Strategies Used in Translation of Scientific Texts to Cope with Lexical Gaps (Case of Biomass Gasification and Pyrolysis Book)

Lexical gap in translation is deeply debated during the history of translation studies. Many theories have been put forward to explain the possible strategies of filling lexical gaps. This descriptive study aims to investigate some of these strategies used in the translation of a special technical book, Biomass Gasification & Pyrolysis (Practical Design and Theory), this book was a suitable option, since it has modern topics, some of which have not been discussed or even existed in the target language (Persian). In this study, seventy new terms which have not been employed in Persian (in that field) were selected and examined, the qualitative and quantitative analysis of the words indicated that loan word, loan translation, loanblend were the most prominent strategies to cope with new lexicons; in addition, it also showed that loan translation had the highest rate of usage (68.5%) among other techniques and in scientific contexts it is widely preferred

Varicella Pneumonia: a Case Report in an Immunocompetent Patient

Background: Varicella  (chicken  pox)  is  a  highly  contagious  disease  caused  by  the  Varicella-Zoster  Virus. Varicella pneumonia is a rare presentation of pneumonia, which is seen in immunocompromised adults.Cases Report: Here we reported a 13-year-old immunocompetent boy who was admitted with fever and acute respiratory symptoms.Conclusion: Varicella pneumonia occurring particularly in immunocompromised patients; however, it should not be misdiagnosed in immunocompetent patients

Digoxin Inhibits Retinoblastoma through Suppressing a Non-canonical TGFβ Signaling Pathway.

Aims: Retinoblastoma is a childhood ocular tumor rapidly developing from the immature cells of the retina due to loss of functional retinoblastoma protein. Digoxin, a cardiac glycoside, has been reported to be effective in inducing apoptosis, cell cycle arrest, and cytotoxic effects on human cancers. In this regard, the present study aims to investigate whether digoxin could suppress retinoblastoma cancer through the regulation of transforming growth factor-β (TGF-β) signaling pathway. Methodology: The effects of digoxin on Y-79 cells, retinoblastoma cancer cell line, were investigated using MTT (3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazoli-umbromide) and BrdU (bromodeoxyuridine) assays to measure cellular cytotoxicity effects and cell apoptosis, respectively. Also, a qPCR assay was employed to analyze the mRNA expression levels of TGFβ signaling pathway including C-MYC, P21, P15, TGFβRI, TGFβRII, and SMAD2, 3, and 4 genes. Results: The results of the cell function assays revealed that digoxin inhibited the cell viability and proliferation of Y-79 cells. In addition, it was found that digoxin significantly suppressed C-MYC expression and enhanced the expression of P21, P15, SMAD2 and SMAD4 genes in a dose-and time-dependent manner. However, the obtained results could not detect any significant effect of digoxin on TGFβRI, TGFβRII and SMAD3 genes. Conclusion: Taken together, the findings of the present study suggest that digoxin could be a potential therapeutic agent in the treatment of retinoblastoma by regulating the cell cycle genes via a non-canonical TGF-β signaling pathway

Influence of extrusion 4D printing parameters on the thermal shape-morphing behaviors of polylactic acid (PLA)

A simple and inactive structure is able to transform into a complex and active one via four-dimensional (4D) printing. Controlling bending deformation, activation time, and temperature is crucial in 4D printing. This study aimed to comprehensively evaluate and analyze the effect of different process parameters on the bending deformation of polylactic acid (PLA) shape-morphing produced by material extrusion additive manufacturing. These parameters included layup, layer thickness, printing speed, nozzle temperature, nozzle diameter, and bed temperature. Since the bending deformation is significantly affected by the specimen wall, this study has focused, for the first time, on the simultaneous influence of process parameters and presence of a wall on the deformation. Furthermore, the study examined the influence of printing parameters on activation time and activation temperature. The results indicated that increasing the pre-strain stored in the parts led to a decrease in activation time and activation temperature. Subsequently, the the Taguchi design of experiment method was used to optimize the most influential parameters on the bending deformation. The difference between the optimal predicted and the experimental deformations was less than 2%. Layer thickness, layup, nozzle temperature, and printing speed were recognized respectively as the most effective parameters for controlling deformation

