618 research outputs found
Contour deformation trick in hybrid NLIE
The hybrid NLIE of AdS_5 x S^5 is applied to a wider class of states. We find
that the Konishi state of the orbifold AdS_5 x (S^5/Z_S) satisfies A_1 NLIE
with the source terms which are derived from contour deformation trick. For
general states, we construct a deformed contour with which the contour
deformation trick yields the correct source terms.Comment: 39 pages, 6 figures, v2: discussion on analyticity constraints
replaced by consistent deformed contou
Hybrid-NLIE for the AdS/CFT spectral problem
Hybrid-NLIE equations, an alternative finite NLIE description for the
spectral problem of the super sigma model of AdS/CFT and its gamma-deformations
are derived by replacing the semi-infinite SU(2) and SU(4) parts of the AdS/CFT
TBA equations by a few appropriately chosen complex NLIE variables, which are
coupled among themselves and to the Y-functions associated to the remaining
central nodes of the TBA diagram. The integral equations are written explicitly
for the ground state of the gamma-deformed system. We linearize these NLIE
equations, analytically calculate the first correction to the asymptotic
solution and find agreement with analogous results coming from the original TBA
formalism. Our equations differ substantially from the recently published
finite FiNLIE formulation of the spectral problem.Comment: 63 pages, 1 figur
Extensive Spectroscopy and Photometry of the Type IIP Supernova 2013ej
We present extensive optical (, , and open CCD) and
near-infrared () photometry for the very nearby Type IIP SN ~2013ej
extending from +1 to +461 days after shock breakout, estimated to be MJD
. Substantial time series ultraviolet and optical spectroscopy
obtained from +8 to +135 days are also presented. Considering well-observed SNe
IIP from the literature, we derive bolometric calibrations from
and unfiltered measurements that potentially reach 2\% precision with a
color-dependent correction. We observe moderately strong Si II
as early as +8 days. The photospheric velocity () is
determined by modeling the spectra in the vicinity of Fe II
whenever observed, and interpolating at photometric epochs based on a
semianalytic method. This gives km s at +50
days. We also observe spectral homogeneity of ultraviolet spectra at +10--12
days for SNe IIP, while variations are evident a week after explosion. Using
the expanding photosphere method, from combined analysis of SN 2013ej and SN
2002ap, we estimate the distance to the host galaxy to be
Mpc, consistent with distance estimates from other methods. Photometric and
spectroscopic analysis during the plateau phase, which we estimated to be
days long, yields an explosion energy of
ergs, a final pre-explosion progenitor mass of ~M and a
radius of ~R. We observe a broken exponential profile beyond
+120 days, with a break point at + days. Measurements beyond this
break time yield a Ni mass of ~M.Comment: 29 pages, 23 figures, 15 tables, Published in The Astrophisical
Journa
TBA, NLO Luscher correction, and double wrapping in twisted AdS/CFT
The ground-state energy of integrably-twisted theories is analyzed in finite
volume. We derive the leading and next-to-leading order (NLO) L\"uscher-type
corrections for large volumes of the vacuum energy for integrable theories with
twisted boundary conditions and twisted S-matrix. We then derive the twisted
thermodynamic Bethe ansatz (TBA) equations to describe exactly the ground
state, from which we obtain an untwisted Y-system. The two approaches are
compared by expanding the TBA equations to NLO, and exact agreement is found.
We give explicit results for the O(4) model and for the three-parameter family
of -deformed (non-supersymmetric) planar AdS/CFT model, where the
ground-state energy can be nontrivial and can acquire finite-size corrections.
The NLO corrections, which correspond to double-wrapping diagrams, are
explicitly evaluated for the latter model at six loops.Comment: 42 pages, 2 figures, v2: references added, v3: minor correction
Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons
Amyotrophic lateral sclerosis (ALS) is the most common adult-onset neuromuscular disorder characterised by selective loss of motor neurons leading to fatal paralysis. Current therapeutic approaches are limited in their effectiveness. Substantial advances in understanding ALS disease mechanisms has come from the identification of pathogenic mutations in dominantly inherited familial ALS (FALS). We previously reported a coding mutation in D-amino acid oxidase (DAOR199W) associated with FALS. DAO metabolises D-serine, an essential co-agonist at the N-Methyl-D-aspartic acid glutamate receptor subtype (NMDAR). Using primary motor neuron cultures or motor neuron cell lines we demonstrated that expression of DAOR199W, promoted the formation of ubiquitinated protein aggregates, activated autophagy and increased apoptosis. The aim of this study was to characterise the effects of DAOR199W in vivo, using transgenic mice overexpressing DAOR199W. Marked abnormal motor features, e.g. kyphosis, were evident in mice expressing DAOR199W, which were associated with a significant loss (19%) of lumbar spinal cord motor neurons, analysed at 14 months. When separated by gender, this effect was greater in females (26%; p< 0.0132). In addition, we crossed the DAOR199W transgenic mouse line with the SOD1G93A mouse model of ALS to determine whether the effects of SOD1G93A were potentiated in the double transgenic line (DAOR199W/SOD1G93A). Although overall survival was not affected, onset of neurological signs was significantly earlier in female double transgenic animals than their female SOD1G93A littermates (125 days vs 131 days, P = 0.0239). In summary, some significant in vivo effects of DAOR199W on motor neuron function (i.e. kyphosis and loss of motor neurons) were detected which were most marked in females and could contribute to the earlier onset of neurological signs in double transgenic females compared to SOD1G93A littermates, highlighting the importance of recognizing gender effects present in animal models of ALS
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