994 research outputs found
Market Linked Innovation Systems : Opportunities for Strengthening Agricultural Development in Ethiopia
This study on Strengthening Market Linked Innovation Systems was produced at the request of the Royal Netherlands Embassy in Ethiopia. It offers a perspective on how innovation processes and capacities could be further developed in support of Ethiopia’s Economic Growth and Transformation Plan (EGTP) and the Agricultural Growth Programme (AGP). More specifically it provides recommendations to the Netherlands Embassy on strategic priorities in supporting development of agricultural sector in Ethiopia
Adenovirus infection and immunity in children after stem cell transplantation.
Department of Pediatrics, LUMC, Lab of ImmunologyStamceltransplantatie en Immunomodulati
Acquired platelet antagonism: off-target antiplatelet effects of malignancy treatment with tyrosine kinase inhibitors
Platelets can contribute to tumor progression and metastasis. Cancer patients are at increased risk of thrombosis, and advanced stages of cancer are associated with thrombocytosis or increased platelet reactivity. Tyrosine kinase inhibitors (TKIs) are widely used as a targeted strategy for cancer treatment, with the aim of prolonging progression-free survival of the patients. Because of their broad kinase target spectrum, most TKIs inevitably have off-target effects. Platelets rely on tyrosine kinase activity for their activation. Frequently observed side effects are lowering of platelet count and inhibition of platelet functions, whether or not accompanied by an increased bleeding risk. In this review, we aim to give insights into: (i) 38 TKIs that are currently used for the treatment of different types of cancer, either on the market or in clinical trials; (ii) how distinct TKIs can inhibit activation mechanisms in platelets; and (iii) the clinical consequences of the antiplatelet effects of TKI treatment. For several TKIs, the knowledge on affinity for their targets does not align with the published effects on platelets and reported bleeding events. This review should raise awareness of the potential antiplatelet effects of several TKIs, which will be enhanced in the presence of antithrombotic drugs
Constraints on the Formation and Evolution of Circumstellar Disks in Rotating Magnetized Cloud Cores
We use magnetic collapse models to place some constraints on the formation
and angular momentum evolution of circumstellar disks which are embedded in
magnetized cloud cores. Previous models have shown that the early evolution of
a magnetized cloud core is governed by ambipolar diffusion and magnetic
braking, and that the core takes the form of a nonequilibrium flattened
envelope which ultimately collapses dynamically to form a protostar. In this
paper, we focus on the inner centrifugally-supported disk, which is formed only
after a central protostar exists, and grows by dynamical accretion from the
flattened envelope. We estimate a centrifugal radius for the collapse of mass
shells within a rotating, magnetized cloud core. The centrifugal radius of the
inner disk is related to its mass through the two important parameters
characterizing the background medium: the background rotation rate \Omb and
the background magnetic field strength \Bref. We also revisit the issue of
how rapidly mass is deposited onto the disk (the mass accretion rate) and use
several recent models to comment upon the likely outcome in magnetized cores.
Our model predicts that a significant centrifugal disk (much larger than a
stellar radius) will be present in the very early (Class 0) stage of
protostellar evolution. Additionally, we derive an upper limit for the disk
radius as it evolves due to internal torques, under the assumption that the
star-disk system conserves its mass and angular momentum even while most of the
mass is transferred to a central star.Comment: 23 pages, 1 figure, aastex, to appear in the Astrophysical Journal
(10 Dec 1998
Nonlocality vs. complementarity: a conservative approach to the information problem
A proposal for resolution of the information paradox is that "nice slice"
states, which have been viewed as providing a sharp argument for information
loss, do not in fact do so as they do not give a fully accurate description of
the quantum state of a black hole. This however leaves an information
*problem*, which is to provide a consistent description of how information
escapes when a black hole evaporates. While a rather extreme form of
nonlocality has been advocated in the form of complementarity, this paper
argues that is not necessary, and more modest nonlocality could solve the
information problem. One possible distinguishing characteristic of scenarios is
the information retention time. The question of whether such nonlocality
implies acausality, and particularly inconsistency, is briefly addressed. The
need for such nonlocality, and its apparent tension with our empirical
observations of local quantum field theory, may be a critical missing piece in
understanding the principles of quantum gravity.Comment: 11 pages of text and figures, + references. v2 minor text. v3 small
revisions to match final journal versio
At least someone thinks I’m doing well”: A real-world evaluation of the quit-smoking app StopCoach for lower socio-economic status smokers
Исследование свободных колебаний ортотропных цилиндрических оболочек на основе различных моделей
Досліджуються вільні коливання ортотропних циліндричних оболонок при різних граничних умовах на краях в уточненій постановці з застосуванням теорії Міндліна–Тимошенка та на основі тривимірної теорії пружності. Для розрахунку частот використовується чисельно-аналітичний підхід, який базується на застосуванні сплайн-апроксимації, а також методу колокації, дискретної ортогоналізації разом з методом покрокового пошуку. Проведено порівняння частот циліндричних оболонок з різними граничними умовами на торцях, отриманих в рамках різних моделей.A problem of natural vibrations of orthotropic cylindrical shells under various boundary conditions of its end-faces within the framework of the Mindlin–Timoshenko theory and on the basis of 3-D elasticity theory is considered. Using the method of spline-approximation and collocation, the problems are solved by the steady-state numerical method of discrete orthogonalization with incremental search. The comparison of the frequencies of cylindrical shells with different boundary conditions on their ends within various models is performed
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