The attemped murder by Laban the Aramean: an example of intertextual reading in Midrash

This article deals with the question of why Laban the Aramean, a rather harmless character as presented in the biblical text, is generally portrayed in rabbinic literature as a major enemy of Israel. It is argued that the view of Laban as a villain developed as a result of rabbinic hermeneutics, and that the characteristics attributed to him in rabbinic literature were not arbitrarily chosen due to some extra-textual issue or an ideologically motivated wish to provide him with a set of negative characteristics. Rather, they are an outcome of a reading of the biblical text, albeit a reading that is naturally biased and conditioned by a certain set of assumptions. The rabbis were grappling with the biblical text in a process where they filled in gaps that they perceived in the text and explained repetitions and inconsistencies having certain assumptions of how these features were to be understood. It is suggested that a factor which most probably played a significant  role in developing a negative view of Laban was an intertextual reading of Deut 26:5 and Gen 31:23-25 that seems to have given rise to the idea that Laban attempted to kill Jacob when the latter fled from Haran

Jesus-oriented visions of Judaism in antiquity

This article argues that the Pseudo-Clementine Recognitions 1.27–72, the Pseudo-Clementine Homilies, and the Didascalia Apostolorum – third and fourth century-texts, which combine adherence to Jesus with Jewish law observance – would have made sense to Jews in antiquity as Jewish, although non-rabbinic visions of the history and calling of the people of Israel, and that they ought to be considered as part of the history of Judaism. Recent years have witnessed an emerging trend to reread texts previously regarded as ‘Jewish-Christian’ or ‘heretical Christian’ as Jewish texts, and as evidence of diversity within Judaism in the post-70 period. This understanding emerges from the related insights that rabbinic Judaism was not the only, or even the dominant form of Judaism during the early centuries ce, that there was no definitive early split between a well defined Christianity and an equally well defined Judaism, and that Jewish self-identity in antiquity seems to have allowed for adherence to Jesus as an option within Judaism. Abandoning the practice of using rabbinic Judaism as the sole criterion for defining Jewishness in this time period allows us to see the theologies developed by such Jesus-oriented groups with a Jewish self-identity as profoundly Jewish, although non-rabbinic, visions of the history and calling of biblical Israel

Expression of the global regulator SATB1 is an independent factor of poor prognosis in high grade epithelial ovarian cancer

Background: The global gene regulator Special AT-rich sequence-binding protein1 (SATB1) has been reported to reprogramme tumour cells into a more malignant phenotype and associate with poor clinical outcome in several cancer forms. In this study, we investigated the molecular correlates and prognostic impact of SATB1 expression in human epithelial ovarian cancer (EOC). Findings: Immunohistochemical expression of SATB1 was examined in tissue microarrays with tumours from 151 incident EOC cases from two prospective, population-based cohorts. Benign-appearing fallopian tube epithelium from 32 cases was also analyzed. A multiplier of nuclear fraction and staining intensity of SATB1 was calculated. While barely expressed in tubal epithelium, nuclear SATB1 expression was denoted in 35/151 (23.2%) EOC cases. Spearman's Rho test revealed an inverse correlation between SATB1 expression and histological grade (R = -0.22, p = 0.006) and a positive correlation with expression of dachshund 2 protein (R = 0.28, p = 0.001), phosphorylated Chek1 (R = 0.26, p = 0.002) and minichromosome maintenance protein 3 (R = 0.17, p = 0.042). Univariable Cox regression analysis revealed that SATB1 expression, while not prognostic in the full cohort, was associated with a reduced ovarian cancer-specific survival and 5-year overall survival in high grade tumours (n = 105) (HR = 2.14 and HR = 1.96, respectively). This association remained significant in multivariable analysis, adjusted for age and clinical stage (HR = 2.20 and HR = 2.06, respectively). Conclusions: These results demonstrate that SATB1 expression is an independent factor of poor prognosis in high grade EOC and correlates in vivo with cellular processes involved in the maintenance of DNA integrity. The functional basis for these observations merits further investigation

Age-Related Olfactory Decline is Associated with the BDNF Val66met Polymorphism: Evidence from a Population-Based Study

The present study investigates the effect of the brain-derived neurotrophic factor (BDNF) val66met polymorphism on change in olfactory function in a large scale, longitudinal population-based sample (n = 836). The subjects were tested on a 13 item force-choice odor identification test on two test occasions over a 5-year-interval. Sex, education, health-related factors, and semantic ability were controlled for in the statistical analyses. Results showed an interaction effect of age and BDNF val66met on olfactory change, such that the magnitude of olfactory decline in the older age cohort (70–90 years old at baseline) was larger for the val homozygote carriers than for the met carriers. The older met carriers did not display larger age-related decline in olfactory function compared to the younger group. The BDNF val66met polymorphism did not affect the rate of decline in the younger age cohort (45–65 years). The findings are discussed in the light of the proposed roles of BDNF in neural development and maintenance

