Multimodal behavioral treatment of migraine: An Internet-administered, randomized, controlled trial

Introduction. Multimodal approaches in behavioral treatment have gained recent interest, with proven efficacy for migraine. The utility of the Internet has been demonstrated for behavioral treatment of headache disorders, but not specifically for migraine. The aim of the study was to develop and evaluate an Internet-based multimodal behavior treatment (MBT) program for migraine and to test hand massage treatment as an adjunct. Methods. Eighty-three adults, 58 women and 25 men, with at least two migraine attacks a month were recruited via advertisements. An MBT program aiming at improvements in life-style and stress coping was developed for this study and, together with a diary, adapted for use over the Internet. Participants were randomized to MBT with and without hand massage and to a control group, and were followed for 11 months. Questionnaires addressing issues of quality of life (PQ23) and depressive symptoms (MADRS-S) were used. Results. A 50%, or greater, reduction in migraine frequency was found in 40% and 42% of participants of the two groups receiving MBT (with and without hand massage, respectively), who statistically were significantly more improved than participants in the control group. No effect of hand massage was detected, and gender did not show any independent contribution to the effect in a multivariate analysis. Conclusions. MBT administered over the Internet appears feasible and effective in the treatment of migraine, but no effect of hand massage was found. For increased knowledge on long-term effects and the modes of action of the present MBT program, further studies are needed

Cancer cell differentiation heterogeneity and aggressive behavior in solid tumors

The differentiation stage of tumors is a central aspect in the histopathological classification of solid malignancies. The differentiation stage is strongly associated with tumor behavior, and generally an immature tumor is more aggressive than the more differentiated counterpart. While this is common knowledge in surgical pathology, the contribution of differentiation-related gene expression and functions to tumor behavior is often overlooked in the experimental, tumor biological setting. The mechanisms by which tumor cell differentiation stages are perturbed or affected are poorly explored but have recently come into focus with the introduction.of the tumor stem cell concept. While developmental biologists view the differentiation as a unidirectional event, pathologists and tumor biologists have introduced the concept of dedifferentiation to explain phenotypic changes occurring in solid tumors. In this review we discuss the impact of the tumor cell differentiation stage as used in surgical pathology. We further discuss knowledge gained from exploring the molecular basis of the differentiation and dedifferentiation processes in neuroblastoma and breast cancer, two tumor forms where the tumor cell differentiation concept is used in the clinical diagnostic work and where the tumor stem cell theory has been applied

Multi-Class Clustering of Cancer Subtypes through SVM Based Ensemble of Pareto-Optimal Solutions for Gene Marker Identification

With the advancement of microarray technology, it is now possible to study the expression profiles of thousands of genes across different experimental conditions or tissue samples simultaneously. Microarray cancer datasets, organized as samples versus genes fashion, are being used for classification of tissue samples into benign and malignant or their subtypes. They are also useful for identifying potential gene markers for each cancer subtype, which helps in successful diagnosis of particular cancer types. In this article, we have presented an unsupervised cancer classification technique based on multiobjective genetic clustering of the tissue samples. In this regard, a real-coded encoding of the cluster centers is used and cluster compactness and separation are simultaneously optimized. The resultant set of near-Pareto-optimal solutions contains a number of non-dominated solutions. A novel approach to combine the clustering information possessed by the non-dominated solutions through Support Vector Machine (SVM) classifier has been proposed. Final clustering is obtained by consensus among the clusterings yielded by different kernel functions. The performance of the proposed multiobjective clustering method has been compared with that of several other microarray clustering algorithms for three publicly available benchmark cancer datasets. Moreover, statistical significance tests have been conducted to establish the statistical superiority of the proposed clustering method. Furthermore, relevant gene markers have been identified using the clustering result produced by the proposed clustering method and demonstrated visually. Biological relationships among the gene markers are also studied based on gene ontology. The results obtained are found to be promising and can possibly have important impact in the area of unsupervised cancer classification as well as gene marker identification for multiple cancer subtypes