Fisetin-metformin co-loaded in mesoporous silica nanoparticles (MSNs) inhibited triple negative breast cancer proliferation

Objective(s): Herbal compounds with cytotoxicity have been of great interest in recent years to improve cancer treatment methods. Fisetin is an anti-cancer herbal compound with low solubility in aqueous systems. Metformin is another compound with anti-cancer effects. In this study, the combined effect of fisetin and metformin was investigated using mesoporous silica nanoparticles (MSNs) in breast cancer cell lines. Materials and Methods: After the synthesis of nanoparticles, they were characterized using XRD, TEM, SEM. The DLS test showed a size of 143.4 nm with zeta-potential -39.1 mV. Fisetin and metformin were loaded into nanoparticles and loading was confirmed by FTIR. The toxicity of different concentrations of free drug (metformin, fisetin, fisetin-metformin) and Nanoformulations (metformin, fisetin and nano-fisetin-metformin) was investigated on two breast cancer lines MCF7 and MDA-MB-231. Results: Fisetin-metformin co-loaded in MSNs showed the highest cytotoxicity among all formulations in both cell lines. The inhibition of colony formation and migration rate was effectively observed in the co-treatment of cells with fisetin and metformin loaded in nanoparticles compared to single treatments. The expression of tumor suppressor miR-200b-3p and miR-34a-5p showed that fisetin increased the expression of these tumor suppressors compared to the control. Conclusion: The anti-cancer effect of fisetin-metformin in combination increased the expression of tumor suppressors due to the regulation of a wide range of gene network involving in cancer progress. The obtained results highlight the use of MSN as an effective drug delivery system for simultaneous delivery of herbal cytotoxic compounds in cancer

Investigating of the Psychological Health of Women Heads of Household

Objective: The present research investigates the state of psychological health in women who are heads of household and are under welfare protection by the Welfare Organization in Tehran province. The basic research question was whether or not the level of psychological health and its nine indicators according to SCL-90-R are different in women heads of house hold that are under welfare protection compared to women heads of house hold that are not under welfare protection. Materials & Methods: Subjects were over 180 women who were chosen randomly from four different areas in Greater Tehran. The instruments used in this study were SCL-90-R and a demographic questionnaire. A case-control cross sectional method was employed in the present study. Data were analyzed using single-case t-test, independent t-test, and multi-variant regression and Friedman test. Results: Results show that the mean score for psychological health and its nine indicators in the experimental group were significantly higher than the mean score for normal Iranian population (p=0.0009). This indicates that women who are heads of households in Iran are at a higher risk for psychological disorders. The strongest indicators of psychological disorder in these women were depression and psychosomatic complaints. Furthermore, women who are not under welfare protection are significantly more depressed than women who are under welfare protection (p=0.016). Conclusion: Factors which reliably predict women's psychological health are women's income, the income of family members and their own physical health. These results support previous in the field reiterating the fact special attention should be paid to the economical welfare and standards of living in these women

Barriers of child adoption in infertile couples: Iranian's views

Background: There are many reasons why some couples do not become parents. Some are infertile, some do not want kids, children can be in a social context unacceptable and for others different life goals are more important. Objective: This study was designed to determine barriers of child adoption in infertile couples in Iran. Materials and Methods: This cross-sectional study was carried out at Iran from April 2010 to June 2011. The research program was comprised consecutively in 240 infertile couples. Experts in Guidance and Counseling vetted the instrument and set that it has content validity. Test re-test reliability was conducted by the investigators using a sample of 20 couples who have filled questionnaire. Results: Although 230 (96%) of the respondents heard of child adoption, only 89 (37.3%) of couples knew correct meaning of child adoption. Fifty four women (24%) knew how to adopt a baby while the rest did not; 196 (82%) respondents expressed their unwillingness to adopt a baby. Hoping of childbearing (78%) was the main barrier to adopt a child. Conclusion: The barriers mentioned were cultural practices, stigmatization, financial implications, and technical problems. Most of the infertile Iranian couples prefer to stay even so without children or think about new treatment