olig1 directly represses the Dlx1/2 I12b intergenic enhancer and that Dlx1/2 functions genetically downstream of Olig1. These findings establish Olig1 as an essential repressor of Dlx1/2 and interneuron production in developing mammalian brain