Repeated lumbar punctures within 3 days may affect CSF biomarker levels

Lumbar puncture (LP) is a common way of collecting cerebrospinal fluid (CSF) both in the clinic and in research. In this extension of a study on the relationship between sleep deprivation and CSF biomarkers for Alzheimer’s disease, we investigated CSF biomarker dynamics in relation to rebound sleep after sleep deprivation. Two LPs were performed within 3 days in 13 healthy volunteers. We noticed an unexpected sharp rise in biomarker concentrations in the second sample and therefore repeated the experiment, but without sleep intervention, in four additional individuals. The findings were similar in these subjects, suggesting an inherent methodological problem with repeated LPs. The result corroborates findings in studies with repeated CSF collection via indwelling lumbar catheters, and needs to be addressed in, for instance, pharmacodynamic studies employing these techniques

Evaluation of Patient Education Materials for the SMMART Clinic

Community health and health literacy go hand in hand. To better understand the extent of this in within their own community, a group of master’s students in the occupational therapy program at St. Catherine University examined the link between usable educational materials and the local community health clinic. Within the St. Paul community, there’s a strong partnership with the St. Mary’s Health clinics, their affiliate clinic St. Mary’s Medical And Rehabilitation Therapy Clinic (SMMART), and the university. The role of both medical clinics is to provide affordable and comprehensive care to underserved communities. A new element to this is the establishment of the Bienestar clinic under the wing of the SMMART clinic. As occupational therapy students, we developed our master project with an emphasis on identifying barriers that exist in primary healthcare settings from the perspective of Latino individuals. When developing our project, we observed the SMMART clinic and conducted a needs assessment by interviewing the interdisciplinary team members, including but not limited to dietitians, physical assistants, physical therapists, and occupational therapists, and their experience working within the clinic. As a result, responses reported expanding resources for Latino clients. We created client education materials utilizing the Patient Education Material Assessments Tools (PEMAT) to promote readability and accessibility for Latino individuals through an online website with embedded toolkits specific to anxiety, depression, and sleep deficits. Many clients could access these toolkits through the Bienestar website to participate intermittently between therapy sessions to cope with their mental health needs

Evaluation of Patient Education Materials for the SMMART Clinic

Community health and health literacy go hand in hand. To better understand the extent of this in within their own community, a group of master’s students in the occupational therapy program at St. Catherine University examined the link between usable educational materials and the local community health clinic. Within the St. Paul community, there’s a strong partnership with the St. Mary’s Health clinics, their affiliate clinic St. Mary’s Medical And Rehabilitation Therapy Clinic (SMMART), and the university. The role of both medical clinics is to provide affordable and comprehensive care to underserved communities. A new element to this is the establishment of the Bienestar clinic under the wing of the SMMART clinic. As occupational therapy students, we developed our master project with an emphasis on identifying barriers that exist in primary healthcare settings from the perspective of Latino individuals. When developing our project, we observed the SMMART clinic and conducted a needs assessment by interviewing the interdisciplinary team members, including but not limited to dietitians, physical assistants, physical therapists, and occupational therapists, and their experience working within the clinic. As a result, responses reported expanding resources for Latino clients. We created client education materials utilizing the Patient Education Material Assessments Tools (PEMAT) to promote readability and accessibility for Latino individuals through an online website with embedded toolkits specific to anxiety, depression, and sleep deficits. Many clients could access these toolkits through the Bienestar website to participate intermittently between therapy sessions to cope with their mental health needs

Sleep apnea related risk of motor vehicle accidents is reduced by continuous positive airway pressure: Swedish traffic accident registry data

Obstructive sleep apnea (OSA) is associated with an increased risk of motor vehicle accidents (MVAs). The rate of MVAs in patients suspected of having OSA was determined and the effect of continuous positive airway pressure (CPAP) was investigated

Sleep apnea related risk of motor vehicle accidents is reduced by continuous positive airway pressure: Swedish traffic accident registry data

Obstructive sleep apnea (OSA) is associated with an increased risk of motor vehicle accidents (MVAs). The rate of MVAs in patients suspected of having OSA was determined and the effect of continuous positive airway pressure (CPAP) was investigated