55 research outputs found
Partial costs of global climate change adaptation for the supply of raw industrial and municipal water: a methodology and application
Despite growing recognition of the importance of climate change adaptation, few global estimates of the costs involved are available for the water supply sector. We present a methodology for estimating partial global and regional adaptation costs for raw industrial and domestic water supply, for a limited number of adaptation strategies, and apply the method using results of two climate models. In this paper, adaptation costs are defined as those for providing enough raw water to meet future industrial and municipal water demand, based on country-level demand projections to 2050. We first estimate costs for a baseline scenario excluding climate change, and then additional climate change adaptation costs. Increased demand is assumed to be met through a combination of increased reservoir yield and alternative backstop measures. Under such controversial measures, we project global adaptation costs of 73 bn p.a.), which supports the notion of mainstreaming climate change adaptation into broader policy aims. The method provides a tool for estimating broad costs at the global and regional scale; such information is of key importance in international negotiations. © 2010 IOP Publishing Ltd
Low-frequency physical variations in the coastal zone of Ubatuba, northern coast of São Paulo State, Brazil
Application of Consensus Scoring and Principal Component Analysis for Virtual Screening against β-Secretase (BACE-1)
BACKGROUND: In order to identify novel chemical classes of β-secretase (BACE-1) inhibitors, an alternative scoring protocol, Principal Component Analysis (PCA), was proposed to summarize most of the information from the original scoring functions and re-rank the results from the virtual screening against BACE-1. METHOD: Given a training set (50 BACE-1 inhibitors and 9950 inactive diverse compounds), three rank-based virtual screening methods, individual scoring, conventional consensus scoring and PCA, were judged by the hit number in the top 1% of the ranked list. The docking poses were generated by Surflex, five scoring functions (Surflex_Score, D_Score, G_Score, ChemScore, and PMF_Score) were used for pose extraction. For each pose group, twelve scoring functions (Surflex_Score, D_Score, G_Score, ChemScore, PMF_Score, LigScore1, LigScore2, PLP1, PLP2, jain, Ludi_1, and Ludi_2) were used for the pose rank. For a test set, 113,228 chemical compounds (Sigma-Aldrich® corporate chemical directory) were docked by Surflex, then ranked by the same three ranking methods motioned above to select the potential active compounds for experimental test. RESULTS: For the training set, the PCA approach yielded consistently superior rankings compared to conventional consensus scoring and single scoring. For the test set, the top 20 compounds according to conventional consensus scoring were experimentally tested, no inhibitor was found. Then, we relied on PCA scoring protocol to test another different top 20 compounds and two low micromolar inhibitors (S450588 and 276065) were emerged through the BACE-1 fluorescence resonance energy transfer (FRET) assay. CONCLUSION: The PCA method extends the conventional consensus scoring in a quantitative statistical manner and would appear to have considerable potential for chemical screening applications
Advances in structure elucidation of small molecules using mass spectrometry
The structural elucidation of small molecules using mass spectrometry plays an important role in modern life sciences and bioanalytical approaches. This review covers different soft and hard ionization techniques and figures of merit for modern mass spectrometers, such as mass resolving power, mass accuracy, isotopic abundance accuracy, accurate mass multiple-stage MS(n) capability, as well as hybrid mass spectrometric and orthogonal chromatographic approaches. The latter part discusses mass spectral data handling strategies, which includes background and noise subtraction, adduct formation and detection, charge state determination, accurate mass measurements, elemental composition determinations, and complex data-dependent setups with ion maps and ion trees. The importance of mass spectral library search algorithms for tandem mass spectra and multiple-stage MS(n) mass spectra as well as mass spectral tree libraries that combine multiple-stage mass spectra are outlined. The successive chapter discusses mass spectral fragmentation pathways, biotransformation reactions and drug metabolism studies, the mass spectral simulation and generation of in silico mass spectra, expert systems for mass spectral interpretation, and the use of computational chemistry to explain gas-phase phenomena. A single chapter discusses data handling for hyphenated approaches including mass spectral deconvolution for clean mass spectra, cheminformatics approaches and structure retention relationships, and retention index predictions for gas and liquid chromatography. The last section reviews the current state of electronic data sharing of mass spectra and discusses the importance of software development for the advancement of structure elucidation of small molecules
Karriereziele von Ausbildungsärzt:innen für Allgemeinmedizin - wie verändern sich Trends im Ausbildungsverlauf?
PLS and MLR analysis of salting-out effect for chloroform, benzene, chlorobenzene and anisole
Lags in hydrologic recovery following an extreme drought: Assessing the roles of climate and catchment characteristics
Benzene, toluene, ethyl benzene and xylenes in ambient air and Pinus sylvestris L. needles: a comparative study between Belgium, Hungary and Latvia.
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Drought Impacts on Australian Vegetation During the Millennium Drought Measured With Multisource Spaceborne Remote Sensing
During the period from 1997 to 2009, Australia experienced a severe and persistent drought known as the millennium drought (MD). Major water shortages were reported across the continent, and there were some field accounts of tree mortality and dieback, but large‐area assessment has been lacking. Given uncertain projections of future drought conditions in South‐East Australia, analysis of the MD presents a valuable opportunity to assess possible impacts of these future trends. In this study, we analyzed the magnitude and sensitivity of vegetation responses to the MD with satellite‐derived information including the fraction of photosynthetically absorbed radiation, photosynthetic vegetation cover, canopy density derived from vegetation optical depth, and aboveground biomass carbon. Results show that the most severe impacts were concentrated in southeastern Australia where all four biophysical variables exhibited the highest absolute declines. Cultivated lands, followed by grasslands, experienced the largest drought impact and also demonstrated the highest sensitivity to drought compared to natural biomes. Shrublands showed the greatest resistance to drought‐induced declines. Forests exhibited the lowest sensitivity in canopy properties but average drought sensitivity for biomass, similar to other natural biomes. More arid settings tended to have higher drought sensitivity for canopy properties but lower sensitivity to biomass loss. Drought‐induced carbon releases were largest in forested ecosystems and in more humid climatic settings. High sensitivity of forest biomass to drought suggests that a large amount of carbon could be vulnerable to release to the atmosphere
Determination of the geographical origin of green coffee by principal component analysis of carbon, nitrogen and boron stable isotope ratios
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