Loss of imprinting of IGF2 correlates with hypermethylation of the H19 differentially methylated region in hepatoblastoma

IGF2, a maternally imprinted foetal growth factor gene, is implicated in many childhood tumours including hepatoblastoma (HB); however, the genetic and epigenetic alterations have not comprehensively been studied. We analysed the methylation status of the H19 differentially methylated region (DMR), loss of heterozygosity (LOH) and allelic expression of IGF2 in 54 HB tumours, and found that 12 tumours (22%) with LOH, 9 (17%) with loss of imprinting (LOI) and 33 (61%) with retention of imprinting (ROI). Biallelic and monoallelic IGF2 expressions correlated with hypermethylation and normal methylation of H19 DMR, respectively, in two tumours with LOI and seven tumours with ROI. Quantitative RT–PCR analysis showed minimal expression of H19 mRNA and substantial expression of IGF2 mRNA in tumours with LOH or LOI, and substantial expression of both H19 and IGF2 mRNAs in tumours with ROI. Increased IGF2 expression with predominant embryonic P3 transcript was found in the majority of HBs with ROI and foetal livers. In contrast to the earlier reports, our findings suggest that the disruption of the enhancer competition model reported in Wilms' tumour may also occur in HB. Both frequencies of LOH and LOI seem to be lower in HB than in Wilms' tumour, reflecting the different tissue origins

Electrochemically synthesized polymers in molecular imprinting for chemical sensing

This critical review describes a class of polymers prepared by electrochemical polymerization that employs the concept of molecular imprinting for chemical sensing. The principal focus is on both conducting and nonconducting polymers prepared by electropolymerization of electroactive functional monomers, such as pristine and derivatized pyrrole, aminophenylboronic acid, thiophene, porphyrin, aniline, phenylenediamine, phenol, and thiophenol. A critical evaluation of the literature on electrosynthesized molecularly imprinted polymers (MIPs) applied as recognition elements of chemical sensors is presented. The aim of this review is to highlight recent achievements in analytical applications of these MIPs, including present strategies of determination of different analytes as well as identification and solutions for problems encountered

eHealth cognitieve gedragstherapie voor patiënten met chronische somatische aandoeningen

-based cognitive behavioral therapy for patients with chronic somatic conditions Many patients with chronic somatic conditions regularly experience impairments in physical and psychological functioning in their daily life. A way to support these patients is to offer online programs based on cognitive behavioral therapy (Internet-based cognitive behavioral therapy; ICBT). Although a substantial evidence base already exists regarding the effectiveness of ICBT in treating, for example, depressive symptoms, research on ICBT for chronic somatic conditions is still upcoming. In recent years, a growing number of randomized controlled trials were published that examined the effectiveness of ICBT in various chronic somatic conditions. To systematically and quantitatively evaluate the results of these studies, a metaanalysis was conducted, the results of which are discussed in this article. Results indicated that ICBT is also overall effective for chronic somatic conditions, with small to moderate effect sizes. Larger effects were occasionally found for disease-specific outcomes such as disease symptoms and disease-specific quality of life. A longer treatment duration was found to be marginally related to a larger decrease in depressive symptoms. In addition to the results of the meta-analysis, this article provides an overview of the recent literature regarding several clinically relevant ICBT topics: cost-effectiveness, guided ICBT interventions versus self-help, the role of treatment duration, and optimal design and implementation of eHealth interventions.FSW - Self-regulation models for health behavior and psychopathology - ou

Autonomous navigation and sign detector learning

This paper presents an autonomous robotic system that incorporates novel Computer Vision, Machine Learning and Data Mining algorithms in order to learn to navigate and discover important visual entities. This is achieved within a Learning from Demonstration (LfD) framework, where policies are derived from example state-to-action mappings. For autonomous navigation, a mapping is learnt from holistic image features (GIST) onto control parameters using Random Forest regression. Additionally, visual entities (road signs e.g. STOP sign) that are strongly associated to autonomously discovered modes of action (e.g. stopping behaviour) are discovered through a novel Percept-Action Mining methodology. The resulting sign detector is learnt without any supervision (no image labeling or bounding box annotations are used). The complete system is demonstrated on a fully autonomous robotic platform, featuring a single camera mounted on a standard remote control car. The robot carries a PC laptop, that performs all the processing on board and in real-time. © 2013 IEEE

Lidar Measurements Supporting the Ocular Hazard Distance Calculation Using Atmospheric Attenuation

A series of lidar measurements has been performed at the Vidsel Test Range, Vidsel, situated in the inland of the very northern part of Sweden, as a part of an assessment of reducing the laser hazard distance using atmospheric attenuation within the calculations of nominal ocular hazard distance (NOHD). The question was “How low is the atmospheric attenuation as function of height in this area, using a wavelength of 1064 nm?” The work included building a ground based backscatter lidar, performing a series of measurements and analyzing the results. The measurements were performed during June to November, 2014, with the objective to measure at clear air and good weather situations. The lidar measurements at 1064 nm showed a very low atmospheric attenuation as a function of height to altitudes of at least 10 km at several occasions. The lowest limit of backscatter coefficient possible to measure with this instrument is 0.3·10-7 m-1 sr-1. Assuming a lidar ratio varying between 30 – 100 sr, this was leading to an extinction coefficient of about 0.9 - 3·10-6 m-1. The atmospheric attenuation reduces the laser hazard distance with about 50 – 56 % depending on the lidar ratio. A recommendation is to monitor the atmospheric attenuation at the occasions when the method to the reduced laser hazard distance using atmospheric attenuation is used

Lidar Measurements Supporting the Ocular Hazard Distance Calculation Using Atmospheric Attenuation

A series of lidar measurements has been performed at the Vidsel Test Range, Vidsel, situated in the inland of the very northern part of Sweden, as a part of an assessment of reducing the laser hazard distance using atmospheric attenuation within the calculations of nominal ocular hazard distance (NOHD). The question was “How low is the atmospheric attenuation as function of height in this area, using a wavelength of 1064 nm?” The work included building a ground based backscatter lidar, performing a series of measurements and analyzing the results. The measurements were performed during June to November, 2014, with the objective to measure at clear air and good weather situations. The lidar measurements at 1064 nm showed a very low atmospheric attenuation as a function of height to altitudes of at least 10 km at several occasions. The lowest limit of backscatter coefficient possible to measure with this instrument is 0.3·10-7 m-1 sr-1. Assuming a lidar ratio varying between 30 – 100 sr, this was leading to an extinction coefficient of about 0.9 - 3·10-6 m-1. The atmospheric attenuation reduces the laser hazard distance with about 50 – 56 % depending on the lidar ratio. A recommendation is to monitor the atmospheric attenuation at the occasions when the method to the reduced laser hazard distance using atmospheric attenuation is used

Lidar Measurements Supporting the Ocular Hazard Distance Calculation Using Atmospheric Attenuation

A series of lidar measurements has been performed at the Vidsel Test Range, Vidsel, situated in the inland of the very northern part of Sweden, as a part of an assessment of reducing the laser hazard distance using atmospheric attenuation within the calculations of nominal ocular hazard distance (NOHD). The question was “How low is the atmospheric attenuation as function of height in this area, using a wavelength of 1064 nm?” The work included building a ground based backscatter lidar, performing a series of measurements and analyzing the results. The measurements were performed during June to November, 2014, with the objective to measure at clear air and good weather situations. The lidar measurements at 1064 nm showed a very low atmospheric attenuation as a function of height to altitudes of at least 10 km at several occasions. The lowest limit of backscatter coefficient possible to measure with this instrument is 0.3·10-7 m-1 sr-1. Assuming a lidar ratio varying between 30 – 100 sr, this was leading to an extinction coefficient of about 0.9 - 3·10-6 m-1. The atmospheric attenuation reduces the laser hazard distance with about 50 – 56 % depending on the lidar ratio. A recommendation is to monitor the atmospheric attenuation at the occasions when the method to the reduced laser hazard distance using atmospheric attenuation is used